Anti-diabetic potential of ursolic acid stearoyl glucoside: A new triterpenic gycosidic ester from Lantana camara

Kazmi, Imran; Rahman, Mahfoozur; Afzal, Muhammad; Gupta, Gaurav; Saleem, Sadaf; Afzal, Obaid; Shaharyar, Md. Adil; Nautiyal, Ujjwal; Ahmed, Shamim; Anwar, Firoz

doi:10.1016/j.fitote.2011.10.004

Cited by 71 publications

(34 citation statements)

References 32 publications

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“…Comparison of TTS and ethanol extract clearly reflects that antidiabetic activity of the extract is due to the major presence of a triterpenoid. Triterpenoid is well known for its antidiabetic activity (de Melo et al, 2010;Kazmi et al, 2012;Ramirez-Espinosa et al, 2011;Sarabu & Tilley, 2005). Triterpenoids can reduce blood glucose through increased insulin secretion, as evidenced in our experiment by STZ-induced diabetic rats, which is capable of modulating pancreatic secretion.…”

supporting

confidence: 52%

Antidiabetic potential of triterpenoid saponin isolated fromPrimula denticulate

Singh

Farswan²,

Ali³

et al. 2014

Pharmaceutical Biology

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Context: Primula denticulate Sm. (Primulaceae), commonly known as drumstick primula, is traditionally used to treat diabetes and urinary disorders. In the present study, a new triterpenoid saponin was isolated. Triterpenoids generally show antidiabetic activity. Considering its traditional use and chemical nature of the molecule, the present study was designed to evaluate the antidiabetic activity. Objective: Antidiabetic activity of triterpenoid saponin (TTS) isolated from P. denticulate. Materials and methods: A new TTS was isolated from the leaf of P. denticulate by column chromatography on CHCl 3 /MeOH (8.5:1.5) fraction. It was further characterized by using NMR, UV, and IR spectroscopic methods. Ethanol and aqueous extracts of the leaf were also prepared. Antidiabetic study for TTS, ethanol extract, and aqueous extract was carried out in streptozotocin (STZ)-induced diabetic rats at doses of 200, 1000, and 1000 mg/kg body weight, respectively. A toxicity study was also performed. -hydroxy-13b,28-epoxy-olean-30-al by NMR, UV, and IR spectroscopic methods. This new TTS was found to be effective in lowering blood-glucose level in the experimental rat model, thus establishing its antidiabetic property (168.8 AE 4.58) when compared with disease control (258.8 AE 0.60). Its LD 50 value was found at a dose of 2000 mg/kg. The level of insulin was restored by TTS and ethanol extract up to 31.49 mU/ml and 38.90 mU/ml, respectively, when compared with disease control (18.45 mU/ml). Discussion and conclusion: Results: Isolated new TTS molecule was characterized as 3-arabinopyranosyloxy]-16a-hydroxy-3b,28-epoxy-olean-30-al possesses potential glucose lowering properties, i.e., antidiabetic potential against STZ-induced diabetic rats.

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supporting

confidence: 52%

Antidiabetic potential of triterpenoid saponin isolated fromPrimula denticulate

Singh

Farswan²,

Ali³

et al. 2014

Pharmaceutical Biology

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“…Methanolic leaf and fruit extracts of Lantana camara were reported to possess antihyperglycemic property in both streptozotocin-and alloxan-induced diabetic rats (Ganesh et al, 2010;Kazmi et al, 2012;Venkatachalam et al, 2011). However, α-amylase inhibition property of L. camara is yet to be investigated.…”

Section: Sirmentioning

confidence: 99%

Phytochemical profile and <i>in vitro</i> α-amylase inhibitory potential of different solvent extracts of <i>Lantana camara</i>

Swamy

Sinniah

2015

Bangladesh J Pharmacol

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“…They are well known for their hepatoprotective effects against both acute chemically induced liver injury and chronic liver fibrosis and cirrhosis [1]. Moreover, a variety of novel pharmacological effects produced by these triterpenoids have been reported, such as antioxidant [2,3], anti-inflammatory [4,5], antitumour [6,7], anti-HIV [8], antimicrobial [9,10], gastroprotective [11] and the antiobese potential [12,13]. Given their occurrence at low levels in many herbal medicines and very low UV absorptions, the determination of OA and UA has attracted increasing attentions in research of traditional Chinese medicinal herbs (CMHs).…”

Section: Introductionmentioning

confidence: 99%

Utilization of Dispersive Liquid-Liquid Microextraction Coupled with HPLC-UV as a Sensitive and Efficient Method for the Extraction and Determination of Oleanolic Acid and Ursolic Acid in Chinese Medicinal Herbs

Hao¹,

Chen²,

Hu³

et al. 2012

AJAC

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Isomeric triterpenic acids of oleanolic acid (OA) and ursolic acid (UA) both have very low ultraviolet absorption and always exist in the same plant, so the separation and simultaneous determination of them have been a difficult task. In this study, a sensitive method combining dispersive liquid-liquid microextraction (DLLME) with HPLC-UV was developed for the extraction and determination of OA and UA in traditional Chinese medicinal herbs (CMHs). Variables influencing DLLME such as type and volume of extraction solvent, volume of dispersive solvent, ionic strength, aqueous phase pH, extraction time, centrifugation speed and time, and sample volume were investigated and optimized. Under the optimum conditions, both OA and UA attained favorable extraction efficiencies with enrichment factors 1378 and 933, respectively. The linear dynamic ranges of 0.07 -30.4 μg·mL -1 for OA and 0.08 -33.6 μg·mL -1 for UA were obtained with square correlation coefficients of 0.9963. The detection limits of OA and UA were both 0.02 μg·mL -1 . The method recoveries ranged between 88.2% -116.2% for OA and 85.7% -108.2% for UA with the RSDs (n = 5) lower than 8.6%. The proposed method was successfully applied to concentrate and simultaneously determine these two triterpenic acids in Hedyotis diffusa and Eriobotrya japonica samples.

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Anti-diabetic potential of ursolic acid stearoyl glucoside: A new triterpenic gycosidic ester from Lantana camara

Cited by 71 publications

References 32 publications

Antidiabetic potential of triterpenoid saponin isolated fromPrimula denticulate

Antidiabetic potential of triterpenoid saponin isolated fromPrimula denticulate

Phytochemical profile and <i>in vitro</i> α-amylase inhibitory potential of different solvent extracts of <i>Lantana camara</i>

Utilization of Dispersive Liquid-Liquid Microextraction Coupled with HPLC-UV as a Sensitive and Efficient Method for the Extraction and Determination of Oleanolic Acid and Ursolic Acid in Chinese Medicinal Herbs

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