Anti-DNA antibodies of IgA class in patients with systemic lupus erythematosus

Gripenberg, Marianne; Helve, T

doi:10.1007/bf00541504

Cited by 21 publications

(17 citation statements)

References 18 publications

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“…With the lower cutoff, the prevalence of IgA anti-dsDNA antibodies was 36.9%, with the higher cutoff 19.9%. In agreement with these data, in 33% to 63% of SLE sera IgA anti-dsDNA antibodies have been detected in previous ELISA assays using cutoffs, which are comparable to our lower cutoff [9,10].…”

Section: Discussionsupporting

confidence: 89%

“…Furthermore, no correlations of IgA anti-dsDNA antibodies with the symptoms proteinuria and increase of serum creatinine were found. Therefore, an association of lupus nephritis with IgA anti-dsDNA antibodies is unlikely, and differences from other studies are probably due to the larger patient population examined in this study compared to only small groups in previous studies [9,10]. Similarly, we could not find an association of IgA anti-dsDNA antibodies with arthritis.…”

Section: Discussioncontrasting

confidence: 79%

“…In this respect, IgA antibodies are comparable to IgG antidsDNA antibodies that have been shown to rise in parallel to an increasing disease activity. Several previous studies concluded that IgA anti-dsDNA antibodies were associated with lupus nephritis in general [9] or with active nephritis alone [10]. We therefore calculated associations both for the patients who fulfilled the criteria of active nephritis (either proteinuria > 0.5 g/day or erythrocyte cylinders in the urine sediment) at the time when the serum was drawn and for patients who had previous episodes of SLE nephritis, but did not show disease activity at the time when the serum was drawn.…”

Section: Discussionmentioning

confidence: 99%

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Association of IgA anti-dsDNA antibodies with vasculitis and disease activity in systemic lupus erythematosus

Witte

Hartung

Tenbusch³

et al. 1998

Rheumatology International

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Previously it has been suggested that the presence of antibodies against dsDNA of the IgA class may define a subset of systemic lupus erythematosus (SLE) patients suffering from nephritis and arthritis. Therefore, these autoantibodies were measured in sera of 352 patients with SLE, 81 blood donors, and 189 patients with rheumatoid arthritis using a new ELISA based on human recombinant dsDNA as antigen. IgA anti-dsDNA antibodies were found in 19.9% of the sera from patients with SLE, but in none of the sera from 81 normal controls and 189 patients with rheumatoid arthritis. The association of these autoantibodies with 31 clinical and 36 laboratory parameters was calculated. IgA anti-dsDNA antibodies were found to be associated with parameters of disease activity such as elevated erythrocyte sedimentation rate and consumption of complement component C3, and the clinical parameters vasculitis, with necrosis and erythema, but not with nephritis and arthritis. Therefore, IgA anti-dsDNA antibodies define a subset of SLE patients, and monitoring of IgA anti-dsDNA antibodies may be helpful as a prognostic parameter in patients with SLE.

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Section: Discussionsupporting

confidence: 89%

Section: Discussioncontrasting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

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Association of IgA anti-dsDNA antibodies with vasculitis and disease activity in systemic lupus erythematosus

Witte

Hartung

Tenbusch³

et al. 1998

Rheumatology International

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“…In fact, IgA autoantibodies are also detected in some SLE patients. 31,32 Therefore, B6.Sle1Sle3 strain may provide a unique model for studying lupus. The detailed mechanisms by which combination of Sle1 and Sle3 mediates more IgA production remain to be investigated.…”

Section: Discussionmentioning

confidence: 99%

Sle3 and Sle5 can independently couple with Sle1 to mediate severe lupus nephritis

Liu

et al. 2007

Genes Immun

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Genetic analyses of the lupus-prone NZM2410 mouse have identified multiple susceptibility loci on chromosome 7, termed Sle3 and Sle5. Both of these loci were contained within a large congenic interval, originally termed as Sle3 that strongly impacts a variety of myeloid and T-cell phenotypes and mediates fatal lupus nephritis when combined with Sle1. We have now produced two subcongenic strains, B6.Sle3 and B6.Sle5, carrying the Sle3 and Sle5 intervals separately and characterized their phenotypes as monocongenic strains and individually in combination with Sle1. Neither B6.Sle3 nor B6.Sle5 monocongenic strain develop severe autoimmunity; however, both of these intervals cause the development of severe glomerulonephritis when combined with Sle1. Thus, B6.Sle1Sle3 and B6.Sle1Sle5 exhibit splenomegaly, expansion of activated B and CD4 þ T-cell populations and high levels of IgG and IgM autoantibodies targeting multiple nuclear antigens, intact glomeruli and various other autoantigens. In addition, B6.Sle1Sle3 mice also produced higher levels of IgA antinuclear autoantibodies, which were implicated in the development of IgA nephropathy. Our results indicate that Sle3 and Sle5 can independently complement with Sle1, through shared and unique mechanisms, to mediate the development of severe autoimmunity.

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“…These autoantibodies are associated with lupus nephritis [5,6]. In addition, approximately 30% of the SLE patients develop anti-dsDNA antibodies of the IgA class.…”

Section: Introductionmentioning

confidence: 99%

IgM anti-dsDNA antibodies in systemic lupus erythematosus: negative association with nephritis

Witte¹,

Hartung

Sachse

et al. 1998

Rheumatology International

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Antibodies against dsDNA of the IgM class were measured in sera of 352 patients with systemic lupus erythematosus, 81 blood donors and 189 patients with rheumatoid arthritis using a new ELISA based on human recombinant dsDNA as antigen. IgM anti-dsDNA antibodies were found in 52.3% of the sera from patients with systemic lupus erythematosus, but in none of the sera from 81 normal controls and 189 patients with rheumatoid arthritis. The association of these autoantibodies with 31 clinical and 37 laboratory parameters was calculated. There was a highly significant negative correlation between IgM anti-dsDNA antibodies and nephritis as well as all the laboratory parameters indicating renal disease (elevated serum creatinine concentration, proteinuria, erythrocyte casts in the urine). IgM anti-dsDNA antibodies indicate protection of lupus patients against the development of lupus nephritis. Further experiments will show whether application of IgM anti-dsDNA antibodies is effective in treating lupus nephritis.

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Anti-DNA antibodies of IgA class in patients with systemic lupus erythematosus

Cited by 21 publications

References 18 publications

Association of IgA anti-dsDNA antibodies with vasculitis and disease activity in systemic lupus erythematosus

Association of IgA anti-dsDNA antibodies with vasculitis and disease activity in systemic lupus erythematosus

Sle3 and Sle5 can independently couple with Sle1 to mediate severe lupus nephritis

IgM anti-dsDNA antibodies in systemic lupus erythematosus: negative association with nephritis

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