Anti-diarrhoeal evaluation of Clerodendrum phlomidis Linn. leaf extract in rats

Rani, Sheba; Ahamed, Nazeer; Sangeetha, R.; Saluja, Radha; Thenmozhi, S.; Murugesan, T.

doi:10.1016/s0378-8741(99)00103-8

Cited by 42 publications

(30 citation statements)

References 3 publications

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“…The genus Clerodendron, is reported to demonstrate biological activities such as antitumorgenic [7,8] , Hypoglycemic, hypolipidemic [5,9] , Hepatoprotective activity against CCl 4 induced liver injury in rats [10,11] , Anti-inflammatory [12][13][14] , free radicalscavenging activity, Anti-diarrhoeal, Antinociceptive and antipyretic effects [15][16][17] . To the best of our knowledge, there is only one scientific report published regarding the phytomedicinal properties of CC by Adeneye et al [6] .…”

Section: Introductionmentioning

confidence: 99%

Serotonergic Properties of the Roots of Clerodendron capitatum

Ibrahim¹,

Wahab²,

Mohamed³

et al. 2008

American J. of Biochemistry and Biotechnology

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Abstract:The aim of this study is to investigate the pharmacological effects of the methanolic extract of Clerodendron capitatum, CC, (family verbenaceae). These investigations were carried out on isolated frog rectus abdominus muscle and rabbit aortic strips and jejunum and non-pregnant rat uterus pretreated with oestradiol. Results showed that CC did not demonstrate any contracting, relaxant or blocking effects on frog rectus abdominus muscle and rat aortic strip preparations. The extract produced a concentration-dependent (p<0.05, t-test, n = 6) decrease of the normal rhythmic contraction of rabbit jejunum, however, this effect was reversed by prior addition of cyproheptadine (non-specific 5-HT antagonist). In addition, CC also produced a stimulant activity on rat uterus which was blocked by cyproheptadine. Future study is recommended to study the specificity of CC to different 5-HT receptors by using different isolated animal tissues and specific 5-HT antagonists.

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Section: Introductionmentioning

confidence: 99%

Serotonergic Properties of the Roots of Clerodendron capitatum

Ibrahim¹,

Wahab²,

Mohamed³

et al. 2008

American J. of Biochemistry and Biotechnology

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“…Traditionally, Clerodendrum phlomidis Linn F. (Lamiaceae) leaf extract is used to treat skin diseases in livestock (Ramji 1992). C. phlomidis is used as an astringent and also to treat gonorrhea (Rani et al 1999;Murugesan et al 2001). C. phlomidis (C. multiflorum) has been used as botanical pesticide to control aphids and red hairy caterpillar, Amsacta albistriga (Walker, 1865) (Upadhyay et al 2002;Singh and Saratchandra 2005).…”

Section: Napal Et Al (2009) Isolated Flavonoids Frommentioning

confidence: 99%

Bioefficacy of pectolinaringenin from Clerodendrum phlomidis Linn. F. against Anopheles stephensi and bhendi fruit borer, Earias vittella fab.

Muthu¹,

Baskar²,

Duraipandiyan

et al. 2015

Braz. arch. biol. technol.

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“…The leaves and roots are used in Ayurveda, Siddha, Chinese and Unani medicines [9]. C. phlomidis leaf has been reported for various biological activities such as antifungal [10], antioxidant [11], antibacterial [11], analgesic [12], antiasthmatic [13], antidiarrheal [14], anti-inflammatory [15], antiplasmodial [16], and hypoglycemic [17]. The methanol extract of C. phlomidis leaf has been reported for cytotoxicity [18].…”

Section: Introductionmentioning

confidence: 99%

In-Vitro Cytotoxic and Apoptosis Study of Chemical Constituents of Clerodendrum Phlomidis Leaf on McF-7 Breast and a-549 Lung Cancer Cell Lines.

Raja

2018

Asian J Pharm Clin Res

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Objective: Cancer is a molecularly heterogeneous diseaseand the leading cause of death worldwide. The methanol extract of Clerodendrum phlomidis leaf has been reported for cytotoxicity. Hence, the current investigation was planned to evaluate the cytotoxic activity of the chemical constituents isolated from the methanol extract of the C. phlomidis leaf against the Michigan cancer foundation-7 (MCF-7) breast cancer and adenocarcinomic human alveolar basal epithelial cells (A549) lung cancer cell lines by the apoptotic study.Methods: Cytotoxic activity of the chemical constituents of the methanol extract of the C. phlomidis leaf was evaluated by the 3-(4,5-dimethylthiazol-2-yl)-5-diphenyltetrazolium bromide (MTT) assay against breast cancer (MCF-7) and lung cancer (A549) cell lines. The MCF-7 and A549 cell lines were tested at different concentrations to determine 50% of growth inhibition (inhibitory concentration [IC 50 ]) by MTT assay. Apoptosis of nuclei was detected by 4',6-diamidino-2-phenylindole staining assay. Results:In MCF-7 breast cancer cell line study, Compounds 6 and 9 exhibited good cytotoxic activity with an IC 50 value of 83.80 and 75.16 µg/ml, respectively. In A549 lung cancer cell line, again Compounds 6 and 9 exhibited good cytotoxic activity with an IC 50 value of 84.46 and 78.60 µg/ml, respectively. Percentage of apoptosis induced by the Compounds 6 and 9 in the MCF-7 cancer cells was found to be 74.50 and 85.48, respectively. Conclusion:The results of the current study prove that the Compounds 6 and 9 are potential agents for breast and lung cancer. In future research, these potential agents can further be evaluated by animal studies and their mechanism of action apart from the induction of apoptosis of the cancer cells can be determined.

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Anti-diarrhoeal evaluation of Clerodendrum phlomidis Linn. leaf extract in rats

Cited by 42 publications

References 3 publications

Serotonergic Properties of the Roots of Clerodendron capitatum

Serotonergic Properties of the Roots of Clerodendron capitatum

Bioefficacy of pectolinaringenin from Clerodendrum phlomidis Linn. F. against Anopheles stephensi and bhendi fruit borer, Earias vittella fab.

In-Vitro Cytotoxic and Apoptosis Study of Chemical Constituents of Clerodendrum Phlomidis Leaf on McF-7 Breast and a-549 Lung Cancer Cell Lines.

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