Anti-diabetic potential of Barleria lupulina extract in rats

Suba, V.; Murugesan, T.; Arunachalam, G.; Mandal, Subhash C.; Saha, B. P.

doi:10.1078/0944-7113-00316

Cited by 66 publications

(49 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Herbal drugs are prescribed widely because of their effectiveness, less side effects and relatively low cost (Venkatesh et al, 2003). Therefore, investigation on such agents from traditional medicinal plants has become more important (Suba et al, 2004a). India has a rich history of using various potent herbs and herbal components for treating diabetes.…”

Section: Introductionmentioning

confidence: 99%

Leads from Indian medicinal plants with hypoglycemic potentials

Mukherjee

Maiti

Mukherjee

et al. 2006

Journal of Ethnopharmacology

392

214

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Leads from Indian medicinal plants with hypoglycemic potentials

Mukherjee

Maiti

Mukherjee

et al. 2006

Journal of Ethnopharmacology

392

214

View full text Add to dashboard Cite

“…Herbal drugs are prescribed widely because of their effectiveness, less side effects, and relatively low cost (Venkatesh et al, 2003). Therefore, investigation on such agents from traditional medicinal plants has become more important (Suba et al, 2004). A detailed study of such known medicinal plants and search for active molecules might offer natural key to unlock a diabetologist's pharmacy for the future.…”

Section: Introductionmentioning

confidence: 99%

Acacia catechu hard wood: potential anti-diabetic cum anti-dyslipidemic

et al. 2010

View full text Add to dashboard Cite

The ethanolic as well as aqueous extracts of the hard wood of Acacia catechu showed improvement on oral glucose tolerance post-sucrose load in normal rats and streptozotocin (STZ)-induced diabetic rats. Around 22 and 27% improvement in glucose tolerance was observed post 7 and 14 days of feeding the ethanolic extracts, respectively, on STZ-induced diabetic rats. Whereas around 17 and 26% improvement on glucose tolerance was observed post 7 and 14 days of feeding the ethanolic extract in the high fructose high fat diet (HFD) fed-low dosed STZ-treated rats. The ethanolic extract of A. catechu hard wood also showed marked anti-dyslipidemic activity on HFD fed Syrian golden hamster as evidenced by around 43 and 26% decline in serum triglycerides and total cholesterol, respectively. The ethanolic and aqueous extracts also showed marked inhibition on eye lens aldose reductase either from normal or STZ-induced diabetic rats. Further studies are warranted to isolate and identify the active ingredients from the ethanolic and aqueous extracts of A. catechu hard wood.Keywords Acacia catechu (A. catechu) hard wood Á Streptozotocin (STZ) induced diabetic rats Á High fructose high fat diet (HFD) diabetic rats Á Type 2 diabetes mellitus (T2DM) Á Dyslipidemia Á Aldose reductase (AR)

show abstract

“…3 Moreover, they are not safe in pregnancy hence the search for safer and more effective hypoglycemic agents has continued. 4 Several investigations have been conducted and many plants have shown a positive activity.…”

Section: Medicinal Herbsmentioning

confidence: 99%

A study of hypoglycemic effect of Caesalpinia bonduc extract on alloxan induced diabetic albino rats

Nadaf¹

2017

Int J Basic Clin Pharmacol

View full text Add to dashboard Cite

Background: The objective of the study was to scientifically investigate the oral hypoglycemic activity of Caesalpinia bonduc on Alloxan induced diabetic albino rats. To compare the hypoglycemic effect of Caesalpinia bonduc with that of the standard drug Glibenclamide used in the treatment of diabetes mellitus.Methods: Adult healthy albino rats of wister strain of either sex weighing 150-200gms were included in the study. The animals were divided into 4 groups namely control, diabetic control, standard and test groups with 6 animals in each group. Diabetes was chemically induced using alloxan to produce hyperglycemia in rats. Standard drug Glibenclamide suspended in gum acacia was administered for standard group. Test drug Caesalpinia bonduc was administered for test group. Morning around 9 a.m. blood glucose levels were recorded on 1st, 3rd, 7th, 14th, 21st, and 28th days.Results: The control group of rats showed no variation. The diabetic control rats showed consistent hyperglycemia. Comparing the test drug Caesalpinia bonduc to the standard drug Glibenclamide, the test drug was 1.38 times more efficacious than the standard.Conclusions: The alcoholic extract of Caesalpinia bonduc (seeds) has shown more anti diabetic activity by lowering the blood glucose levels in diabetic rats significantly. These findings suggest that hypoglycemic potential of the test compound Caesalpinia bonduc is promising and found to be more significant than the standard compound.

show abstract

Anti-diabetic potential of Barleria lupulina extract in rats

Cited by 66 publications

References 14 publications

Leads from Indian medicinal plants with hypoglycemic potentials

Leads from Indian medicinal plants with hypoglycemic potentials

Acacia catechu hard wood: potential anti-diabetic cum anti-dyslipidemic

A study of hypoglycemic effect of Caesalpinia bonduc extract on alloxan induced diabetic albino rats

Contact Info

Product

Resources

About