Anti-diabetic activity of β-glucans and their enzymatically hydrolyzed oligosaccharides from Agaricus blazei

Kim, Yea-Woon; Kim, Ki-Hoon; Choi, Hyunju; Lee, Dong‐Seok

doi:10.1007/s10529-005-2225-8

Cited by 163 publications

(99 citation statements)

References 9 publications

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“…The decline may also be due to the reduction in cholesterol absorption by the nondigestible polysaccharides such as β-(1→ 3) glucans and the interaction of cholesterol with bile acids, which reduces their reabsorption into the enterohepatic circulation and causes the liver to divert cholesterol to bile acid production, thus reducing the cholesterol concentration in the blood (CHEUNG, 1996). The hypocholesterolemic and hypoglycemic effects of betaglucans, which are present in fungi of the Agaricus genus, attested to in rats, suggests a protective action on the biochemical and metabolic parameters of the animals and consequently, in maintaining the body's homeostasis (KIM et al, 2005;MASCARO et al, 2014). Table 6.…”

Section: Resultsmentioning

confidence: 99%

Effect of agaricus blazei in the diet of broiler chickens on immunity, serum parameters and antioxidant activity

Fanhani

Murakami

Guerra

et al. 2016

SCA

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The effect of adding Agaricus blazei to the diet of broilers on immunity, serum parameters, and antioxidant activity was evaluated. A total of 840 1-day-old chicks were used, distributed among five levels of a completely randomized design (0.0, 0.05, 0.10, 0.15, and 0.20% A. blazei), with six replications and 28 birds per experimental unit. The weights of the thymus, spleen and cloacal bursa were not influenced (P > 0.05). Leukocytes, macrophages and nitric oxide were unaffected (P > 0.05), but at each supplementation level compared with the control, differences appeared in the percentages of eosinophils and macrophages (P < 0.05) at inclusion levels of 0.10, 0.15 and 0.20%. At 28 days, the antibody titer against Newcastle disease showed a quadratic response (P < 0.05) with supplementation, and from the estimated level of 0.08% the production of antibodies was stimulated; however, the same behavior was not observed (P > 0.05) at 42 days. Hypocholesterolemic effect was demonstrated (P < 0.05), but the serum triglyceride concentration was not affected (P > 0.05). The antioxidant activity of mushroom showed a positive linear effect (P < 0.05) on DPPH capture on day zero of meat cooling. The inclusion of A. blazei in the diet of broilers provided an immunostimulatory activity and hypocholesterolemic effect. Residual compounds with antioxidant activity were present in the meat, which may promote tissue protection of the animal in vivo, making possible the use of A. blazei as a natural additive. Key words: Cholesterol. Free radical. Immunoglobulins. Leukocytes. Mushroom. ResumoAvaliou-se o uso do Agaricus blazei na alimentação de frangos de corte sobre a imunidade, parâmetros séricos e a atividade antioxidante. Utilizou-se 840 pintos distribuídos em delineamento experimental inteiramente casualizado, cinco níveis (0,0; 0,05; 0,10; 0,15 e 0,20%) de Agaricus blazei, seis repetições e 28 aves por unidade experimental. O peso do timo, baço e bolsa cloacal não foi influenciado pelos tratamentos experimentais (P>0,05). Os leucócitos, macrófagos e o óxido nítrico não foram afetados pelos níveis de Agaricus blazei (P>0,05), no entanto a porcentagem de eosinófilo e de macrófagos diferenciaram-se (P<0,05) nos níveis de 0,10, 0,15 e 0,20% em relação ao controle. Aos 28 dias, os níveis de anticorpos contra a doença de Newcastle apresentaram resposta quadrática (P<0,05) à suplementação, e a partir do nível estimado de 0,08% estimulou-se a sua produção, contudo o mesmo

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Section: Resultsmentioning

confidence: 99%

Effect of agaricus blazei in the diet of broiler chickens on immunity, serum parameters and antioxidant activity

Fanhani

Murakami

Guerra

et al. 2016

SCA

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“…Another research has been reported that glycosides could stimulate insulin secretion as well. The polysaccharide compounds derived from algae extracts and Agaricus blazei enhanced the insulin secretion in vitro in the pancreatic β-cells (19,20). Oat bran-derived non-starch polysaccharides acted as an active ingredient decreasing the postprandial hyperglycemic response in humans with type 2 diabetes (39).…”

