Anti-fungal, anti-oxidant and phytochemical analysis of Plumbago zeylanica L.

Jain, Paras; Sharma, Hunny; Singh, Pallavi

doi:10.1007/s42535-020-00102-z

Cited by 9 publications

(4 citation statements)

References 5 publications

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“…It exhibits significant inhibitory efficacy at 62.5 g/ml against Alternaria spp. but not against S. rolfsii, according to the research [56] .…”

Section: Antimicrobial Activitymentioning

confidence: 92%

A potential review of its traditional uses, Phytochemistry, pharmacology, and toxicity of Plumbago zeylanica

Chowdhury,

Shuvo,

Mannan

2023

J Pharmacogn Phytochem

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The primary source of efficient traditional medications for the treatment of many ailments is medicinal plants. Several pharmacological actions of herbal medicines have led to their usage throughout the past ten years. The useful medical plant Plumbago zeylanica, often known as Plumbago, "white leadwort," "Ceylon leadwort," "Doctorbush," "Chitrak" in India, is used extensively in Africa and Asia to cure various maladies. It belongs to the plumbaginaceae family. The family plumbaginaceae are divided into the plumbaginoideae and staticoideae subfamilies, which may be distinguished by morphological, chemical, and molecular traits. It is a significant medicinal plant with a variety of pharmacological activities, including anticancer, antibacterial, antioxidant, etc. Because of the plant's therapeutic value, pharmaceutical companies randomly sample the environment and there is a decline in Plumbago zeylanica population, making it an over-exploited plant. Therefore, a different method of mass propagating this plant is required. It is a powerful bioactive substance with a lot of promise for use in traditional medical procedures for the treatment of many different ailments. Although it is a crucial plant in the production of herbal products, finding a different method to allow for the widespread propagation of this plant still requires a great commitment. For the expanding needs of Plumbago zeylanica, by invitro technologies at a large scale for progress and subsequent crushed plants should be tremendously helpful. The purpose of this review is to focus the value of medicinal applications, Phytochemistry, pharmacology, toxicity, and its prospective pharmaceutical action for the creation of novel herbal preparations. It has given researchers the chance to do further study and development in this area.

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“…It exhibits significant inhibitory efficacy at 62.5 g/ml against Alternaria spp. but not against S. rolfsii, according to the research [56] .…”

Section: Antimicrobial Activitymentioning

confidence: 92%

A potential review of its traditional uses, Phytochemistry, pharmacology, and toxicity of Plumbago zeylanica

Chowdhury,

Shuvo,

Mannan

2023

J Pharmacogn Phytochem

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“…Pz comprises a range of essential chemical compounds. The GC-MS analysis of Pz revealed the presence of 40 compounds that could contribute to the medicinal property of the plant 5 . Different parts of the plant possess alkaloids, carbohydrates, triterpenoids, flavonoids, gums, mucilage, protein, fatty acids, saponin, 8,28 plumbagin, plumbagic acid, chitanone, plumbaginol, dihydroflavinol, campesterol, stigmasterol, sitosterol, glucopyranoside, sitosterol, 29 naphthoquinones, glycosides, steroids, tannins, phenolic compounds and coumarins 15,30 .…”

Section: Chemical Constituentmentioning

confidence: 99%

“…Pz is one of the most important medicinal plant, commonly known as Chitraka/Chitramol in Sanskrit, White Leadwort/Ceylon leadwort/Doctorbush in English, Sheetraj Hindi in Urdu, belonging to the family Plumbaginaceae 4,5 . It is widely used in traditional medicine for an antiinflammatory and antimicrobial agent.…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory and Anti-Microbial Potential of Plumbago zeylanica L.: A Review

