Anti-GAD-associated limbic encephalitis: an unusual clinical manifestation from northwest of Ireland

Mansoor, Salman; Murphy, Kevin

doi:10.1186/s41983-020-0160-1

Cited by 4 publications

(3 citation statements)

References 9 publications

(13 reference statements)

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“…Despite the two years follow -up the results were normal. This experience may suggest that anti-Gad might not always be neoplastic in children, but This paper supports that GAD antibodies could play a pathogenic role in neurological disease [1,6,7].…”

Section: Discussionmentioning

confidence: 51%

Untitled

2022

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Anti-GAD antibodies have been associated with numerous neurological conditions that have a wide variety of presentations. These conditions include limbic encephalitis, stiff person syndrome, opsoclonus-myoclonus-ataxia syndrome, cerebellar ataxia, and status epilepticus. In this paper, we aimed to present a female patient admitted with complaints of acute weakness and right peripheral facial palsy, pancytopenia, hepatosplenomegaly, and anti-glutamate decarboxylase antibody and report the diversity and clinical features of neurological diseases associated with anti-glutamate decarboxylase antibodies. ConclusionBesides the common primary syndromes, other new clinical and neurological manifestations have been associated with anti-anti-glutamate decarboxylase antibodies.

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Section: Discussionmentioning

confidence: 51%

Untitled

2022

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“…GAD antibodies are most frequently found in GABAergic neurons and pancreatic islet cells, with the associated neurological syndromes, such as stiff-person syndrome, limbic encephalitis, and cerebellar ataxia, thought to arise secondary to the loss of inhibitory neurotransmission from GABA [ 61 ]. A recent review of 58 patients with anti-GAD associated encephalitis showed that the most common manifestations were seizures (97%), impaired memory (59%), cognitive impairment (40%), psychiatric symptoms, mainly related to depression or personality change (28%), and status epilepticus (24%) [ 62 ].…”

Section: Reviewmentioning

confidence: 99%

Autoimmune Limbic Encephalitis: A Review of Clinicoradiological Features and the Challenges of Diagnosis

Ding¹,

Dongas²,

Hu³

et al. 2021

Cureus

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“…• BUT with anti-GAD antibodies -common symptoms are seizures (97%), memory impairment (59%), cognitive impairment (40%), psychiatric symptoms, mainly depression or personality changes (28%), and epileptic (24%) [19]. A characteristic symptom of this disease is Stiff-person syndrome.…”

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confidence: 99%

Autoimmune Limbic Encephalitis – literature review

Pokora,

Poloczek

et al. 2024

J Educ Health Sport

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Autoimmune Limbic Encephalitis is a rare disease occurring with a frequency of approximately 13.7/100,000 people, mainly among middle-aged women. The disease is caused by autoantibodies, either synthesised due to the presence of a tumour or having an idiopathic nature. Depending on the type of autoantibodies detected, the disease is divided into subtypes, which differ in the frequency of specific clinical symptoms (most commonly psychosis, mood changes, memory problems, cognitive impairment and seizures) and can direct to detection of a specific type of cancer. Making a prompt diagnosis and initiating treatment is crucial as it ensures a reduction in clinical symptoms and improves survival rate. Broad immunotherapy is used - intravenous immunoglobulin, corticosteroids, azathioprine, rituximab, cyclophosphamide, anti-epileptic drugs and plasmapheresis. The efficacy is high - 80% of patients recover, and relapses occur in only 10% of cases. If a patient is diagnosed with cancer, effective oncological treatment is necessary to achieve complete remission.

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Anti-GAD-associated limbic encephalitis: an unusual clinical manifestation from northwest of Ireland

Cited by 4 publications

References 9 publications

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Autoimmune Limbic Encephalitis: A Review of Clinicoradiological Features and the Challenges of Diagnosis

Autoimmune Limbic Encephalitis – literature review

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