Anti-epileptogenic and antioxidant effect of Lavandula officinalis aerial part extract against pentylenetetrazol-induced kindling in male mice

Rahmati, Batool; Khalili, Mohsen; Roghani, Mehrdad; Ahghari, Parisa

doi:10.1016/j.jep.2013.04.004

Cited by 40 publications

(30 citation statements)

References 30 publications

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“…The effects of P. daemia were also more marked than those of the antiepileptic drug sodium valproate. The main mechanisms of valproate include an increase in GABAergic activity, reduction in excitatory neurotransmission and modification of monoamines (Xavier et al, 2007; Loscher and Brandt, 2010; Rahmati et al, 2013; Taiwe et al, 2015). These observations suggest that P. daemia could have altered the epileptogenesis process by increasing GABAergic activity and by reducing excitatory neurotransmission.…”

Section: Discussionmentioning

confidence: 99%

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Antiepileptogenic and Neuroprotective Effects of Pergularia daemia on Pilocarpine Model of Epilepsy

et al. 2017

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In this study, we investigated antiepileptogenic and neuroprotective effects of the aqueous extract of Pergularia daemia roots (PDR) using in vivo and in vitro experimental models. In in vivo studies, status epilepticus caused by pilocarpine injection triggers epileptogenesis which evolves during about 1–2 weeks. After 2 h of status epilepticus, mice were treated during the epileptogenesis period for 7 days with sodium valproate and vitamin C (standards which demonstrated to alter epileptogenesis), or Pergularia daemia. The animals were then, 1 week after status epilepticus, challenged with acute pentylenetetrazole (PTZ) administration to test behaviorally the susceptibility to a convulsant agent of animals treated or not with the plan extract. Memory was assessed after PTZ administration in the elevated plus maze and T-maze paradigms at 24 and 48 h. Antioxidant and acetylcholinesterase activities were determined in the hippocampus after sacrifice, in vitro studies were conducted using embryonic rat primary cortical cultures exposed to L-glutamate. Cell survival rate was measured and apoptotic and necrotic cell death determined. The results showed that chronic oral administration of PDR significantly and dose-dependently increased the latency to myoclonic jerks, clonic seizures and generalized tonic–clonic seizures, and the seizure score. In addition, PDR at all doses (from 4.9 to 49 mg/kg) significantly decreased the initial and retention transfer latencies in the elevated plus maze. Interestingly PDR at the same doses significantly increased the time spent and the number of entries in T-maze novel arm. PDR significantly increased the activities of acetylcholinesterase and antioxidant enzymes superoxide dismutase, catalase, and total glutathione and proteins, and decreased malondialdehyde level. Furthermore, PDR increased viability rate of primary cortical neurons after L-glutamate-induced excitotoxicity, in a dose dependent manner. Altogether these results suggest that PDR has antiepileptogenic and neuroprotective effects, which could be mediated by antioxidant and antiapoptotic activities.

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Section: Discussionmentioning

confidence: 99%

“…According to World Health Organization, about three-quarters of the world population rely upon traditional remedies, mainly medicinal plants (Gilani and Rahman, 2005; Rahmati et al, 2013). Among these, the African and Asian tropical/subtropical plant Pergularia daemia (Forsk.)…”

Section: Introductionmentioning

confidence: 99%

Antiepileptogenic and Neuroprotective Effects of Pergularia daemia on Pilocarpine Model of Epilepsy

et al. 2017

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“…was used to induce clonic-tonic convulsions [20–22]. Then, latency to the onset of myoclonus, clonic-tonic, and tonic seizures was recorded; if no convulsion and mortality occurred within 30 min, the animals were considered to be protected from seizures.…”

Section: Methodsmentioning

confidence: 99%

Anticonvulsant and Antioxidant Effects ofTilia americanavar.mexicanaand Flavonoids Constituents in the Pentylenetetrazole-Induced Seizures

