Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice

Kim, Sung Hee; Hyun, Sun Hee; Choung, Se‐Young

doi:10.1016/j.jep.2005.08.059

Cited by 395 publications

(261 citation statements)

References 15 publications

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“…Il est démontré par plusieurs travaux que ces métabolites secondaires seraient doués de cette activité (Guerci et al 2001 ;Kebieche, 2009). Les flavonoïdes sont doués des propriétés hypoglycémiantes et antidiabétiques suivant les résultats de plusieurs travaux réalisés (Guerci et al 2001 ;Huang et al 2004 ;Raccah, 2004 ;Punitha et al 2006 ;Kim et al 2006 ;Kebieche, 2009). Plusieurs mécanismes sont attribués aux flavonoïdes pour cette activité.…”

Section: Résuméunclassified

“…Dans une espèce très voisine de Salvia officinalis, en occurrence la sauge clarée, les tanins, saponines, glucides, alcools aromatiques et bien d'autres, ont été reconnus. Selon une étude, l'effet hypoglycémiant significatif et durable total acétonique pourrait bien être lié à la présence à la fois des composées de types flavonoïdes et alcaloïdes agissant probablement de façon synergique (Kim et al, 2006 ;Sy et al, 2008). Cette étude est réalisée dans la perspective …”

Section: Résuméunclassified

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Contribution à l’étude photochimique de quelques plantes médicinales antidiabétiques de la ville de Bukavu et ses environs (Sud-Kivu, R.D.Congo).

Mangambu¹,

Mushagalusa²,

Kadima³

2014

J. App. Bioscience.

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Section: Résuméunclassified

Contribution à l’étude photochimique de quelques plantes médicinales antidiabétiques de la ville de Bukavu et ses environs (Sud-Kivu, R.D.Congo).

Mangambu¹,

Mushagalusa²,

Kadima³

2014

J. App. Bioscience.

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“…Kim et al (6) was the first to suggest that cinnamon may act by stimulating endogenous insulin production. If this were true, it would explain our result.…”

Section: Statistical Analysesmentioning

confidence: 99%

“…Using a rat model, Qin et al (5) (2) observed that when cinnamon and insulin were combined in vitro, the effect was greater than was expected, implying a synergistic relationship. Additionally, Kim et al (6) proposed that cinnamon acts by increasing endogenous insulin production, rather than by a target-based mechanism.…”

mentioning

confidence: 99%

The Effect of Cinnamon on A1C Among Adolescents With Type 1 Diabetes

et al. 2007

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OBJECTIVE -The purpose of this study was to determine the effect of cinnamon on glycemic control in adolescents with type 1 diabetes.RESEARCH DESIGN AND METHODS -Using a prospective, double-blind, placebocontrolled design, 72 adolescent type 1 diabetic subjects were treated in an outpatient setting with cinnamon (1 g/day) or an equivalent-appearing placebo for 90 days. A1C, total daily insulin intake, and adverse events were recorded and compared between groups.RESULTS -There were no significant differences in final A1C (8.8 vs. 8.7, P ϭ 0.88), change in A1C (0.3 vs. 0.0, P ϭ 0.13), total daily insulin intake, or number of hypoglycemic episodes between the cinnamon and placebo arms.CONCLUSIONS -Cinnamon is not effective for improving glycemic control in adolescents with type 1 diabetes. Diabetes Care 30:813-816, 2007

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“…Diabetes mellitus is a chronic hyperglycemic disorder associated with disruption in carbohydrate, fat and protein metabolisms emanating from deficiencies or disruptions in insulin secretion, defects in reactive oxygen species scavenging enzymes, and high oxidative stress impairing pancreatic beta cells (Kim et al, 2006). The classical symptoms of diabetes are weight loss, polyuria (increased urination), polydipsia and polyphagia (Das et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Haematological changes and wound healing effects of sildenafil citrate in diabetic albino rats

Mahre¹,

Umaru²,

Ngulde³

et al. 2017

Sokoto J. Vet. Sc.

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This study presents baseline data on the effect of sildenafil citrate on some of the haematological and biochemical parameters in wistar rats with diabetes and wound formation. Forty two albino rats weighing between 139 and 225 g were separated at random into seven groups (A, B, C, D, E, F and G) of six rats per group. Type 1 diabetes mellitus was induced in groups A, B, C and D by a single intra-peritoneal injection of 130 mg/kg Alloxan. Rats in group A were treated with orally dose of 50 mg/kg sildenafil citrate for 21 days and rats in group B were administered 10 IU of insulin intramuscularly once and sildenafil citrate as in Group A. The rats in group C were treated with a single dose of 10 IU of insulin intramuscularly, and rats in group D with only distilled water. Groups E and F were normal rats with wounds similar to those of diabetic rats in the previous groups and each rat in group E was also treated with sildenafil citrate as in Group A and those in group F were treated with only distilled water. Group G were normal rats without wound treated with sildenafil citrate as in Group A. Blood samples were taken before (day 0) and after the administration of the sildenafil citrate on day 7, 14 and 21. The results of the study showed significant decreased in red blood cells count from 6.28 ± 0.46 × 10 6 to 2.81 ± 0.46 × 10 6 in diabetic rats during the 14 days of treatment with sildenafil citrate, however, there was an indication that continues treatment for up to 21 days reduced the blood glucose and increased the red blood cells count and this may be an indication that sildenafil citrate improves insulin mediated glucose pathways.

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Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice

Cited by 395 publications

References 15 publications

Contribution à l’étude photochimique de quelques plantes médicinales antidiabétiques de la ville de Bukavu et ses environs (Sud-Kivu, R.D.Congo).

Contribution à l’étude photochimique de quelques plantes médicinales antidiabétiques de la ville de Bukavu et ses environs (Sud-Kivu, R.D.Congo).

The Effect of Cinnamon on A1C Among Adolescents With Type 1 Diabetes

Haematological changes and wound healing effects of sildenafil citrate in diabetic albino rats

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