Anti-Gastric Ulcer Activity of the Water Extract from Payawanorn (Pseuderanthemum Palatiferum)

Abstract

Abstract:Objective: To examine the anti-gastric ulcer activity of Payawanorn (Psuderanthemum palatiferum) water extract (PPE) in rats. Material and Methods: Evaluation of anti-gastric ulcer activity of PPE was performed using three induced gastric ulcers models: (1) ethanol/hydrochloric acid (EtOH/HCl), (2) restraint water immersion stress and (3) indomethacin. Ulcer indices were determined by microscopic examination (10X). Pylorus ligation and gastric-wall mucus determination were used to investigate the mechanism of anti-gastric ulcer activity of PPE. Results: Oral administration of PPE (150, 300 and 600 mg/kg) significantly inhibited gastric ulcer formation induced by EtOH/HCl, by water immersion restraint stress, and by indomethacin in rats (p-value<0.05). PPE at 600 mg/kg showed a high percent inhibition of gastric ulcer formation in all models. In the pylorus-ligated model, pretreatment with PPE had no effect on pH, acidity output or the gastric acid secretion rate, demonstrating that PPE lacks an anti-secretory effect. Gastric wall mucus was markedly preserved by pretreatment PPE at 600 mg/kg (18.91±2.57 µg alcian blue/g wet stomach) after ethanol-induced ulcer when compared to that the control group (12.38±1.02 µg alcian blue/ g wet stomach). Conclusion: PPE possesses an anti-gastric ulcer effect related to the preservation of gastric mucus, supporting the traditional use of P. palatiferum to treat gastric ulcers.

Acute and Ninety-day Oral Toxicity of the Water Extract from the Fresh Leaves of Pseuderanthemum palatiferum in Rats

“…As the potential botanical applications to treat chronic diseases of the plant, however, the fresh leaf of P. palatiferum has been used. The water extract from the leaf of P. palatiferum reveals the hypotensive and bradycardic activities (Khonsung et al, 2011), anti-inflammatory and analgesic activities (Inchab et al, 2019), and gastroprotective activity (Inchab et al, 2018). This study aimed to assess acute and ninety-day oral toxicity of the water extract of the fresh leaf of P. palatiferum in rats because some signs and symptoms of toxicity may appear after repeated exposure.…”