Cárdenas-Rodríguez¹,

González-Trujano²,

Aguirre-Hernández

et al. 2014

Oxidative Medicine and Cellular Longevity

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Tilia genus is commonly used around the world for its central nervous system properties; it is prepared as tea and used as tranquilizing, anticonvulsant, and analgesic. In this study, anticonvulsant activity of the Tilia americana var. mexicana inflorescences and leaves was investigated by evaluating organic and aqueous extracts (100, 300, and 600 mg/kg, i.p.) and some flavonoids in the pentylenetetrazole-induced seizures in mice. Moreover, antioxidant effect of these extracts and flavonoids was examined in an in vitro study by using spectrophotometric technique. Significant activity was observed in the methanol extract from inflorescences. An HPLC analysis of the methanol extract from inflorescences and leaves of Tilia allowed demonstrating the respective presence of some partial responsible flavonoid constituents: quercetin (20.09 ± 1.20 μg/mg and 3.39 ± 0.10 μg/mg), rutin (3.52 ± 0.21 μg/mg and 8.94 ± 0.45 μg/mg), and isoquercitrin (1.74 ± 0.01 μg/mg and 1.24 ± 0.13 μg/mg). In addition, significant but different antioxidant properties were obtained among the flavonoids and the extracts investigated. Our results provide evidence of the anticonvulsant activity of Tilia reinforcing its utility for central nervous system diseases whose mechanism of action might involve partial antioxidant effects due to the presence of flavonoids.

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“…T. globiferus shows antioxidant effect in the superoxide dismutase and catalase assay, this corroborates the findings of Adekunle et al (2012) that the leave extract may serve as a good antioxidant due to its high iron chelating capacity. The relationship between antioxidant and anticonvulsant activities has been previously reported (Patrick, 2011;Rahmati et al, 2013). Epilepsy is accompanied by reversible convulsions which induce production of reactive oxygen species (ROS) in the brain, and these free radicals are reported to mediate convulsion development (Rahmati et al, 2013).…”

Section: Discussionmentioning

confidence: 93%

“…The relationship between antioxidant and anticonvulsant activities has been previously reported (Patrick, 2011;Rahmati et al, 2013). Epilepsy is accompanied by reversible convulsions which induce production of reactive oxygen species (ROS) in the brain, and these free radicals are reported to mediate convulsion development (Rahmati et al, 2013). Free radical causes lipid peroxidation at polyunsaturated sites on biological membranes and tissue injury which leads to cell membrane destruction and cell dysfunction (Gupta and Sherma, 1999).…”

Section: Discussionmentioning

confidence: 96%

Antioxidant and antikindling effect of Tapinanthus globiferus growing on Ficus glumosa in pentylenetetrazole induced kindled rats

Abubakar¹,

Yunus²,

Abubakar³

et al. 2018

Afr. J. Biotechnol.

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Tapinanthus globiferus growing on Ficus glumosa is a plant used locally for the treatment of epilepsy.It is found in West Africa on many tree crops. The present study aims to investigate the anti-kindling and antioxidant activity of the aqueous extract of T. globiferus. A total of 40 rats were divided into 4 groups (n=10). Groups 1 to 3 received 100, 200 and 400 mg/kg, respectively, of the extract orally, followed by 35 mg/kg of pentylenetetrazole (PTZ) i.p after an hour. Group 4 (control) was given 35 mg/kg of PTZ and normal saline and also observed for 30 min. This was repeated after every 48 h until all rats in the control group became fully kindled, that is, attained a racine score of 4 or 5 on three consecutive occasions. At the end of the experiment, the brain tissues of all rats were removed, homogenized and analyzed for antioxidant effect using lipid peroxidation, reduced glutathione, catalase, superoxide dismutase and uric acid tests. The extract was observed to significantly (p < 0.001) reduce the development of stage 5 kindling state as compared to the control group. The extract also significantly (p < 0.05) increased the activity of superoxide dismutase in the group treated with 400 mg/kg and also increased the activity of catalase in the 100 mg/kg treated group as compared to the control. The data obtained from this study suggests that the aqueous extract of T. globiferus growing on F. glumosa may possess bioactive compounds with antikindling and antioxidant effect and this may support its traditional use in the management of epilepsy.

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Anti-epileptogenic and antioxidant effect of Lavandula officinalis aerial part extract against pentylenetetrazol-induced kindling in male mice

Cited by 40 publications

References 30 publications

Antiepileptogenic and Neuroprotective Effects of Pergularia daemia on Pilocarpine Model of Epilepsy

Antiepileptogenic and Neuroprotective Effects of Pergularia daemia on Pilocarpine Model of Epilepsy

Anticonvulsant and Antioxidant Effects ofTilia americanavar.mexicanaand Flavonoids Constituents in the Pentylenetetrazole-Induced Seizures

Antioxidant and antikindling effect of Tapinanthus globiferus growing on Ficus glumosa in pentylenetetrazole induced kindled rats

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