Anti-diabetic potential of Urtica Dioica: current knowledge and future direction

Chehri, Anita; Yarani, Reza; Yousefi, Zahra; Bahador, Tannaz Novin; Shakouri, Seyed Kazem; Ostadrahimi, Alireza; Mobasseri, Majid; Pociot, Flemming; Araj‐Khodaei, Mostafa

doi:10.1007/s40200-021-00942-9

Cited by 6 publications

(4 citation statements)

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“…The various phytochemicals in the UD, MC, and MK extracts that are responsible for their antioxidant and protective potential have been well identified. UD has been extensively studied and has shown prominent results in the treatment of prostate enlargement [ 13 ], preventing colon carcinogenesis in rats [ 14 ], and providing a protective effect against hyperglycemia [ 15 ], hypertension [ 16 ], and hypercholesterolemia [ 17 ]. Numerous studies have shown that MC counteracts diabetes by controlling GLP-1, which is essential for promoting insulin gene transcription [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…The phytochemicals of these three herbs, such as quercetin, polyphenols, alkaloids, reducing sugars, and vitamins, are known for their protective effects. UD has been extensively studied and has shown promising results in the treatment of prostate enlargement [ 13 ], colon carcinogenesis in rats [ 14 ], and protecting against hyperglycemia [ 15 ], hypertension, [ 16 ] and hypercholesterolemia [ 17 ]. Several studies have demonstrated the beneficial effects of MC against diabetes by regulating GLP-1, which is crucial in stimulating insulin gene transcription [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Ethnopharmacological Effects of Urtica dioica, Matricaria chamomilla, and Murraya koenigii on Rotenone-Exposed D. melanogaster: An Attenuation of Cellular, Biochemical, and Organismal Markers

et al. 2022

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Natural antioxidants derived from plants have been proven to have significant inhibitory effects on the free radicals of living organisms during actively metabolization. Excessive production of free radicals increases the risk of neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and motor sclerosis. This study aimed to compare the ethnopharmacological effects of Urtica dioica (UD), Matricaria chamomilla (MC), and Murraya koenigii (MK) on the amelioration of rotenone-induced toxicity in wild-type Drosophila melanogaster (Oregon R+) at biochemical, cellular, and behavioral levels. Phytoextracts were prepared from all three plants, i.e., UD, MC, and MK (aqueous and ethanolic fractions), and their bioactive compounds were evaluated using in vitro biochemical parameters (DPPH, ABTS, TPC, and TFC), UV-Vis, followed by FT-IR and HPLC. Third instar larvae and freshly eclosed flies were treated with 500 µM rotenone alone or in combination with UD, MC, and MK for 24 to 120 h. Following exposure, cytotoxicity (dye exclusion test), biochemical (protein estimation and acetylcholinesterase inhibition assays), and behavioral assays (climbing and jumping assays) were performed. Among all three plant extracts, MK exhibited the highest antioxidant properties due to the highest TPC, TFC, DPPH, and ABTS, followed by UD, then MC. The overall trend was MK > UD > MC. In this context, ethnopharmacological properties mimic the same effect in Drosophila, exhibiting significantly (p < 0.05) reduced cytotoxicity (trypan blue), improved biochemical parameters (proteotoxicity and AChE activity), and better behavioral parameters in the organisms cotreated with phyto extracts compared with rotenone. Conclusively, UV-Vis, FTIR, and HPLC analyses differentiated the plant extracts. The findings of this research may be beneficial in the use of select herbs as viable sources of phyto-ingredients that could be of interest in nutraceutical development and various clinical applications.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ethnopharmacological Effects of Urtica dioica, Matricaria chamomilla, and Murraya koenigii on Rotenone-Exposed D. melanogaster: An Attenuation of Cellular, Biochemical, and Organismal Markers

et al. 2022

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“…There is no study related to the effect of nettle on glucose, cholesterol, and triglyceride in rainbow trout to check the glucose- and lipid-lowering effects of this herb. The glucose-lowering effect of nettle was reviewed in mammal studies [ 61 ]. Furthermore, many studies have reported the lipid-lowering effect of this herb in a mammal, which reduces cholesterol, low-density lipoproteins, and triglyceride in blood and improves high-density lipoproteins [ 62 ].…”

Section: Effects Of Nettle On Hematological and Blood Biochemical Par...mentioning

confidence: 99%

Nettle (Urtica dioica) Additive as a Growth Promoter and Immune Stimulator in Fish

