Anti-epileptic drug utilization and treatment outcome among epileptic patients on follow-up in a resource poor setting

Gurshaw, Mesfin; Agalu, Asrat; Chanie, Tesfahun

doi:10.5530/jyp.2014.3.8

Cited by 22 publications

(42 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, the most commonly prescribed AED as monotherapy was phenobarbitone (81.8%) followed by phenytoin (15.4%). is is in line with the studies conducted in Jimma and Gonder, Ethiopia [17,18]. In contrast to this, a study done in the United Kingdom reported that the most commonly used AED was carbamazepine (37.4%) followed by sodium valproate (35.7%) [19].…”

Section: Discussionsupporting

confidence: 86%

Epilepsy Treatment Outcome and Its Predictors among Ambulatory Patients with Epilepsy at Mizan-Tepi University Teaching Hospital, Southwest Ethiopia

Zewudie

Mamo

Feyissa

et al. 2020

Neurology Research International

View full text Add to dashboard Cite

Background. Epilepsy is among the most common neurological disorders which is highly treatable with currently available antiepileptic drugs at a reasonable price. In Ethiopia, despite a number of studies revealed high prevalence of epilepsy, little is known on predictors of poorly controlled seizures. us, the aim of this study was to assess epilepsy treatment outcome and its predictors among patients with epilepsy on follow-up at the ambulatory care unit of Mizan-Tepi University Teaching Hospital, Southwest Ethiopia. Methods. A hospital-based cross-sectional study involving patient interview and chart review was conducted from March 10 to April 10, 2018. Drug use patterns and sociodemographic data of the study participants were accustomed to descriptive statistics. Backward logistic regression analysis was done to identify predictors of poor seizure control. Statistical significance was considered at p value <0.05. Results. From a total of 143 studied patients with epilepsy, 60.8% had uncontrolled seizures. Monotherapy (79%) was commonly used for the treatment of seizures, of which phenobarbital was the most commonly utilized single anticonvulsant drug (62.9%). e majority (72.7%) of the patients had developed one or more antiepileptic-related adverse effects. Medium medication adherence (adjusted odds ratio (AOR) � 5.4; 95% CI � 1.52-19.23; p � 0.009), poor medication adherence (AOR � 8.16; 95% CI � 3.04-21.90; p � 0.001), head injury before seizure occurrence (AOR � 4.9; 95% CI � 1. 25-19.27; p � 0.02), and seizure attacks ≥4 episodes/week before AEDs initiation (AOR � 8.52; % CI � 2.41-13.45; p � 0.001) were the predictors of uncontrolled seizure. Conclusions. Based on our findings, more than half of the patients with epilepsy had poorly controlled seizures. Nonadherence to antiepileptic drugs, high frequency of seizure attack before AEDs initiation, and history of a head injury before the occurrence of seizure were predictors of uncontrolled seizure. Patient medication adherence should be increased by the free access of antiepileptic drugs and attention should be given for the patients with a history of head injury and high frequency of seizure attacks before AEDs initiation.

show abstract

Section: Discussionsupporting

confidence: 86%

Epilepsy Treatment Outcome and Its Predictors among Ambulatory Patients with Epilepsy at Mizan-Tepi University Teaching Hospital, Southwest Ethiopia

Zewudie

Mamo

Feyissa

et al. 2020

Neurology Research International

View full text Add to dashboard Cite

show abstract

“…Another study in Bisho u general hospital also reported monotherapy users to be 78.6% [26] and a study done by Birru et al also found that 80.35% [27] of studied patients used single drug for treatment of their epilepsy. However Gurshaw et al reported only 54.5% of studied epileptic patients in Jimma university hospital used monotherapy [28].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Quality of Life of Epileptic Patients in Ethiopia

