Anti-Diabetic Effects of Phenolic Extract from Rambutan Peels (Nephelium lappaceum) in High-Fat Diet and Streptozotocin-Induced Diabetic Mice

Abstract

Recent studies have shown that rambutan peel phenolic (RPP) extract demonstrate high antioxidant and antiglycation activities in vitro and in vivo. This study further evaluated the anti-diabetic activity of RPP in a mouse model of Type II diabetes induced by streptozotocin combined with high-fat diet. Results showed that RPP increased the body weight and reduced the fasting blood glucose level of the diabetic mice. RPP significantly reduced the serum levels of total cholesterol, triglyceride, creatinine, and glycated serum protein in diabetic mice in a dose-dependent manner. Glycogen content in mice liver was recovered by RPP, which further increased the activity of superoxide dismutase and glutathione peroxidase and reduced lipid peroxidation in diabetic mice. Histological analysis showed that RPP effectively protected the tissue structure of the liver, kidney, and pancreas. In addition, RPP decreased the mesangial index and inhibited the expression of TGF-β in the kidney of diabetic mice.

Phytochemical Analysis and hypoglycemic potential of Filago hurdwarica (Wall. ex DC.) Wagenitz in alloxan induced diabetic mice

“…However, treatments with orally administered methanolic, and chloroform extracts of 250 mg/kg significantly improved the body weight compared with diabetic control which signifies its protective effect in controlling muscle wasting i.e. reversal of gluconeogenesis, and subduing the free radicals produced due to hyperglycemia (Ma et al, 2017;Mestry et al, 2016).…”

Microencapsulation of Rambutan Peel Extract by Spray Drying

“…Different researchers have studied the effect of the consumption of the rambutan peel extract on health, determining that this could be an important factor for the prevention of several diseases. In this sense, beneficial properties such as anti-inflammatory, antidiabetic, antioxidants, antiaging, antiobesity, antimicrobial, anti-osteoporosis, photoprotective, and anticancer have been reported for rambutan peel extract [6,[11][12][13][14][15][16][17][18].…”

Review of Nephelium lappaceum and Nephelium ramboutan-ake: A High Potential Supplement

“…Moreover, rats treated with N. lappaceum extract showed signs of anti-hyperglycemia such as reduction in blood glucose level and improvement of glucose tolerance. Organ damage such as to the liver, pancreas and kidney was not observed in diabetic rats treated with N. lappaceum peel extract [60,61]. This result is supported by a study where rats that were orally administered geraniin from the peel did not show significant adverse results in body weight and organ, even though higher feed was taken by the rat [62].…”

“…The hypoglycemic actions of N. lappaceum were studied in vivo, in which the reduction in α-glucosidase and α-amylase enzyme activities were observed [60,61]. Moreover, rats treated with N. lappaceum extract showed signs of anti-hyperglycemia such as reduction in blood glucose level and improvement of glucose tolerance.…”