Anti-diarrhoeal activity of Butea monosperma in experimental animals

Gunakkunru, A.; Padmanaban, K.; Thirumal, P.; Pritila, J.; Parimala, G.; Vengatesan, N.; Gnanasekar, N; Perianayagam, James B.; Sharma, Sunny; Pillai, K. K.

doi:10.1016/j.jep.2004.12.021

Cited by 42 publications

(29 citation statements)

References 7 publications

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“…(Prasad et al, 2006). From the flowers of BM, flavonoids like butin (Barwick, 2004), butein (Jayaweera, 1981), butrin (Somani et al, 2006), isobutrin, palasitrin, coreopsin, isocoreopsin, sulphuresin, monospermoside (Mengi and Deshpande, 1999), isomonospermoside (Somani et al, 2004) and 7,3 ,4 -trihydroxyflavone (Gunakkunru et al, 2005) have been isolated. The BM extracts exhibited other biological activities including aphrodisiac activity in male rats (Ramachandran et al, 2004), anthelmintic activity (Prashanth et al, 2001;Iqbal et al, 2006) and dermal wound healing in rats (Sumitra et al, 2005).…”

Section: Butea Monosperma Lam (Fabaceae)mentioning

confidence: 99%

Potential antifertility agents from plants: A comprehensive review

Kumar

Prakash

2012

Journal of Ethnopharmacology

116

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Section: Butea Monosperma Lam (Fabaceae)mentioning

confidence: 99%

Potential antifertility agents from plants: A comprehensive review

Kumar

Prakash

2012

Journal of Ethnopharmacology

116

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“…Traditionally, most of the plant parts are used for the treatment of various inflammatory, metabolic, and infectious diseases. The plant constituents have been reported to possess hepatoprotective (Wagner et al, 1986), anti-inflammatory (Shahavi and Desai, 2008), antidiabetic (Somani et al, 2006), antihelmintic (Iqbal et al, 2006), antidiarrheal (Gunakkunru et al, 2005), antifungal (Yadava and Tiwari, 2007), and antimicrobial (Gurav et al, 2008) activities. In short, approximately 45 medicinal uses are associated with this plant, and half of the number of claims have been scientifically studied and reported in the literature (Burli and Khade, 2007).…”

mentioning

confidence: 99%

Butrin, Isobutrin, and Butein from Medicinal PlantButea monospermaSelectively Inhibit Nuclear Factor-κB in Activated Human Mast Cells: Suppression of Tumor Necrosis Factor-α, Interleukin (IL)-6, and IL-8

Rasheed¹,

Akhtar²,

Khan³

et al. 2010

J Pharmacol Exp Ther

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Activation of mast cells in rheumatoid synovial tissue has often been associated with tumor necrosis factor (TNF)-␣, interleukin (IL)-6, and IL-8 production and disease pathogenesis by adjacent cell types. Butea monosperma (BM) is a well known medicinal plant in India and the tropics. The aim of this study was to examine whether a standardized extract of BM flower (BME) could inhibit inflammatory reactions in human mast cells (HMC) using activated HMC-1 cells as a model. Four previously characterized polyphenols-butrin, isobutrin, isocoreopsin, and butein-were isolated from BME by preparative thin layer chromatography, and their purity and molecular weights were determined by liquid chromatography/mass spectrometry analysis. Our results showed that butrin, isobutrin, and butein significantly reduced the phorbol 12-myristate 13-acetate and calcium ionophore A23187-induced inflammatory gene expression and production of TNF-␣, IL-6, and IL-8 in HMC-1 cells by inhibiting the activation of NF-B. In addition, isobutrin was most potent in suppressing the NF-B p65 activation by inhibiting IB␣ degradation, whereas butrin and butein were relatively less effective. In vitro kinase activity assay revealed that isobutrin was a potent inhibitor of IB kinase complex activity. This is the first report identifying the molecular basis of the reported anti-inflammatory effects of BME and its constituents butrin, isobutrin, and butein. The novel pharmacological actions of these polyphenolic compounds indicate potential therapeutic value for the treatment of inflammatory and other diseases in which activated mast cells play a role.

