Anti‐fibrillarin antibodies in systemic sclerosis

Tormey, Vincent; Bunn, Christopher; Denton, Christopher P.; Black, Carol M.

doi:10.1093/rheumatology/40.10.1157

Cited by 123 publications

(100 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nucleolar staining has been observed in 8-48% of SSc patient sera (6-10), 12-52% of which have been positive for anti-U3 RNP antibodies (6,9,12,13,27,29). Anti-U3 RNP antibodies have been detected in 5-8% of all SSc patients (7,9,(12)(13)(14).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Anti–U3 RNP autoantibodies in systemic sclerosis

Aggarwal

Lucas

Fertig

et al. 2009

Arthritis & Rheumatism

134

View full text Add to dashboard Cite

Objective. To describe the classification, demographic and clinical features, and survival in anti-U3 RNP autoantibody-positive patients with systemic sclerosis (SSc).Methods. Results. The anti-U3 RNP-positive group had a higher proportion of African American patients (27% versus 5%; P < 0.001) and male patients (29% versus 19%; P ‫؍‬ 0.021), and was younger at the time of first physician diagnosis (mean age 42.8 years versus 47.4 years; P ‫؍‬ 0.001). The 2 groups had similar proportions of patients with diffuse cutaneous involvement (47% and 45% in those with and those without anti-U3 RNP, respectively). However, among patients with diffuse cutaneous involvement, the mean maximum modified Rodnan skin score was significantly lower in the anti-U3 RNP group (22.3 versus 27.9; P < 0.001). Skeletal muscle involvement was more frequent in anti-U3 RNP-positive patients (25% versus 14%; P ‫؍‬ 0.002), as was "intrinsic" pulmonary arterial hypertension (PAH) (31% versus 13%; P < 0.001). The frequency of gastrointestinal involvement, cardiac involvement, pulmonary fibrosis, and "renal crisis" did not differ significantly between the 2 groups. Survival was worse in the anti-U3 RNP-positive group (hazard ratio 1.38 [95% confidence interval 1.05-1.82]). PAH was the most common known cause of death in patients with anti-U3 RNP (30%, versus 10% in the anti-U3 RNP-negative group; P < 0.001).Conclusion. The present findings demonstrate that the frequencies of African American race and male sex are greater among SSc patients with anti-U3 RNP antibody than those without, and the former group is younger at SSc diagnosis. Anti-U3 RNP-positive patients have more frequent skeletal muscle involvement and PAH, the latter being the most common cause of death.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Tormey and colleagues described 42 anti-U3 RNP- (29). In their study, African Americans were disproportionately affected, and diffuse cutaneous involvement was more common than limited skin thickening.…”

Section: Discussionmentioning

confidence: 99%

Anti–U3 RNP autoantibodies in systemic sclerosis

Aggarwal

Lucas

Fertig

et al. 2009

Arthritis & Rheumatism

134

View full text Add to dashboard Cite

show abstract

“…Patients positive for anti-Th/ To autoAbs have a worse prognosis compared to those positive for anti-centromere autoAbs due to the high incidence of associated pulmonary hypertension, interstitial lung fi brosis and renal involvement [6]. Anti-U3-RNP autoAbs are more prevalent in people developing muscular involvement in the course of SSc [7]. The clinical and serological correlations surmise a causal relationship between the specifi c autoimmune response and the disease phenotype.…”

Section: Autoantibodies Immune Cells and Clinical Manifestationsmentioning

confidence: 99%

T Helper Cells in the Immunopathogenesis of Systemic Sclerosis – Current Trends

Kurteva¹,

Kyurkchiev²

2017

Acta Medica Bulgarica

View full text Add to dashboard Cite

show abstract

“…The frequency of AFA differs across ethnic groups, ranging from zero in a large cohort of Italian patients with SSc (7) to 50% in an African American SSc population (8). The higher prevalence of AFA in the sera of African American (AA) patients with SSc has been noted in several studies (9)(10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%