Anti-diabetic effect of camel milk in alloxan-induced diabetic dogs: a dose-response experiment

Abstract

This study was conducted to evaluate the effect of camel milk in alloxan-induced diabetic dogs and to follow this effect at three doses of milk. Firstly, three groups of dogs were used: two groups composed each of four diabetic dogs and receiving raw camel milk (treatment 1) or cow milk (treatment 2), and four healthy dogs getting raw camel milk (treatment 3) were used as control. Each animal was treated with 500 ml of milk daily. Secondly, we compared the effects of three amounts of camel milk: 100 ml, 250 ml and 500 ml to treat the diabetic dogs. After week 3, the dogs treated with camel milk showed a statistically significant decrease in blood glucose (from 10.88 +/- 0.55 to 6.22 +/- 0.5 mmol/l) and total protein concentrations (from 78.16 +/- 2.61 g/l to 63.63 +/- 4.43 g/l). For cholesterol levels, there was a decrease from week 2 (from 6.17 +/- 0.5 mmol/l to 4.79 +/- 0.5 mmol/l). There were no significant difference in blood glucose, cholesterol or total protein concentrations in dogs drinking 250 and 500 ml of camel milk. The dogs treated with 100 ml of camel milk did not show any significant decrease in blood glucose levels, and cholesterol and total protein concentrations. The investigation was not limited to the improvement in glycemic balance, lipids and proteins control in diabetic dogs getting camel milk, but we also noted a stability of this state after the dogs stopped to drink milk. This effect depended on the quantity of camel milk used to treat diabetic dogs.

Camel milk ameliorates the coagulopathy in streptozotocin diabetic rat model

“…; Sboui et al . ), and the findings of the present study are in agreement. We have shown that the administration of CM to STZ‐induced diabetic rats resulted in significant correction of the blood glucose and also improved the circulating levels of insulin.…”

“…; Sboui et al . ). For example, camel breeders in India who consume CM regularly have zero incidence of DM, as compared to 5.5% in other communities in which CM is not consumed (Agrawal et al .…”

Through the eye of an electrospray needle: mass spectrometric identification of the major peptides and proteins in the milk of the one‐humped camel (Camelus dromedarius)

“…Reports also claim that camel milk can cure severe food allergies in children unresponsive to more conventional treatments and aid in the management of diabetes and its complications . For example, in a dog model of alloxan‐induced diabetes, 3‐week consumption of camel milk resulted in a statistically significant decrease in blood glucose, total protein and cholesterol . Efficacy was dose‐related and glycemic control persisted for 2 weeks after the dogs stopped drinking camel milk.…”

Camel Milk: An Important Natural Adjuvant

“…The presence of high concentration of insulin/insulin-like substances in camel milk such as half-cystine [15], the effect of small-sized immunoglobulins of camel milk on bcell [7] and the lack of coagulation of camel milk in the human stomach contribute to the hypoglycemic effect in type 1 diabetes in human [6], rats [99] as well as in alloxaninduced diabetic dogs [102].…”