2021
DOI: 10.3389/fphys.2021.749770
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Anti-flavivirus Properties of Lipid-Lowering Drugs

Abstract: Although Flaviviruses such as dengue (DENV) and zika (ZIKV) virus are important human pathogens, an effective vaccine or antiviral treatment against them is not available. Hence, the search for new strategies to control flavivirus infections is essential. Several studies have shown that the host lipid metabolism could be an antiviral target because cholesterol and other lipids are required during the replicative cycle of different Flaviviridae family members. FDA-approved drugs with hypolipidemic effects could… Show more

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Cited by 26 publications
(37 citation statements)
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References 277 publications
(405 reference statements)
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“…Some FDA-approved cholesterol-lowering drugs have antiviral properties and are safe for use in humans, which reduces the time and requirements for their study in clinical trials (179). In this regard, statins and metformin are promising candidates for the treatment of infections caused by enveloped viruses, such as Dengue virus (DENV), Zika virus (ZIKV), hepatitis C virus (HCV), Japanese encephalitis virus (JEV), influenza A virus (IAV), and recently for the treatment of SARS-CoV-2 (180)(181)(182)(183)(184). These drugs interfere in different metabolic pathways for lipid synthesis by inhibiting critical cholesterol and fatty acid synthesis (185).…”
Section: Targeting Cholesterol-rich Lipid Rafts As Potential Therapeutics In Sars-cov-2 Infectionmentioning
confidence: 99%
See 1 more Smart Citation
“…Some FDA-approved cholesterol-lowering drugs have antiviral properties and are safe for use in humans, which reduces the time and requirements for their study in clinical trials (179). In this regard, statins and metformin are promising candidates for the treatment of infections caused by enveloped viruses, such as Dengue virus (DENV), Zika virus (ZIKV), hepatitis C virus (HCV), Japanese encephalitis virus (JEV), influenza A virus (IAV), and recently for the treatment of SARS-CoV-2 (180)(181)(182)(183)(184). These drugs interfere in different metabolic pathways for lipid synthesis by inhibiting critical cholesterol and fatty acid synthesis (185).…”
Section: Targeting Cholesterol-rich Lipid Rafts As Potential Therapeutics In Sars-cov-2 Infectionmentioning
confidence: 99%
“…It should be noted that their use as antivirals suggests an acute and short-term treatment, reducing the side effects associated with long periods of treatment (209,(211)(212)(213). Preclinical studies are necessary to evaluate its safety during viral infections, as currently metformin is evaluated during ZIKV infections (184,214,215).…”
Section: Targeting Cholesterol-rich Lipid Rafts As Potential Therapeutics In Sars-cov-2 Infectionmentioning
confidence: 99%
“…JEV in one of enveloped RNA viruses which can caused human severe central system infection diseases,the life cycle of this viruses is critically dependent on host lipid biosynthesis [22] ,pivotal biological function of lipid metabolism during JEV infection [23] .From viral binding and entry,infection by these viruses leads to reorganization of cellular membranes and lipid metabolism to support the production of new viral particles [24,25] . Recent work has focused on de ning the involvement of speci c lipid classes in above process in hopes of identifying potential therapeutic targets for the treatment or prevention of disease.…”
Section: Discussionmentioning
confidence: 99%
“…As HBV and HCV often cause chronic hepatitis, research scientists have developed (are developing) strategies to deal with their infections. As discussed previously, lipid and cholesterol metabolism and homeostasis are crucial for hepatitis viral infection; cholesterol/lipid metabolism have been identified as potential antiviral targets [ 90 ]. Indeed, cellular cholesterol has been identified as a critical factor in a variety of viral infections [ 91 , 92 , 93 , 94 , 95 , 96 ].…”
Section: Therapeutic Potential Of Natural Phytochemicals Targeting Ch...mentioning
confidence: 99%