Anti-Dna Antibody Idiotypes in Sle

Isenberg, David; Shoenfeld, Yehuda; Fournie, GilbertJ.; Dueymes, J.M.; Gayral-Taminh, Martine; Pourrat, J.; Mignon-Conte, M; Conte, J. Le

doi:10.1016/s0140-6736(84)90753-0

Cited by 17 publications

(9 citation statements)

References 6 publications

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“…Recently, immunisation of naive mice with the 16/6 idiotype has been followed by induction of an SLE-like disease.29 31 3 Therefore, we expected increased titres of the 16/6 idiotype to be found in higher numbers in patients and first degree relatives in families with multiple cases of SLE in comparison with the incidences reported previously (40% and 25% respectively). 32 Conceivably, in the families reported here other pathogenic idiotypes might play a significant part. We have reported previously a pathogenetic role for the 16/6 idiotype in at least one family, but the members of that family had an additional risk factor for SLE-namely, C4 complement component deficiencies either at C4A or C4B.…”

Section: Discussionmentioning

confidence: 80%

Diversity and pattern of inheritance of autoantibodies in families with multiple cases of systemic lupus erythematosus.

Shoenfeld

Slor²,

Shafrir³

et al. 1992

Annals of the Rheumatic Diseases

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The pattern of inheritance of autoantibodies in eight families chosen from a pool of 110 families of patients with systemic lupus erythematosus (SLE) is described. In all the eight families at least two members were already affected by SLE. In total, 19 patients and 43 first degree relatives were examined.The inheritance of a large set of antinuclear antibodies (for example, DNA, Sm, RNP, Ro, La, histones) and 16/6 idiotype seemed to be related to some unknown genetic factors but not related to HLA. The presence of numerous antinuclear autoantibodies in the serum of a subject was not necessarily associated with overt disease. The incidence of the 16/6 idiotype among patients and their relatives was low.It is not yet clear whether the 'autoantibody burden' is greater in families with multiple cases of SLE than in families with single cases.

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Section: Discussionmentioning

confidence: 80%

Diversity and pattern of inheritance of autoantibodies in families with multiple cases of systemic lupus erythematosus.

Shoenfeld

Slor²,

Shafrir³

et al. 1992

Annals of the Rheumatic Diseases

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“…Antinuclear 17 (41%) were antinuclear antibody positive and 24 (59%) were antinuclear antibody negative. There was little evidence for the particular autoantibodies or idiotypes described here, even among the antinuclear antibody positive patients.…”

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confidence: 99%

Autoantibody and idiotype profile of lung involvement in autoimmune rheumatic disease.

Turner-Stokes

Haslam

Jones

et al. 1990

Annals of the Rheumatic Diseases

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“…Furthermore, l of the monoclonal anti-M tuberculosis antibodies was found to possess the common anti-DNA idiotype, 16/6 (10,12,13 …”

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confidence: 99%

A common anti‐dna idiotype in sera of patients with active pulmonary tuberculosis

Sela

El-Roeiy

Isenberg

et al. 1987

Arthritis & Rheumatism

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The sera of 51 patients with active, untreated pulmonary tuberculosis were examined for the presence of a common anti-DNA idiotype, 1616. Thirty-four of the 57 sera (60%) had an increased level of the idiotype, as measured by enzyme-linked immunosorbent assay using a specific rabbit anti-1616 serum. Of 28 matched control sera, only 1 (4%) was found to be positive for the idiotype, The sera of patients with tuberculosis also showed increased activity against a variety of antigens with which lupus autoantibodies are known to crossreact (e.g., single-stranded DNA, double-stranded DNA, polynucleotides, and cardiolipin). A correlation was observed between serum IgG and IgM levels and the 1616 idiotype levels.

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Anti-Dna Antibody Idiotypes in Sle

Cited by 17 publications

References 6 publications

Diversity and pattern of inheritance of autoantibodies in families with multiple cases of systemic lupus erythematosus.

Diversity and pattern of inheritance of autoantibodies in families with multiple cases of systemic lupus erythematosus.

Autoantibody and idiotype profile of lung involvement in autoimmune rheumatic disease.

A common anti‐dna idiotype in sera of patients with active pulmonary tuberculosis

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