Anti-fouling bioactive surfaces

Yu, Qian; Zhang, Yanxia; Wang, Hongwei; Brash, John L.; Chen, Hong

doi:10.1016/j.actbio.2010.12.021

Cited by 286 publications

(243 citation statements)

References 108 publications

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“…A functional defi nition of a bioactive surface concerns its ability to (a) provide suffi ciently high and well-controlled binding capacities for biomolecules, (b) prevent denaturation of the immobilized biomolecules, and (c) be based on convenient and effi cient techniques for immobilization, ideally reversible to allow regeneration [49]. Furthermore, such surfaces must also prevent non-specifi c interactions, i.e., they must be anti-adhesive (or anti-fouling).…”

Section: Surface Modifi Cation Of Silicone Rubbermentioning

confidence: 99%

Functionalization of Silicone Rubber Surfaces towards Biomedical Applications

Rodrigues

Dourado

2014

Concise Encyclopedia of High Performance Silicones

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Section: Surface Modifi Cation Of Silicone Rubbermentioning

confidence: 99%

Functionalization of Silicone Rubber Surfaces towards Biomedical Applications

Rodrigues

Dourado

2014

Concise Encyclopedia of High Performance Silicones

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“…Typically, the anti-biofouling nature of poly(ethylene glycol) prevents opsonization, which is the primary immune response by macrophages that leads to an increased accumulation of contrast agents in the reticuloendothelial system. [51][52][53] The signal increases in the liver up to 5 hours postinjection ( Figure 5D) indicating a long blood retention time, which could be promising for tumor detection.…”

Section: In Vivo Mri Studiesmentioning

confidence: 99%

Synthesis and in vivo magnetic resonance imaging evaluation of biocompatible branched copolymer nanocontrast agents

Jackson¹,

Chandrasekharan²,

Shi³

et al. 2015

IJN

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Branched copolymer nanoparticles ( D h =20–35 nm) possessing 1,4,7, 10-tetraazacyclododecane- N , N ′, N ″, N ‴-tetraacetic acid macrocycles within their cores have been synthesized and applied as magnetic resonance imaging (MRI) nanosized contrast agents in vivo. These nanoparticles have been generated from novel functional monomers via reversible addition–fragmentation chain transfer polymerization. The process is very robust and synthetically straightforward. Chelation with gadolinium and preliminary in vivo experiments have demonstrated promising characteristics as MRI contrast agents with prolonged blood retention time, good biocompatibility, and an intravascular distribution. The ability of these nanoparticles to perfuse and passively target tumor cells through the enhanced permeability and retention effect is also demonstrated. These novel highly functional nanoparticle platforms have succinimidyl ester-activated benzoate functionalities within their corona, which make them suitable for future peptide conjugation and subsequent active cell-targeted MRI or the conjugation of fluorophores for bimodal imaging. We have also demonstrated that these branched copolymer nanoparticles are able to noncovalently encapsulate hydrophobic guest molecules, which could allow simultaneous bioimaging and drug delivery.

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“…For example, adhesive proteins (fibronectin, vitronectin or collagen) are immobilized onto different wettability surface for improving cells attachment or promoting specific interaction for biosensor/microarray [3][4][5], and bovine serum albumin is immobilized on hydrophobic and hydrophilic surface for blocking of non-pacific proteins [6]. Moreover, thin film coating on the materials can lead to excellent mechanical properties and biocompatibility of biomaterials.…”

Section: Introductionmentioning

confidence: 99%

Wettability Effect of PECVD-SiO_xFilms on Poly(lactic acid) Induced by Oxygen Plasma on Protein Adsorption and Cell Attachment

Sarapirom

Lee

Jin

et al. 2013

J. Phys.: Conf. Ser.

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Abstract. Surface wettability is an important property of biomaterials. Silicon oxide films have a wide range of applications due to a range of the properties such as the mechanical strength and surface wettability. This paper reports effect of the surface wettability of silicon oxide (SiO x ) films on protein adsorption and cell attachment and proliferation. SiO x films were deposited onto poly(lactic acid) (PLA) substrate using plasma enhanced chemical vapor deposition (PECVD). Octamethylcyclotetrasiloxane (OMCTS:Si 4 O 4 C 8 H 24 ) was used as a precursor with O 2 as a carrier gas. After deposition, the films were treated with O 2 -plasma to adapt wettability. It was found that O 2 -plasma enhanced the wettability of the films without changing the film thickness, while made the surface morphology slightly smoother. The polar component increased after O 2 -plasma treatment as observed in the contact angle measurements. The surface energy of the films was calculated by means of the Owens-Wendt method to resolve the contributions of polar and dispersive components. The chemical structure was characterized using attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy. The films were dense with a high Si-network structure. The reduced carbon content (-CH n , Si-CH 3 ) and increased hydrogen content (-OH) of the O 2 -plasma treated SiO x films led to the polar components enhancing the SiO x wettability. Adsorption of bovine serum albumin (BSA) on the films was investigated by using x-ray photoelectron spectroscopy (XPS). More BSA was adsorbed onto the O 2 -plasma treated SiO x films. Attachment and proliferation of MC3T3-E1 mouse pre-osteoblasts and L929 mouse fibroblasts cells on the SiO x films were evaluated via MTT assay. The cells were attached more to the untreated SiO x films but proliferated more on the surface of the O 2 -plasma treated SiO x films depending on the cell types.

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Anti-fouling bioactive surfaces

Cited by 286 publications

References 108 publications

Functionalization of Silicone Rubber Surfaces towards Biomedical Applications

Functionalization of Silicone Rubber Surfaces towards Biomedical Applications

Synthesis and in vivo magnetic resonance imaging evaluation of biocompatible branched copolymer nanocontrast agents

Wettability Effect of PECVD-SiO_xFilms on Poly(lactic acid) Induced by Oxygen Plasma on Protein Adsorption and Cell Attachment

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Anti-fouling bioactive surfaces

Cited by 286 publications

References 108 publications

Functionalization of Silicone Rubber Surfaces towards Biomedical Applications

Functionalization of Silicone Rubber Surfaces towards Biomedical Applications

Synthesis and in vivo magnetic resonance imaging evaluation of biocompatible branched copolymer nanocontrast agents

Wettability Effect of PECVD-SiOxFilms on Poly(lactic acid) Induced by Oxygen Plasma on Protein Adsorption and Cell Attachment

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Wettability Effect of PECVD-SiO_xFilms on Poly(lactic acid) Induced by Oxygen Plasma on Protein Adsorption and Cell Attachment