Anti-Diabetic, Anti-Oxidant and Anti-Hyperlipidemic Activities of Flavonoids from Corn Silk on STZ-Induced Diabetic Mice

Abstract

Abstract:Corn silk is a well-known ingredient frequently used in traditional Chinese herbal medicines. This study was designed to evaluate the anti-diabetic, anti-oxidant and anti-hyperlipidemic activities of crude flavonoids extracted from corn silk (CSFs) on streptozotocin (STZ)-induced diabetic mice. The results revealed that treatment with 300 mg/kg or 500 mg/kg of CSFs significantly reduced the body weight loss, water consumption, and especially the blood glucose (BG) concentration of diabetic mice, which indicated their potential anti-diabetic activities. Serum total superoxide dismutase (SOD) and malondialdehyde (MDA) assays were also performed to evaluate the anti-oxidant effects. Besides, several serum lipid values including total cholesterol (TC), triacylglycerol (TG), low density lipoprotein cholesterol (LDL-C) were reduced and the high density lipoprotein cholesterol level (HDL-C) was increased. The anti-diabetic, anti-oxidant and anti-hyperlipidemic effect of the CSFs suggest a potential therapeutic treatment for diabetic conditions.

Antidiabetic Effects of Pumpkin (Cucurbita Moschata Durch) Flesh and Seeds Extracts in Streptozotocin Induced Mice

“…The disease is characterized by the high levels of blood glucose due to the absence of insulin or insulin resistance [1][2][3]. In the present day, there is a global increase in the prevalence of DM which related to the lifestyle and obesity [4].…”

The Maize Contribution in the Human Health

“…However, it is necessary to conduct studies with in vivo models that support these findings [57]. Raw extracts of flavonoids contained in corn stigmata have been used in models of diabetic mice reporting a decrease in body weight, glycemia, and antidiabetic capacity, in addition to the reduction in the levels of total cholesterol, of triglycerides, of low-density lipoproteins and an increase in the levels of high-density lipoproteins, suggesting an anti-hyperlipidemic effect [58]. Therefore, corn is proposed as a nutraceutical food, with a potential therapeutic effect to improve the alterations associated with diabetes.…”

Plantas Medicinais Potencialmente Hipolipidêmicas

“…Entretanto, as limitações que existem no uso destes medicamentos, assim como os efeitos colaterais, tais como insuficiência hepática e renal, diarreia, hipoglicemia, fazem estes medicamentos intoleráveis para alguns pacientes que necessitam administrá-los. Desta forma, a busca por novas alternativa que visam encontrar novos compostos que aumentem a eficácia e também diminuam a sua toxicidade, evolui cada vez mais, incentivando no desenvolvimento de novas pesquisas que busquem alternativas em compostos naturais (ZANG et al, 2016).…”