Anti-Diarrheal Activity Of The Leaf Extracts Of <i>Daniellia oliveri</i> Hutch And Dalz (Fabaceae) And <i>Ficus sycomorus </i> Miq (Moraceae)

Abstract

The leaves of the plants Daniellia oliveri (Fabaceae) and Ficus sycomorus(Moraceae) used in diarrhea treatment in Hausa ethnomedicine of Northern Nigeria were investigated. The study was carried out on parfused isolated rabbit jejunum and castor oil-induced diarrhea in mice. The n-butanol extracts: NBD and NBF (0.16-3.2mg/ml) caused a dose-dependent relaxation of isolated rabbit jejunum. The acute toxicity test for NBD and NBT in mice established an i.p LD 50 of > 4000mg/kg for D. oliveri and 1131.4mg/kg for F. sycomorus. In castor oilinduced diarrhea, 80% protection was observed for D. oliveri at doses of 200mg/kg and 60% protection was observed at 100mg/kg and 50mg/kg respectively. For F. sycomorus 100% protection was observed at doses of 120mg/kg and 60mg/kg, for the n-butanol extract. The antidiarrheal activity was comparable to loperamide 5mg/kg. The result revealed that the extracts have pharmacological activity against diarrhea.

Approches de régénération artificielle de Daniellia oliveri (Rolfe) Hutchison et Dalziel

“…Divers organes de l'espèce sont utilisés pour leurs propriétés médicinales (Jegede et al, 2006 ;Ahmadua et al, 2007). Les feuilles et les fleurs sont utilisées comme fourrages en zone soudano-sahélienne (Lykke, 2000) et le bois comme matériau de construction et combustible (Lykke, 2000 ;FAO, 2001b).…”

Comparative Phytochemical, Antioxidant and Antimicrobial Properties of Ficus capensis, Aristolochia ringens, Albizia zygia and Lannea welwitschii

“…The leaves and roots of the plant are traditionally used for the treatment of leprosy, tuberculosis, sexually transmitted diseases, convulsions, wounds, diarrhea and dysentery. [15][16][17][18][19] The phytochemical screening, antioxidant and antimicrobial properties of the leaf extracts have been reported. 20,21 In another study, the phytochemical screening and microbial inhibitory activities of the leaf, stem and bark of F. capensis were also investigated 22 .…”

Macro- And Micromorphology of the Leaves, Inflorescences and Fruits of Ficus Sycomorus L. Cultivated in Egypt: Part 1

“…The extracts of the fruits, leaves, stem and root barks usually administered in the form of infusions, decoctions, tinctures, syrups and lotions have been used in the treatment of many diseases and disorders such as tuberculosis, inflammations, dysentery, diarrhea, cough, chest and mental disorders, skin infections and helminthiasis 14&15 . Also, the plant was reported to have antimicrobial [16][17][18] , analgesic and anti-inflammatory 19 , antidiarrheal 20 , antioxidant 21 , hepatoprotective 15&22 , sedative and anticonvulsant 23 , antitumor 24 , antidiabetic 25 and muscle relaxant activities 26 in addition to insecticidal and acaricidal properties 27 .…”