Aleem¹

2020

J. Drug Delivery Ther.

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Plumbago zeylanica L. (Pz) is one of the most important medicinal plant belonging to the family Plumbaginaceae. It is a perennial shrub, growing throughout India and most places of Sri Lanka. It contains various bioactive compounds like alkaloids, flavonoids, naphthoquinones, glycoside, saponins, steroids, tri-terpenoids, coumarins, phenolic compounds etc. Of all the chemical constituents, plumbagin is the principal active compound. Plumbagin (5-hydroxy-2-methyl-1, 4-naphthoquinone-C11H8O3) is primarily present in roots in higher amounts with only about 1% in the whole plant. The literature reveals that the root and root bark have a wider claim in traditional medicines against various diseases as a memory enhancer, anti-inflammatory, anti-microbial, wound healing, anti-malarial, anti-infertility, anticancer, blood coagulation, and anti-oxidant activities. The present study aims to evaluate the anti-inflammatory and antimicrobial properties of this plant. Keyword: Plumbago zeylanica; Sheetraj; Chitrak; Anti-inflammatory; Antimicrobial; Traditional uses

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“…Plumbago zeylanica L. is an important medicinal shrub commonly known as 'Chitramoolam' in Tamil, and native of South Asia; the species are distributed throughout most of the tropics and subtropics; growing in deciduous woodland, savannas and scrublands from sea level up to 2000 m altitude (Jain et al, 2014). Plumbagin is a natural naphthoquinone compound (5-hydroxy-2methyl-1, 4-naphthoquinone) found in three genera (Plumbago, Plumbagella, Ceratostigma) of the tribe Plumbagineae (Van der Vijver, 1972) and also from the insectivorous genera such as Drosera, Dionaea, and Nepenthes (Widhalm and Rhodes, 2016).…”

Section: Introductionmentioning

confidence: 99%

Effect of sample extraction, preparation methods on HPLC quantification of plumbagin in in vivo and in vitro plant parts of Plumbago zeylanica L.

Muralidharan¹,

Jayanthi²,

Surendran³

et al. 2018

Afr. J. Biotechnol.

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Plumbagin is an important therapeutic compound of Plumbago zeylanica L., the commercial demand of this compound warrants optimizing a suitable method to isolate plumbagin in large scale. The present study was undertaken to obtain the maximum recovery of plumbagin content by employing different extraction methods viz., ultra-assisted extraction (UAE), maceration extraction (ME), soxhlet extraction (SE), serial soxhlet extraction (SSE), and serial maceration extraction (SME) from plant parts of P. zeylanica. Plumbagin content of two different sources such as field grown and hardened in vitro regenerated plants were quantified using reversed-phase high-performance liquid chromatography (RP-HPLC). For in vitro cultures, 6-benzylaminopurine (BAP) and Kinetin (KIN) were used for multiple shoot induction from nodal segments of P. zeylanica. Maximum percentage of shoot induction was obtained on MS medium fortified with BAP (6.66 µM) from nodal segments exposed for 6 weeks. Further multiple shoot proliferation and elongation was achieved in MS medium with a combination of BAP (6.66 µM) and KIN (4.44 µM), with the maximum number of shoots (47.3±0.06) and shoot length (2.0±0.06 cm) per explant after 6 weeks of culture. The optimum root induction was observed on MS medium supplemented with 1.23-µM indole-3 butyric acid (IBA) which produced 10.02±0.2 mean roots with 6.2±0. 8 cm root length. Among the extraction methods, the SME method yielded maximum recovery (99.5%) of plumbagin as compared to others. In vitro leaf extract yielded high content of plumbagin (152.02 mg/g-1 DW) as compared to other plant parts (root 115.41 mg/g-1 dry weight; stem 98.02 mg/g-1 dry weight) whereas in vivo leaf, stem and root samples yielded 96.7, 38.59, and 86.35 mg/g DW of plumbagin, respectively. The present observation suggests that the SME was more efficient for obtaining the maximum recovery of plumbagin and it was confirmed with HPLC quantification. Among the field grown and in vitro regenerated plants, the in vitro culture shows more accumulation of plumbagin and is found suitable for commercial extraction.

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Anti-fungal, anti-oxidant and phytochemical analysis of Plumbago zeylanica L.

Cited by 9 publications

References 5 publications

A potential review of its traditional uses, Phytochemistry, pharmacology, and toxicity of Plumbago zeylanica

A potential review of its traditional uses, Phytochemistry, pharmacology, and toxicity of Plumbago zeylanica

Anti-Inflammatory and Anti-Microbial Potential of Plumbago zeylanica L.: A Review

Effect of sample extraction, preparation methods on HPLC quantification of plumbagin in in vivo and in vitro plant parts of Plumbago zeylanica L.

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