Anti-diabetic functional food with wasted litchi seed and standard of quality control

Choi, S. S.; Lee, Ji Eun; Kyung, Min Ji; Youn, Ju Hee; Oh, Jeong Bin; Whang, Wan Kyunn

doi:10.1007/s13765-017-0269-9

Cited by 23 publications

(8 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is an A-type dimeric form of procyanidin. The high inhibitory activity of procyanidin A2 was previously attributed to the unsaturated C ring, 3-OH, and hydroxyl substitutions on the B ring (Choi et al 2017 ). Interestingly, the oral administration of structurally similar procyanidins did not inhibit intestinal α-glucosidase activity in vivo (Yamashita et al 2016 ).…”

Section: Plant Secondary Metabolites As Alpha-glucosidase Inhibitorsmentioning

confidence: 96%

A review of alpha-glucosidase inhibitors from plants as potential candidates for the treatment of type-2 diabetes

et al. 2021

View full text Add to dashboard Cite

Diabetes mellitus is a multifactorial global health disorder that is rising at an alarming rate. Cardiovascular diseases, kidney damage and neuropathy are the main cause of high mortality rates among individuals with diabetes. One effective therapeutic approach for controlling hyperglycemia associated with type-2 diabetes is to target alpha-amylase and alpha-glucosidase, enzymes that catalyzes starch hydrolysis in the intestine. At present, approved inhibitors for these enzymes are restricted to acarbose, miglitol and voglibose. Although these inhibitors retard glucose absorption, undesirable gastrointestinal side effects impede their application. Therefore, research efforts continue to seek novel inhibitors with improved efficacy and minimal side effects. Natural products of plant origin have been a valuable source of therapeutic agents with lesser toxicity and side effects. The anti-diabetic potential through alpha-glucosidase inhibition of plant-derived molecules are summarized in this review. Eight molecules (Taxumariene F, Akebonoic acid, Morusin, Rhaponticin, Procyanidin A2, Alaternin, Mulberrofuran K and Psoralidin) were selected as promising drug candidates and their pharmacokinetic properties and toxicity were discussed where available. Supplementary Information The online version contains supplementary material available at 10.1007/s11101-021-09773-1.

show abstract

Section: Plant Secondary Metabolites As Alpha-glucosidase Inhibitorsmentioning

confidence: 96%

A review of alpha-glucosidase inhibitors from plants as potential candidates for the treatment of type-2 diabetes

et al. 2021

View full text Add to dashboard Cite

show abstract

“…With the continuous optimization of the lychee seed extraction process, a number of monomers have been successfully identified and isolated. Here, several single isolated compounds including (2R)naringenin-7-O-(3-O-αL-rhamnopyranosylβ-D-glucopyranoside) (Ren et al, 2011), (2S)-Pinocembrin-7-O-(6-O-a-L-rhamnopyranosyl-β-D-glucopyranoside) (Ren et al, 2011), quercetin (Ren et al, 2013), procyanidin A1 (Xiong et al, 2020), procyanidin A2 (Choi et al, 2017), and phlorhizin (Ren et al, 2013) exhibiting potential beneficial effects on regulating glycemia are prominently described in Table 2.…”

Section: Potential Bioactive Compounds Of Lychee Seed Responsible For Hypoglycemic Activitiesmentioning

confidence: 99%

Lychee Seed as a Potential Hypoglycemic Agent, and Exploration of its Underlying Mechanisms

Zhang

Jin

et al. 2021

Front. Pharmacol.

View full text Add to dashboard Cite

Food is people’s primal want. A reasonable diet and healthy food not only provide nutrients for human growth but also contribute to disease prevention and treatment, while following an unhealthy diet can lead to an increased risk of many diseases, especially metabolic disorders, such as diabetes. Nature is enriched with different food sources, and it seems that purely natural products are more in line with the current concept of health, which enhance the formation of the notion that “Food/Diet Supplements from Natural Sources as a Medicine.” As a delicious fruit, the medicinal values such as anticancer, antibacterial, antioxidation, and antiglycating properties of lychee have been found. Lychee (Litchi in Chinese) is a subtropical fruit plant belonging to the family Sapindaceae. It has been widely cultivated in warm climates worldwide, particularly in China, for thousands of years. In recent years, various phytochemical components such as quercetin, procyanidin A2, and (2R)-naringenin-7-O-(3-O-αL-rhamnopyranosyl-β-D-glucopyranoside) have been identified in a lychee seed, which may lend a lychee seed as a relatively safe and inexpensive adjuvant treatment for diabetes and diabetic complications. In fact, accumulating evidence has shown that lychee seed, lychee seed extracts, and related compounds have promising antihyperglycemic activities, including improving insulin resistance, anti-inflammatory effect, lipid regulation, neuroprotection, antineurotoxic effect, and renoprotection effect. In this review, we summarized publications on antiglycemic effects and mechanisms of lychee seed, lychee seed extracts, and related compounds, which included their efficacies as a cure for diabetes and diabetic complications in cells, animals, and humans, attempting to obtain a robust evidence basis for the clinical application and value of lychee seed.

show abstract

“…In addition to anti-cancer activity, Chen et al (2017) found a hepatoprotective activity of litchi procyanidin A2 against carbon tetrachloride-induced liver injury in ICR mice. Recently, Choi et al (2017) reported that litchi seeds could be a cost-effective medicinal food agent in terms of recyclable resources and might act as a natural alternative medicine against type-2 diabetes.…”

Section: Pharmacological Activitymentioning

confidence: 99%

Pericarp and seed of litchi and longan fruits: constituent, extraction, bioactive activity, and potential utilization

Zhu

Wang

Jian

et al. 2019

J. Zhejiang Univ. Sci. B

View full text Add to dashboard Cite

Litchi (Litchi chinensis Sonn.) and longan (Dimocarpus longan Lour.) fruits have a succulent and white aril with a brown seed and are becoming popular worldwide. The two fruits have been used in traditional Chinese medicine as popular herbs in the treatment of neural pain, swelling, and cardiovascular disease. The pericarp and seed portions as the by-products of litchi and longan fruits are estimated to be approximately 30% of the dry weight of the whole fruit and are rich in bioactive constituents. In the recent years, many biological activities, such as tyrosinase inhibitory, antioxidant, anti-inflammatory, immunomodulatory, anti-glycated, and anti-cancer activities, as well as memory-increasing effects, have been reported for the litchi and longan pericarp and seed extracts, indicating a potentially significant contribution to human health. With the increasing production of litchi and longan fruits, enhanced utilization of the two fruit by-products for their inherent bioactive constituents in relation to pharmacological effects is urgently needed. This paper reviews the current advances in the extraction, processing, identification, and biological and pharmacological activities of constituents from litchi and longan by-products. Potential utilization of litchi and longan pericarps and seeds in relation to further research is also discussed.

show abstract

Anti-diabetic functional food with wasted litchi seed and standard of quality control

Cited by 23 publications

References 22 publications

A review of alpha-glucosidase inhibitors from plants as potential candidates for the treatment of type-2 diabetes

A review of alpha-glucosidase inhibitors from plants as potential candidates for the treatment of type-2 diabetes

Lychee Seed as a Potential Hypoglycemic Agent, and Exploration of its Underlying Mechanisms

Pericarp and seed of litchi and longan fruits: constituent, extraction, bioactive activity, and potential utilization

Contact Info

Product

Resources

About