Muche

Ayalew

Abdela

2020

International Journal of Chronic Diseases

View full text Add to dashboard Cite

Background. Patients with epilepsy are at an increased risk of poor quality of life. Purpose. We aimed at assessing the quality of life and its determinants among epileptic patients at University of Gondar Referral Hospital (UoGRH), Ethiopia. Methods. Institution based cross-sectional study was conducted on epileptic patients on follow up at UoGRH from January 15 to April 15, 2017. Information including socio-demographic profile and diagnosis was extracted from medical records and patients. Quality Of Life In Epilepsy-10 (QOLIE-10) tool was used to measure the quality of life. Independent t-test and one-way analysis of variance were used to look for factors associated with quality of life. The level of statistical significance was declared at P-value ≤ 0.05. Results. A total of 354 patients were included in the study and mean age was 29.1 ± 11.7 years. The mean QOLIE-10 score was 19.85. One hundred ninety-four (54.8%) of participants had a good quality of life. Being illiterate, unemployment, and presence of co-morbid medical condition were associated with poorer quality of life. Conclusion. Nearly half of the participants had a poor quality of life. Patients with co-morbidity, illiteracy, and unemployment should be given special emphasis in order to improve their quality of life.

show abstract

“…Choice of the most appropriate AEDs depends on proper classification of seizures type. Lack of proper seizure classification affects AEDs selection and treatment outcome [22,23]. About 8% of the study participants had uncategorized seizure type, which could possibly have contributed to inappropriate drug selection and poor treatment outcomes.…”

Section: Discussionmentioning

confidence: 99%

Drug therapy problems and treatment satisfaction among ambulatory patients with epilepsy in a specialized hospital in Ethiopia

Nasir¹,

Berha²,

Gebrewold³

et al. 2020

PLoS ONE

View full text Add to dashboard Cite

Objective Epilepsy management especially in developing country is challenging. Seizures recurrence can be caused by both drug and non-drug related problems such as inadequate antiepileptic regimens, adverse drug reaction and poor adherence. Patient treatment satisfaction also affects the treatment out comes by improving medication adherence. This study aimed to assess drug therapy problems (DTPs) and treatment satisfaction among ambulatory epileptic patients at Tikur Anbessa Specialized Hospital. Methods A prospective cross-sectional study was conducted on 291 epileptic patients. Data was collected through patient interview and medical charts review. DTPs were identified based on the standard treatment guidelines and Micromedex® was used as drug interaction checker. Cipolle DTPs classification was used to classify the DTPs and Treatment Satisfaction with Medicine Questionnaire (SATMED-Q) was used to assess treatment satisfaction. Binary logistic regressions were utilized to identify the associated factors. Results Phenobarbital 195 (67%) and phenytoin 97 (33.3%) were the most frequently prescribed antiepileptic medications as monotherapy or combination therapy. Only 54 (18.6%) of the study participants had controlled seizure. DTP was found in 205(70.4%) of the study participants. From 352 DTPs identified, adverse drug reaction 146 (41.5%) was the leading DTPs followed by ineffective drugs 98 (27.8%) drug interaction 45 (12.8%) and inappropriate dose 42(11.9%). Headache, depression and epigastric pain were frequently reported adverse drug reaction. Among the study participants 167 (57.3%) were adherent to their medications. The number of medications taken by the patients had significant association with occurrence of DTPs, whereas source of medication and seizure free periods were found to have significant association with poor adherence. The global patient satisfaction was

show abstract

Anti-epileptic drug utilization and treatment outcome among epileptic patients on follow-up in a resource poor setting

Cited by 22 publications

References 12 publications

Epilepsy Treatment Outcome and Its Predictors among Ambulatory Patients with Epilepsy at Mizan-Tepi University Teaching Hospital, Southwest Ethiopia

Epilepsy Treatment Outcome and Its Predictors among Ambulatory Patients with Epilepsy at Mizan-Tepi University Teaching Hospital, Southwest Ethiopia

Assessment of Quality of Life of Epileptic Patients in Ethiopia

Drug therapy problems and treatment satisfaction among ambulatory patients with epilepsy in a specialized hospital in Ethiopia

Contact Info

Product

Resources

About