Zare

Esmaeili

Paolacci

et al. 2023

Aquaculture Nutrition

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Aquaculture will become an important food production sector for humans in the coming decades. However, disease outbreaks can be considered a significant obstacle to continually developing aquaculture. Plant powders and extracts are natural feed additives that, due to their bioactive compounds, including phenolic compounds, proteins, vitamins, and minerals, have antistress, antiviral, antibacterial, and antifungal effects on fish. One of these herbs is nettle (Urtica dioica), which has a long history of being used in traditional medicine. While it has been widely investigated in mammalian medicine, few studies have been done on aquaculture species. The positive effect of this herb on the growth performance, hematology, blood biochemistry, and immune system of fish species has been observed. When fish were exposed to pathogens, nettle-fed fish showed a higher survival rate and less stress than controls. Therefore, this literature review is aimed at reviewing the use of this herb in fish diets and its impacts on growth performance, hematology, blood biochemistry, liver enzymes, immune system stimulation, and challenges with pathogens.

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“…By reducing and chelating metal ions, scavenging free radicals, reducing lipids, and interacting favorably with antioxidant enzymes, these plants have powerful antioxidant potential [ 34 ]. UD has undergone significant research and has demonstrated good outcomes in rat colon carcinogenesis [ 35 ], the management of prostate enlargement [ 36 ], prevention of hypercholesterolemia [ 37 ] and hyperglycemia [ 38 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Green Engineered Silver Nanoparticles through Urtica dioica: An Inhibition of Microbes and Alleviation of Cellular and Organismal Toxicity in Drosophila melanogaster

et al. 2022

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Plant fractions have a diversity of biomolecules that can be used to make complicated reactions for the bioactive fabrication of metal nanoparticles (NPs), in addition to being beneficial as antioxidant medications or dietary supplements. The current study shows that Urtica dioica (UD) and biologically synthesized silver nanoparticles (AgNPs) of UD have antibacterial and antioxidant properties against bacteria (Escherichia coli and Pseudomonas putida) and Drosophila melanogaster (Oregon R+). According to their ability to scavenge free radicals, DPPH, ABTS, TFC, and TPC initially estimated the antioxidant potential of UD and UD AgNPs. The fabricated AgNPs were analyzed (UV‒Vis, FTIR, EDS, and SEM) to determine the functional groups (alcohol, carboxylic acids, phenol, proteins, and aldehydes) and to observe the shape (agglomerated crystalline and rod-shaped structure). The disc diffusion method was used to test the antimicrobial properties of synthesized Ag-NPs against E. coli and P. putida. For 24 to 120 h, newly enclosed flies and third instar larvae of Drosophila were treated with UD and UD AgNPs. After exposure, tests for biochemical effects (acetylcholinesterase inhibition and protein estimation assays), cytotoxicity (dye exclusion), and behavioral effects (jumping and climbing assays) were conducted. The results showed that nanoparticles were found to have potent antimicrobial activity against all microbial strains tested at various concentrations. In this regard, ethno-medicinal characteristics exhibit a similar impact in D. melanogaster, showing (p < 0.05) significantly decreased cellular toxicity (trypan blue dye), enhanced biochemical markers (AChE efficacy and proteotoxicity), and improved behavioral patterns in the organism treated with UD AgNPs, especially in comparison to UD extract. The results of this study may help in the utilization of specific plants as reliable sources of natural antioxidants that may have been beneficial in the synthesis of metallic NPs, which aids in the production of nanomedicine and other therapeutic applications.

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Anti-diabetic potential of Urtica Dioica: current knowledge and future direction

Cited by 6 publications

References 58 publications

Ethnopharmacological Effects of Urtica dioica, Matricaria chamomilla, and Murraya koenigii on Rotenone-Exposed D. melanogaster: An Attenuation of Cellular, Biochemical, and Organismal Markers

Ethnopharmacological Effects of Urtica dioica, Matricaria chamomilla, and Murraya koenigii on Rotenone-Exposed D. melanogaster: An Attenuation of Cellular, Biochemical, and Organismal Markers

Nettle (Urtica dioica) Additive as a Growth Promoter and Immune Stimulator in Fish

Synthesis of Green Engineered Silver Nanoparticles through Urtica dioica: An Inhibition of Microbes and Alleviation of Cellular and Organismal Toxicity in Drosophila melanogaster

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