Anti-exudative effects of opioid receptor agonists in a rat model of carrageenan-induced acute inflammation of the paw

Romero, Asunción; Planas, Eulalia; Poveda, Raquel; Sánchez, Sílvia; Pol, Olga; Puig, Margarita M.

doi:10.1016/j.ejphar.2005.02.004

Cited by 43 publications

(21 citation statements)

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“…In accordance with our results, plasma extravasation induced by antidromic electric stimulation or bradykinin administration was dose dependently inhibited by the administration of selective KOR agonists (Green and Levine, 1992;Barber, 1993). However, no dose-related inhibition of plasma extravasation was induced by U50,488H in a model of carrageenan-induced acute inflammation of the paw (Romero et al, 2005) or in the formalin test (Hong and Abbott, 1995). The administration of the MOR agonist fentanyl also produced a dose-related inhibition .…”

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confidence: 95%

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Antiexudative Effects of Opioids and Expression of κ- and δ- Opioid Receptors during Intestinal Inflammation in Mice: Involvement of Nitric Oxide

Jiménez¹,

Puig²,

Pol³

2005

J Pharmacol Exp Ther

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The study evaluates the effects of -(KOR), ␦-(DOR), and -opioid receptor (MOR) agonists on the inhibition of plasma extravasation during acute and chronic intestinal inflammation in mice. The antiexudative effects of KOR and DOR agonists in animals treated with nitric oxide synthase (NOS) inhibitors and their protein levels in the gut (whole jejunum and mucosa) and spinal cord of mice with chronic intestinal inflammation were also measured. Inflammation was induced by the intragastric administration of one (acute) or two (chronic) doses of croton oil. Plasma extravasation was measured using Evans blue and protein levels by Western blot and immunoprecipitation. Plasma extravasation was significantly increased 2.7 times during chronic inflammation. The potency of the KOR agonist trans-3, 4-dichloro-N-methyl-N-[2-(1-pyrrolydinyl)cyclohexyl]-benzeneazetamine (U50,488H) inhibiting plasma extravasation was enhanced 26.3 times during chronic compared with acute inflammation. [D-Pen 2 ,D-Pen 5 ]-Enkephalin (DPDPE) (a DOR agonist) was also 11.8 times more potent during chronic inflammation, whereas the antiexudative effects of fentanyl (a MOR agonist) were not significantly altered. Receptor-specific antagonists reversed the effects. Protein levels of KOR and DOR in the whole jejunum and mucosa were significantly increased after chronic inflammation. Treatment with NOS inhibitors N -nitro-L-arginine methyl ester or L-N 6 -(1-iminoethyl)-lysine hydrochloride diminished plasma extravasation and inhibited the increased antiexudative effects of U50,488H and DPDPE during chronic intestinal inflammation. The data show that the enhanced antiexudative effects of KOR and DOR agonists could be related to an increased expression of KOR and DOR in the gut and that the release of nitric oxide may play a role augmenting the effects of opioids during chronic inflammation.

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confidence: 95%

“…Opioids reduce plasma extravasation induced by peripheral inflammation by binding to specific opioid receptors located in the central and peripheral nervous systems (Taylor et al, 2000;Romero et al, 2005).…”

Section: Inflammation [D-penmentioning

confidence: 99%

Antiexudative Effects of Opioids and Expression of κ- and δ- Opioid Receptors during Intestinal Inflammation in Mice: Involvement of Nitric Oxide

Jiménez¹,

Puig²,

Pol³

2005

J Pharmacol Exp Ther

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“…Furthermore, opioids can reduce proinflammatory cytokines and adhesion molecules (Belkowski et al, 1995;Wilson et al, 1998;Walker et al, 2000;Philippe et al, 2003), edema and plasma extravasation (Jin et al, 1999;Khalil et al, 1999;Romero et al, 2005;Jiménez et al, 2006;Börzsei et al, 2008), and radiological and histological parameters (Binder et al, 2000(Binder et al, , 2001Walker, 2003). In human tissue sample, opioids have been shown to reduce proinflammatory cytokines, matrix metalloproteinase, and synovial leukocyte counts (Raap et al, 2000;Takeba et al, 2001;Straub et al, 2008).…”

Section: Opioid Effects On Inflammation and Wound Healingmentioning

confidence: 99%

Modulation of Peripheral Sensory Neurons by the Immune System: Implications for Pain Therapy

2011

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“…50 The reversibility of the effects induced by the opioid receptor agonists (edema and extravasation) has been established after the administration of antagonists (i.p.). 51 The work of Lei and Rogers 52 in intact respiratory tissue, for example, suggests that Gene therapy for pancreatitis pain KN Westlund opioid receptors located on both sensory fibers and immune cells are selectively activated by low (neuronal) or high (non-neuronal) doses of m-and d-opioid receptor agonists. It is likely that a similar mechanism is reducing edema and tissue disruption in the HSV-Enk-treated animals where enkephalin is being released directly into the pancreas.…”

Section: Anti-inflammatory Effects and Tissue Protection By Hsv-enk Tmentioning

confidence: 99%

Gene therapy for pancreatitis pain

Westlund

2009

Gene Ther

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Anti-exudative effects of opioid receptor agonists in a rat model of carrageenan-induced acute inflammation of the paw

Cited by 43 publications

References 43 publications

Antiexudative Effects of Opioids and Expression of κ- and δ- Opioid Receptors during Intestinal Inflammation in Mice: Involvement of Nitric Oxide

Antiexudative Effects of Opioids and Expression of κ- and δ- Opioid Receptors during Intestinal Inflammation in Mice: Involvement of Nitric Oxide

Modulation of Peripheral Sensory Neurons by the Immune System: Implications for Pain Therapy

Gene therapy for pancreatitis pain

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