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“…11) Isolation of (Ϫ)-medicarpin with antifungal activity from this part of the plant has also been reported. 12) From the flowers of this plant species the flavonoids butin (1), butein (2), butrin (3), isobutrin, palasitrin, coreopsin, isocoreopsin, sulphuresin, monospermoside (4), isomonospermoside (5) and 7,3Ј,4Ј-trihydroxyflavone (6) have been isolated. [13][14][15] Antihepatotoxic activity of the flower extract 16) and of compound 3 and isobutrin 17) has been observed.…”

mentioning

confidence: 99%

Bioactive Flavonoids of the Flowers of Butea monosperma

et al. 2009

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Butea monosperma (LAM.) TAUB. (Fabaceae), known in Thai as Tong-kwoaw, is a medium sized deciduous tree of up to 50 feet high with stunning flower clusters, very conspicuous when in flower, and the trunk is usually crooked and twisted with irregular branches and rough, grey bark. The flowers are bright orange red, large and in rigid racemes. 1)This plant species has been found to display a wide variety of biological activities. The stem bark is used in indigenous medicine for the treatment of dyspepsia, diarrhea, dysentery, diabetes, ulcers, sore throat and snake bites.2) The flower extract showed antidiabetic effect in rats.3) The plant leaves exhibited antiinflammatory effect 4) and exerted effect on stress, anxiety and cognition in rats.5) Anti-diarrhoeal activity of the ethanolic extract of the stem bark 6) and anticonvulsive activity of the petroleum ether extract of the flowers 7) of this plant species in experimental animals have been reported. The plant extracts exhibited other biological activities including aphrodisiac activity in male rats, 8) anthelmintic activity, 9,10) and dermal wound healing in rats. 11) Isolation of (Ϫ)-medicarpin with antifungal activity from this part of the plant has also been reported. 12) From the flowers of this plant species the flavonoids butin (1), butein (2), butrin (3), isobutrin, palasitrin, coreopsin, isocoreopsin, sulphuresin, monospermoside (4), isomonospermoside (5) and 7,3Ј,4Ј-trihydroxyflavone (6) have been isolated. [13][14][15] Antihepatotoxic activity of the flower extract 16) and of compound 3 and isobutrin 17) has been observed. Compound 1 which was isolated from the seeds of this plant species showed estrogenic and postcoital anti-conceptive activity in rats.18) A lectin was also isolated from the seeds and was found to agglutinate human erythrocytes. The activity was inhibited by N-acetyl galactosamine and did not require a divalent ion.19) The euphane triterpenoid 3a-hydroxyeuph-25-ene and the alcohol 2,14-dihydroxy-11,12-dimethyl-8-oxo-octadec-11-enylcyclohexane have been isolated from the stem.20) The imide palasimide has been isolated from the pods of this plant species.21) Stigmasterol, stigmasterol-3-O-b-D-glucopyranoside and nonacosanoic acid were also among those isolated compounds. 15,20) As part of an ongoing project on bioactive compounds from Thai medicinal plants for the treatments of tropical diseases, the plant species was investigated and it was found that the EtOAc and MeOH extracts exhibited antimycobacterial activity. The present report deals with the One new dihydrochalcone, dihydromonospermoside (7), was isolated from the flowers of Butea monosperma together with three known chalcones, butein (2), monospermoside (4) and isoliquiritigenin (8), one flavone, 7,3 ,4 -trihydroxyflavone (6), four flavanones, (؊)-butin (1a), (؊)-butrin (3a), (؉)-isomonospermoside (5b) and (؊)-liquiritigenin (9a), and three isoflavones, formononetin (10), afrormosin (11) and formononetin-7-O-b b-D-glucopyranoside (12). The structure of the new compound was e...

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Anti-diarrhoeal activity of Butea monosperma in experimental animals

Cited by 42 publications

References 7 publications

Potential antifertility agents from plants: A comprehensive review

Potential antifertility agents from plants: A comprehensive review

Butrin, Isobutrin, and Butein from Medicinal PlantButea monospermaSelectively Inhibit Nuclear Factor-κB in Activated Human Mast Cells: Suppression of Tumor Necrosis Factor-α, Interleukin (IL)-6, and IL-8

Bioactive Flavonoids of the Flowers of Butea monosperma

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