Anti-epiligrin cicatricial pemphigoid in a patient with HIV

Lish, Karen M.; Washenik, Ken; Yancey, Kim B.; Yee, Carole; Rico, M. Joyce

doi:10.1016/s0190-9622(97)80237-x

Cited by 26 publications

(21 citation statements)

References 14 publications

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“…The clinical features of these patients have been indistinguishable from those of patients with other forms of CP. 20,[26][27][28][29][30][31][32][33] All of our patients with AECP had involvement of the oral mucosa, and in all but 1 patient the oropharynx and larynx were also affected. Interestingly, all of our patients were women.…”

Section: Commentmentioning

confidence: 99%

“…Five other cases of AECP have been reported in association with cancer. 27,[29][30][31]34 Whether these findings indicate a causal relation between AECP and malignant neoplasms or rather represent a coincidence requires further study of a larger group of patients during a longer period. The survival rate of our patients with AECP was not favorable.…”

Section: Commentmentioning

confidence: 99%

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Antiepiligrin Cicatricial Pemphigoid

et al. 1999

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Section: Commentmentioning

confidence: 99%

Section: Commentmentioning

confidence: 99%

Antiepiligrin Cicatricial Pemphigoid

et al. 1999

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“…Bisher wurden weltweit nur wenige (n=8) VP-Patienten mit anti-EpiligrinAutoantikörpern in den USA, Südame-rika, Japan und Frankreich in der englisch-sprachigen Literatur beschrieben [8,9,13,14,17] an der epidermalen Seite mit sämtli-chen Immunreaktantien (IgG, IgM, IgA, C3, Fibrin; Grenzzonenphänomen). Daneben fanden sich mehrere anti-IgM-, anti-IgA-und anti-C3-reaktive Kolloidkörper sowie C3 Ablagerungen an den Gefäßen der retikulären Dermis.…”

Section: Untersuchungsbefundunclassified

“…Nach unserem Wissen ist dies der erste in Österreich beschriebene Fall eines VP mit anti-Epiligrin-Autoantikör-pern, welcher klinisch und immunpathologisch den bisher aus den USA, Japan, Frankreich und Südamerika berichteten (acht) Patienten sehr ähnlich ist [8,9,13,14,17].…”

Section: Immunpräzipitation Und Immunoblotunclassified

“…Ein dermales Bindungsmuster charakterisiert aber auch einen kleinen Teil der Patienten mit VP, bei denen die Autoantikörper gegen Epiligrin gerichtet sind [8,9,13,14,17,21]. Epiligrin (auch Laminin-5 oder BM 600 genannt) ist ein aus drei (durch Disulfid-Brücken verbundenen) Untereinheiten (α3, β3, γ2) aufgebautes Adhäsionsmolekül, das einen Hauptbestandteil der in der Lamina lucida lokalisierten Ankerfilamente bildet und eine wichtige Rolle in der Anhaftung basaler Keratinozyten an die Lamina densa der BMZ spielt [6].…”

Section: Immunpräzipitation Und Immunoblotunclassified

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Vernarbendes Pemphigoid mit Autoantikörpern gegen Laminin-5 (Epiligrin) bei einer Patientin mit metastasierendem Endometriumkarzinom

Lenz¹,

Hsu

Yee

et al. 1998

Der Hautarzt

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A 71-year-old female patient presented with erosions of the oral, genital and ocular mucosa, but without skin lesions. One year prior to the onset of lesions, a metastatic adenocarcinoma of the endometrium had been diagnosed. In perilesional skin, direct immunofluorescence showed linear deposits of C3 and IgG along the basement membrane zone. Indirect immunofluorescence demonstrated anti-basement membrane zone antibodies which bound exclusively to the dermal side of 1M NaCl-split skin. In immunoprecipitation studies, the autoantibodies bound a set of proteins characteristic of epiligrin/laminin-5, and they specifically immunoblotted the alpha-subunit of this protein. These results confirmed our presumed diagnosis of anti-epiligrin cicatricial pemphigoid. Combined treatment with methylprednisolone and dapsone resulted in prompt remission, despite progression of her malignancy. So far, only eight patients with anti-epiligrin cicatricial pemphigoid have been reported worldwide. Our patient represents the first case from Austria and is clinically and immunopathologically similar to previously reported cases.

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Antiepiligrin Cicatricial Pemphigoid of the Larynx Successfully Treated With a Combination of Tetracycline and Niacinamide

Sakamoto

Mori

Hashimoto

et al. 2002

Arch Otolaryngol Head Neck Surg

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A case of antiepiligrin cicatricial pemphigoid that primarily involved the larynx and required a tracheostomy was studied. The diagnosis was based on the direct immunofluorescence findings of a biopsy specimen from the glottis, immunofluorescence using normal and 1M sodium chloride-split normal human skin as substrates, and immunoprecipitation. A dramatic clinical improvement was observed after the combined administration of tetracycline hydrochloride and niacinamide. The tracheal stoma could be shut after the narrow segment was cut by means of carbon dioxide laser therapy. The patient showed no respiratory difficulty during the 2-year follow-up period. The combined therapy of tetracycline and niacinamide is thus considered to be an effective treatment for various types of cicatricial pemphigoid.

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Anti-epiligrin cicatricial pemphigoid in a patient with HIV

Cited by 26 publications

References 14 publications

Antiepiligrin Cicatricial Pemphigoid

Antiepiligrin Cicatricial Pemphigoid

Vernarbendes Pemphigoid mit Autoantikörpern gegen Laminin-5 (Epiligrin) bei einer Patientin mit metastasierendem Endometriumkarzinom

Antiepiligrin Cicatricial Pemphigoid of the Larynx Successfully Treated With a Combination of Tetracycline and Niacinamide

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