Anti-diarrheal effect of Galla Chinensis on the Escherichia coli heat-labile enterotoxin and ganglioside interaction

Chen, Jaw-Chyun; Ho, Tin-Yun; Chang, Yuan‐Shiun; Wu, Shih-Lu; Hsiang, Chien-Yun

doi:10.1016/j.jep.2005.08.036

Cited by 60 publications

(62 citation statements)

References 34 publications

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“…This will lead to decreased absorption and cause diarrhoea. Previous reports have demonstrated that gallic acid and chebulinic acid have anti-secretory activity by inhibiting H + K + -ATPase activity (Chen et al 2006;Mishra et al 2013). In this study, phytochemical analysis of the antidiarrhoeal fraction revealed that the presence of the hydrolysable tannins, including gallic acid, 3,4,6-tri-Ogalloyl-b-D-Glc, corilagin and ellagic acid.…”

Section: Discussionmentioning

confidence: 51%

Assessment of the antidiarrhoeal properties of the aqueous extract and its soluble fractions of Chebulae Fructus (Terminalia chebula fruits)

Sheng

Yan

Zhang

et al. 2016

Pharmaceutical Biology

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Context Chebulae Fructus is used as an herbal remedy for diarrhoea in traditional Chinese medicine. However, there is no scientific evidence to support its antidiarrhoeal activity. Objective This study evaluates the antidiarrhoeal properties of Chebulae Fructus aqueous extract (CFAE) and determines the active fraction. Materials and methods The antidiarrhoeal effect of CFAE (200-800 mg/kg) was investigated by determining the wet dropping, intestinal transit in BALB/c mice and enteropooling in Wister rats. The protective effects of the CFAE on the intestinal and liver were tested by histopathological analyses. The antidiarrhoeal fraction was determined by castor oil-induced diarrhoea and its main constituents were identified by HPLC-ESI-MS.Results The extract at doses of 200, 400 and 800 mg/kg reduced the diarrhoea by 9.1, 40.0 and 58.2% and inhibited intestinal transit by 18.3, 24.1 and 35.7%, respectively. Additionally, the CFAE (200, 400 and 800 mg/kg) decreased the volume of enteropooling by 47.1, 58.8 and 64.7%, respectively. Mice treated with castor oil presented morphological alterations in the small intestine and the liver. However, the lesions of mice treated with CFAE were alleviated. Moreover, the ethyl acetate fraction was the active fraction of CFAE, the fraction (41.7, 83.4 and 166.8 mg/kg) reduced the diarrhoea by 9.1, 38.2 and 54.5%, respectively. The major components of the ethyl acetate fraction were tannins, including gallic acid, 3, 4, 6-tri-O-galloyl-b-D-Glc, corilagin and ellagic acid according to the HPLC-ESI-MS analysis. Conclusion The CFAE possessed antidiarrhoeal property and the ethyl acetate fraction was its main active fraction. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 51%

Assessment of the antidiarrhoeal properties of the aqueous extract and its soluble fractions of Chebulae Fructus (Terminalia chebula fruits)

Sheng

Yan

Zhang

et al. 2016

Pharmaceutical Biology

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“… Galla chinensis and Chaenomeles speciosa have been traditionally used in China to treat gastrointestinal disorders. These plant extracts significantly inhibited heat-labile enterotoxin-induced diarrhoea in the mouse (Chen et al, 2006, Chen et al, 2007.  Satureja hortensis is an annual herb that is traditionally used in Iran for treating stomach and intestinal disorders.…”

Section: Plants Tested For Antidiarrheal Activity In Animal Models Ofmentioning

confidence: 99%

Pharmacology of Traditional Herbal Medicines and Their Active Principles Used in the Treatment of Peptic Ulcer, Diarrhoea and Inflammatory Bowel Disease

Kota¹,

Teoh²,

Roufogalis³

2012

New Advances in the Basic and Clinical Gastroenterology

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“…9,41 Gallic acid has already been cited for its antidiarrheic activity. 42 The layer formed by proteins precipitated on the mucosal surface of the enterocytes can also inhibit the development of microorganisms, contributing to the antiseptic action of the tannins and aiding the treatment of diarrhea. 9 Because derivatives of tannins were observed in the fruit and leaf extracts of P. cauliflora, an antidiarrheal effect could be expected in this plant material.…”

Section: Figmentioning

confidence: 99%

Chemical and Antidiarrheal Studies ofPlinia cauliflora

Souza-Moreira

Severi

Santos

et al. 2011

Journal of Medicinal Food

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Plinia cauliflora (Mart.) Kausel, widespread in South America, has edible fruits, and its bark is commonly used against diarrhea and other disorders, on account of its astringency. Because diarrhea is still one of the most important causes of illness and death among children in developing countries, where the population turns to traditional medicine for its treatment, the present study determined the composition of fruit and leaf extracts of P. cauliflora, analyzed the activity against diarrhea by antimicrobial and gastrointestinal motility, and evaluated the cytotoxicity of the extracts. Chemical composition was determined by high-performance liquid chromatograpy-ultraviolet/photodiode array detection. Antimicrobial activity was analyzed by agar diffusion and the microdilution method against etiological agents of diarrhea. The effect on gastrointestinal motility was analyzed using an experimental model in mice. Cytotoxicity was evaluated in vitro with the fibroblast cell line SIRC CCL 60, and leaf extract showed a 50% inhibitory concentration of 0.48 lg/mL. Gallic acid, ellagic acid, and flavonoid derivatives were detected in the extracts. It was observed that fruit and leaf extracts showed some activity against Enterococcus faecalis, Escherichia coli, Salmonella sp., and Shigella sp. However, neither extract had any effect on gastrointestinal motility.

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Anti-diarrheal effect of Galla Chinensis on the Escherichia coli heat-labile enterotoxin and ganglioside interaction

Cited by 60 publications

References 34 publications

Assessment of the antidiarrhoeal properties of the aqueous extract and its soluble fractions of Chebulae Fructus (Terminalia chebula fruits)

Assessment of the antidiarrhoeal properties of the aqueous extract and its soluble fractions of Chebulae Fructus (Terminalia chebula fruits)

Pharmacology of Traditional Herbal Medicines and Their Active Principles Used in the Treatment of Peptic Ulcer, Diarrhoea and Inflammatory Bowel Disease

Chemical and Antidiarrheal Studies ofPlinia cauliflora

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