Anti-diabetic and anti-oxidant potential of aged garlic extract (AGE) in streptozotocin-induced diabetic rats

Abstract

BackgroundAlthough aged garlic extract (AGE) shares some active components with fresh garlic and in spite of its palatability and milder side effects, the anti-diabetic and related anti-oxidant properties of AGE have not been investigated extensively, and the reported findings are inconsistent.This study investigated the anti-diabetic effects of 3 incremental doses of AGE in streptozotocin (STZ)-induced diabetic rats (fasting blood sugar > 20 mM).MethodDiabetic rats were divided into a control diabetic group (CD) and AGE-treated diabetic group (AGE-D). The AGE-D was divided into 3 groups and accordingly treated with AGE i.p. at 100, 300 and 600 mg/kg daily for 8 weeks. A control normal group (CN) was also included for reference.ResultsCompared to the CN group, the CD group showed significant loss of body weight (over 50 %); and decreased serum insulin concentration (10 fold) and total anti-oxidant level and catalase activity (45–70 %) in serum, kidney and liver. Conversely, the CD rats had an elevated blood glucose (nearly 4 fold), serum cholesterol (nearly 2 fold) and triglycerides (>2 fold), erythrocyte glycated hemoglobin (GHb, 3 fold) and kidney and liver lipid peroxidation (MDA levels). Treatment with AGE positively reversed the diabetic changes in the targeted parameters to levels significantly lower than those measured in the CD group and the degrees of attenuation were almost dose dependent especially with the two higher doses.ConclusionAGE exhibits a dose-dependent ameliorative action on indicators of diabetes in STZ-induced diabetic rats.

To study the anti-hypertensive and lipid-lowering effects of garlic as add-on therapy to amlodipine in patients of hypertension with obesity

“…34 Ajoene, a breakdown product of allicin, induce apoptosis, decrease lipid accumulation in adipocytes and increase thermogenesis. 34,35 Safety and tolerability Both AGE and amlodipine were well tolerated during the study and no new safety concerns were observed that were not known to occur with individual drug therapies. As shown in Table 3, total of four (13.3%) patients in group I and six (20%) patients in group II reported adverse drug reactions.…”

Bioadhesive Garlic and Ketoconazole Vaginal Tablets for Treatment of Candidiasis

“…8 Allium sativum L. (Liliaceae) commonly called garlic is used in modern folkloric medicine, as well as a spice for the treatment of many ailments. [9][10][11] Garlic, has been recognized to have a potential medicinal value due to its active constituents alliin (~0.8%) and allicin (∼3.7 mg/g) and is used as antifungal, antibacterial, antiviral, anti-helmintic, anti-inflammatory and antiseptic. 12 Moreover, reported literature indicates that garlic extracts exhibit activities against both gram negative and gram positive microbes all of which are cause of morbidity worldwide.…”

Traditional medicinal plants used for the treatment of diabetes in the Sudan: A review

“…Adminstration of queous extract of A. sativum to induced diabetic rats reduced the blood glucose level, total serum lipids and cholesterol (Thomson et al, 2007;Ozougwu and Eyo, 2010;Badole et al, 2013;Thomson et al,2016).…”