Anti‐diabetic effects of resveratrol

Szkudelski, Tomasz; Szkudelska, Katarzyna

doi:10.1111/j.1749-6632.2010.05844.x

Cited by 212 publications

(134 citation statements)

References 48 publications

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“…However, more recent studies on the role of SIRT1 in the mechanism of RSV action suggest that its action should be reconsidered, since they have shown that RSV is not a direct activator of Sirt1 [44]. Although the exact mechanisms of RSV action are still unclear, there is no doubt that this compound is able to improve insulin action in different animal models of insulin resistance [45][46].…”

Section: Abbreviationsmentioning

confidence: 99%

Resveratrol and Diabetes

Vallianou¹,

Evangelopoulos²,

Kazazis³

2013

Rev Diabet Stud

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■ AbstractResveratrol is a stilbene compound, and a phytoalexin, synthesized by plants in response to stressful stimuli, usually caused by infection. It is abundantly present in red wine, ports and sherries, red grapes, blueberries, peanuts, itadori tea, as well as hops, pistachios, and in grape and cranberry juices. The anti-hyperglycemic effects of resveratrol seem to be the result of an increased action of the glucose transporter in the cytoplasmic membrane. Studies on rats with streptozotocin-induced diabetes have demonstrated that the expression of the insulin-dependent glucose transporter, GLUT4, is increased after resveratrol ingestion. Also, resveratrol enhances adiponectin levels, which could be one of the potential mechanisms by which it improves insulin sensitivity. Another important observation is that resveratrol induces the secretion of the gut incretin hormone, glucagonlike peptide-1. Resveratrol is also reported to activate Sir2 (silent information regulatory 2), a SIRT1 homolog, thus mimicking the benefits of calorie restriction. It produces a wide variety of effects in mammalian cells, including activation of AMP-activated protein kinase, which is involved in some of the same metabolic pathways as SIRT1, which may influence other mechanisms via the involvement of nuclear factor kappa B (NF-κB). In the near future, resveratrol-based therapies with either resveratrol or its analogs that have better bioavailability could be useful in the treatment of diabetes and its complications, either alone or in combination with other anti-diabetic drugs.

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Section: Abbreviationsmentioning

confidence: 99%

Resveratrol and Diabetes

Vallianou¹,

Evangelopoulos²,

Kazazis³

2013

Rev Diabet Stud

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“…Plant-food polyphenols have been shown to attenuate hepatic gluconeogenesis via decreasing the activity of glucose-6-phosphatase and phosphoendolpyruvate carboxykinase (PEPCK) and down regulation of liver glucokinase expression (Waltner-Law et al, 2002). Several studies have shown that polyphenol compounds protect β-cells from oxidative-induced damages by enhancing the natural antioxidant system, inhibition of lipid peroxidation and stimulation on the β-cells (Szkudelski, 2007;Szkudelski and Szkudelska, 2011) . These suggest that the possible mechanisms for antidiabetic action of ISWF may be due to stimulation of peripheral glucose uptake in tissues, modulation of carbohydrate metabolism and attenuation of intestinal absorption for dietary carbohydrate.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of hypoglycemic and hypolipidemic effects of internal septum of walnut fruit in alloxan-induced diabetic rats

Ghiravani¹,

Hosseini²,

Taheri³

et al. 2016

Afr. J. Trad. Compl. Alt. Med.

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Background: Todays, the popularity of herbal medicine is increasing worldwide. Due to importance the evaluation of medicinal herbs efficacy and safety, the present study was conducted to investigate the antidiabetic and hypolipidemic effects of internal septum of walnut fruit (ISWF) ethanolic extract in diabetic rats. Materials and methods: Alloxan diabetic rats treated orally with ethanolic extract of ISWF (0-400mg/kg) for 28 days. To evaluate its anti-diabetic activity, the animals fasting blood glucose were determined on the first, 14 th and 29 th days. Moreover, oral glucose tolerance test (OGTT) was performed in diabetic rats at the last day of the study. After 24h of last administration, the blood samples were collected, and the Plasma lipids and liver enzymes levels were measured in fasting overnight rats. Results: The extract significantly decreased blood glucose (p<0.001) on 14 th and 29 th days. In addition, OGTT revealed that the hypoglycemic effect of the extract appeared at 90 minutes. Alanine aminotransferase and aspartate aminotransferase levels significantly decreased in diabetic rats treated with the both doses (p<0.05). Both doses of the extract were able to decrease triglyceride significantly (p<0.05) in treated diabetic rats, while only the lower dose of the extract (200 mg/kg) attenuate the total cholesterol and low density lipoprotein (p<0.001). Conclusion: These finding support the notion that ISWF is able to reduce hyperglycemia and hyperlipidemia risk in diabetic rats. Key words:Juglans regia, internal septum, walnut fruit, Antidiabetic, Lipid profile IntroductionDiabetes mellitus is a chronic metabolic disease characterized by hyperglycemia due to the impaired secretion and/or action of insulin (Chikhi et al., 2014). Its prevalence is increasing in many populations all over the world. In 2011, there were 366 million cases with diabetes, and it is expected to increase up to 522 million by 2030(Whiting et al., 2011. Hyperglycemia leads to alteration in metabolism of carbohydrate, protein and fat (Wan et al., 2013). This condition results in long term pathogenic disorders such as neuropathy, retinopathy and nephropathy and consequently lowering in life quality (Santaguida et al., 2005). Currently, multiple pharmacological interventions including sulphonylureas, biguanides, alpha-glucosidase inhibitors, thiazolidinediones and/or insulin are applied for the treatment of diabetes (Grossman et al., 2013). However, all of these medications have limited efficacy and result in various side effects such as gastrointestinal upset, weight changes, hypoglycemia, joint stiffness, kidney and skin complications (Nathan, 2007;Soccio et al., 2014).Complementary and alternative medicine has been often used for treatment of diabetes. The most widely used therapies in diabetic populations are nutritional supplements and herbal; people with diabetes use these therapies concurrently with conventional health care services (Chang et al., 2007).The fruit of Juglans regia L (family; Juglandaceae) is a valu...

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“…Resveratrol shields against hepatic and renal impairment in the diabetic patients [29]. This indicates that resveratrol has beneficial role in the prevention and treatment of diabetes [28].…”

Section: Resveratrol In Diabetesmentioning

confidence: 97%

“…It has experimentally proved that resveratrol lowers the insulin secretion in blood. Its inhibitory effect has been proved in hyperinsulinemic animals [28]. Resveratrol shields against hepatic and renal impairment in the diabetic patients [29].…”

Section: Resveratrol In Diabetesmentioning

confidence: 99%