Section: Discussionmentioning

confidence: 99%

“…The germinated wheat leafs generally are called wheatgrass, in some European countries, USA and India, and consumed as a health food due to a rich source of soluble fibers, vitamins, antioxidants and minerals (18). In the present study, according to evidence that plantderived polysaccharides have stimulatory effects on the insulin response (19,20), we investigated the stimulatory effects of water soluble polysaccharide derived from TASP on insulin release from the pancreatic cells in vitro and in vivo. We also elucidated the involvement of the ATP-sensitive K + channel and Ca 2+ influx with TASP using the pancreatic cells and rat islets, which have been used for the study of insulin secretogogues.…”

Section: Introductionmentioning

confidence: 99%

Polysaccharide isolated from Triticum aestivum stimulates insulin release from pancreatic cells via the ATP-sensitive K+ channel

et al. 2012

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Abstract. Traditional natural plants have been used throughout the world for their antidiabetic effects. The aim of the present study was to investigate the stimulating activity of a polysaccharide extract derived from T. aestivum sprout (TASP) on insulin secretion in vitro using the RIN-5F pancreatic β-cell line and rat pancreatic islets. In these experiments, TASP (0.1 to 2 mg/ml) augmented glucose-stimulated insulin secretion in a dose-dependent manner in the presence of a stimulatory glucose concentration (16.7 mM), but not of a basal concentration (1.1 mM). Although TASP failed to enhance the high K + -induced insulin secretion, the insulinotropic effect of TASP was significantly inhibited by diazoxide, an opener of ATP-sensitive K + channel blocking insulin release. TASP potentiated the insulin secretion induced by other secretagogues, such as IBMX and tolbutamide. Moreover, glucose-derived blood insulin levels were significantly elevated by oral administration of TASP to mice, similarly to antidiabetic drugs. We also demonstrated that TASP significantly increased glucose-induced 45 Ca2+ uptake and proinsulin mRNA expression in rat islets. Overall, our results suggest that TASP has a stimulating effect on insulin secretion and production in pancreatic β-cells via K + channel closure and calcium influx. These results suggest that TASP may be useful as a candidate for the therapy of diabetes mellitus.

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“…Trabalhos têm relatado que o AbM apresenta atividade antibacteriana, como, por exemplo, na avaliação in vitro contra agentes patogênicos orais para humanos, tais como Streptococcus mutans (Lund et al, 2009), além de atividade antioxidante (Soares et al, 2009), antidiabética (Kim et al, 2005), forte atividade imunoestimulante (Yuminamochi et al, 2007), bem como efeitos antitumorais e anticâncer (Yu et al, 2009), entre outros.…”

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Efeito da extração de compostos fenólicos sobre a atividade antioxidante e antibacteriana in vitro de cogumelo-do-sol

et al. 2016

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RESUMO: O cogumelo-do-sol (Agaricus blazei Murril) é amplamente consumido, por conta de suas propriedades medicinais. Este estudo teve como objetivo determinar a atividade antioxidante e antibacteriana in vitro dos extratos de cogumelo do sol, mediante diferentes tempos e temperaturas de extração. As amostras foram analisadas quanto à composição centesimal, determinação do teor de fenólicos totais e atividade antioxidante e antibacteriana in vitro. Os resultados demonstram que esse tipo de cogumelo aparece como um agente antioxidante potencial, obtendo-se melhores resultados na temperatura de 70ºC durante 60 minutos de extração hidroetanólica. Esse extrato não aponta atividade antibacteriana para os micro-organismos em teste.

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Anti-diabetic activity of β-glucans and their enzymatically hydrolyzed oligosaccharides from Agaricus blazei

Cited by 163 publications

References 9 publications

Effect of agaricus blazei in the diet of broiler chickens on immunity, serum parameters and antioxidant activity

Effect of agaricus blazei in the diet of broiler chickens on immunity, serum parameters and antioxidant activity

Polysaccharide isolated from Triticum aestivum stimulates insulin release from pancreatic cells via the ATP-sensitive K+ channel

Efeito da extração de compostos fenólicos sobre a atividade antioxidante e antibacteriana in vitro de cogumelo-do-sol

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