Anti-ferroptosis exosomes engineered for targeting M2 microglia to improve neurological function in ischemic stroke
Yong Wang,
Zhuohang Liu,
Luyu Li
et al.
Abstract:Background
Stroke is a devastating disease affecting populations worldwide and is the primary cause of long-term disability. The inflammatory storm plays a crucial role in the progression of stroke. In the acute phase of ischemic stroke, there is a transient increase in anti-inflammatory M2 microglia followed by a rapid decline. Due to the abundant phospholipid in brain tissue, lipid peroxidation is a notable characteristic of ischemia/reperfusion (I/R), constituting a structural foundation for… Show more
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