Anti-Diabetic Activity of Ethanolic Extract of Elaeocarpus Serratus L. In Streptozotocin-Induced Diabetic Rats

Abstract

To investigate the anti-diabetic activity of Elaeocarpus serratus fruit in streptozotocin-induced (STZ) diabetic rats. The dose-dependent effects of 30days oral treatment with ethanol extracts of fruit (200 and 400 mg/kg) of E. serratus on body weight, blood glucose level, total protein, albumin, liver marker enzymes and carbohydrate metabolizing enzymes were evaluated in STZ-induced diabetic rats. Oral administration ethanolic extract of fruit of E. serratus showed significant restoration of the body weight and decrease in the blood glucose level, liver marker enzymes (ALT, AST ALP) and carbohydrate metabolizing enzymes were observed in diabetic rats. These results suggest that fruit extract of E. serratus has valuable anti-diabetic activity in STZ-induced diabetic rats which is comparable to the standard drug glibenclamide and hence might be of use in the management of diabetes.

Antimicrobial Activity of Essential Oil of <i>Zingiber officinale</i> Roscoe (Zingiberaceae)

“…The bioassays on yeast fungi were performed by the Kirby-Bauer agar diffusion method [23] in the same way as for bacteria; in this case PDA agar was used. The fungal inoculum was diluted with saline solution (0.9%) to obtain 10 5 UFC/mL.…”

Morpho-Anatomical Profile of Elaeocarpus Tuberculatus Roxb

“…Fruits are massive, persisting into the next season. Fruit is drupe ellipsoid, laterally compressed; seed 1, ellipsoid [9] (Plate 1).…”

“…Rudraksa beads or seeds are used as a treatment for rheumatism, typhoid fever, and epilepsy, controls heartbeat, stress, anxiety, depression, palpitation [3]. Various species of Elaeocarpus have been known to possess antimicrobial [4,5], anti-arthritic [6,7], antidiabetic activities [8,9], anti-inflammatory and anti-ulcer activity [10]. Survey of the literature revealed that no anatomical studies have been carried out in this plant.…”

Coleus vettiveroides ethanolic root extract induces cytotoxicity by intrinsic apoptosis in HepG2 cells

“…In vivo and in vitro studies demonstrated the wound healing (Ponnan et al, 2019), antibacterial (Saraswathy & Lavanya, 2013), and antioxidant (Gopalakrishnan & Dhanapal, 2011) properties of CV. Further, a previous in vivo study reported that CV methanol extract was beneficial against diabetic, liver, and pancreatic ailments (Gopalakrishnan & Dhanapal, 2014). Though there are only limited studies, researchers have begun to elucidate the pharmacological properties of CV.…”