Anti-fatigue activities of anthocyanins from Lycium ruthenicum Murry

Abstract

Anthocyanins from Lycium ruthenicum Murry (LRAs) were used to explore the anti-fatigue activities of LRAs at different concentrations in a mouse fatigue model. Eight biochemical indexes were determined in liver tissue, muscle tissue and serum. The results showed that the LRAs used in the experiment mainly contained delphinium, petunidin and malvidin. During 21 days of gavage, there was no significant difference in mouse body weight. The exercise time of the LRA-exposed mice increased. LRAs could increase serum glucose (Glu), liver/muscle glycogen and the activity of superoxide dismutase (SOD) and reduce the vitality of lactate dehydrogenase (LDH), the content of malondialdehyde (MDA), the levels of lactic acid (LD) and serum urea nitrogen (BUN). This study indicated that LRAs can enhance exercise endurance, increase sugar reserves, scavenge free radicals and improve metabolism, thereby increasing anti-fatigue activities.

Research Progress on Active Ingredients and Product Development of Lycium ruthenicum Murray

“…Additionally, anthocyanins undergo reactive discoloration in response to pH variations. Utilizing a straightforward approach, intelligent labels can be affixed to filter substrates to enable the swift, non-destructive testing of meat product freshness within packaging, thereby safeguarding consumer health [76].…”

Advances in the Preparation, Structure and Bioactivity of Polysaccharides from Lycium ruthenicum Murr.: A Review

“…With the advancement of modern pharmacological studies, various biological activities of LRPS have been extensively investigated. Research indicates that LRPS show diverse biological activities, including antioxidant activity [6], anti-fatigue activity [7], anti-tumor activity [8], anti-radiation activity [9], hypoglycemic activity [10], anti-osteoporosis [11], immunomodulatory [12], neuroprotection [13], hepatoprotective activity [14], prebiotic activity [15] and a gastric mucosal protective effect [16].…”

“…The underlying mechanisms include increasing the body's energy substrate reserves, promoting fat utilization for energy, maintaining redox homeostasis, enhancing mitochondrial biogenesis, repairing mitochondrial damage, reducing metabolite accumulation, and inhibiting the accumulation of neurotransmitters [60]. Wang et al [7], through experiments involving weighted swimming, confirmed the anti-fatigue effect of LRPS on normal mice. LRPS extended the swimming time of normal mice, alleviated oxidative stress, lowered post-exercise serum urea and blood lactate levels, increased the reserves of liver glycogen and muscle glycogen, and improved the exercise load capacity of normal mice, making them less prone to fatigue.…”

“…They achieve this by enhancing the insulin signaling pathway through the insulin receptor, activating the PI3K/Akt pathway, and ultimately regulating the ERK/JNK/MAPK pathway [64]. In an animal experiment conducted by Wang et al [7], using a preventive pre-treatment and post-modeling approach and comparing with metformin hydrochloride as a control, although LRPS had a weaker hypoglycemic effect compared to metformin hydrochloride, it significantly lowered blood glucose levels in diabetic mice, increased the activity of serum and hepatic superoxide dismutase (SOD), reduced the content of serum and hepatic malondialdehyde (MDA), and promoted the conversion of glucose into hepatic glycogen.…”

Comparative study on the impact on mouse livers of different amounts of Chinese Baijiu, beer, and wine consumption

“…Of all alcoholic beverages, wine is an interesting and unique product. Wine may be distinguished from the others by the presence of grape-derived phenolic compounds (Deroover et al, 2021;Miele, 2021;Zhang et al, 2022). Somani et al (2015) suggested that grape polyphenols (including anthocyanins, flavonols, favan-3-ols, stilbene, and phenolic acids) could have anti-inflammatory activities that regulate multiple molecular targets and pathways.…”