Anti-Endotoxin Therapy

Calandra, T.; Baumgartner, J. D.

doi:10.1007/978-3-642-79224-3_15

Cited by 9 publications

(2 citation statements)

References 51 publications

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“…Novel anti-inflammatory treatment regimens such as anti-tumor necrosis factor, anti-platelet-activating factor, anti-interleukin-1, anti-endotoxin, anti-bradykinin, inhibitors of nitric oxide synthase and steroids have also yielded disappointing results until now [1,2]. …”

Section: Introductionmentioning

confidence: 99%

“…Despite developing therapeutic strategies and new antibiotic regimens, mortality of sepsis and septic shock has actually remained at a level of about 35–50%. Novel anti-inflammatory treatment regimens such as anti-tumor necrosis factor, anti-platelet-activating factor, anti-interleukin-1, anti-endotoxin, anti-bradykinin, inhibitors of nitric oxide synthase and steroids have also yielded disappointing results until now [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

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The effects of IgM-enriched immunoglobulin preparations in patients with severe sepsis [ISRCTN28863830]

et al. 2002

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IntroductionDespite developing therapeutic strategies and new antibiotic regimens, mortality of sepsis and septic shock has actually remained at a level of about 35-50%. Novel anti-inflammatory treatment regimens such as anti-tumor necrosis factor, antiplatelet-activating factor, anti-interleukin-1, anti-endotoxin, anti-bradykinin, inhibitors of nitric oxide synthase and steroids have also yielded disappointing results until now [1,2]. APACHE II = acute physiological and chronic health evaluation II; ivIg = intravenous immunoglobulin; PCT = procalcitonin; SOFA = sequential organ failure assessment. AbstractIntroduction In this prospective, randomized controlled study, we aimed to evaluate the effect of IgMenriched immunoglobulin treatment on progression of organ failure and septic shock in patients with severe sepsis. Materials and methods Forty-two patients with severe sepsis were enrolled in the study. Patients in the study group (n = 21) received an intravenous immunoglobulin preparation (Pentaglobin ® ) in addition to standard therapy. Pentaglobin ® therapy was commenced on the day of diagnosis of severe sepsis: 5 ml/kg per day Pentaglobin ® (38 g/l IgG, 6 g/l IgM, and 6 g/l IgA) was infused over 6 hours and repeated for 3 consecutive days. Patients in the control group (n = 18) received standard sepsis therapy, but no immunoglobulin administration. Blood samples for procalcitonin (PCT) measurements were taken daily for 8 days. Severity of critical illness and development of organ failure were assessed by obtaining daily acute physiological and chronic health evaluation (APACHE) II and sequential organ failure assessment (SOFA) scores. Results and discussion Procalcitonin levels showed a statistically significant decrease in the Pentaglobin ® group (P < 0.001); however, an improvement in SOFA scores could not be demonstrated. Procalcitonin levels and SOFA scores did not change significantly in the control group. Septic shock incidence (38% versus 57%) and 28-day mortality rate (23.8% versus 33.3%) were found to be similar between the Pentaglobin ® and control groups. The evaluation of serial APACHE II scores did not demonstrate a difference between Pentaglobin ® and control groups either. Conclusion Present data could not demonstrate any beneficial effects of polyclonal immunoglobulin preparation Pentaglobin ® on organ morbidity, septic shock incidence and mortality rate in patients with severe sepsis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%