Anti-diabetic Activity of Endophytic Fungi, Penicillium Species of Tabebuia argentea; in Silico and Experimental Analysis

Murugan, Kumar Kalavathi; Poojari, Chandrappa Chinna; Ryavalad, Channabasava; Lakshmikan, Ramachandra Yarappa; Satwadi, Padmalatha Rai; Vittal, Ravishankar Rai; Govindappa, M.

doi:10.3923/rjphyto.2017.90.110

Cited by 11 publications

(3 citation statements)

References 24 publications

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“…from Taxes sumatrana cultivated in Indonesia produced the α-glycosidase inhibitor substances, include unsaturated fatty acids, specifically linolenic acids, linoleum, and oleic (Artanti et al 2012). Others compounds that showed antidiabetic activity are quinadoline A (Strobel et al 2004), scequinadoline J (Radjasa 2015), octadecanoic acid (Murugan et al 2017(Murugan et al ), scequinadoline D (Č akar et al 2018, peptide paecilodepsipeptide A (Glumac et al 2017), asperpyridone A (Ancheeva et al 2020), herbarin (Al-Hosni et al 2020, aspergiamide A, and brevianamide K (Ye et al 2021).…”

Section: Fungi Endophytes Produced Antidiabeticmentioning

confidence: 99%

Bioactivity and Metabolites Compounds of Medicinal Plants Endophytic Fungi in Indonesia

Sukmawaty,

Karim,

Dwyana

et al. 2024

J.Tropical Biodiversity Biotechnology

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Indonesia is rich in diversity of medicinal plants, vital in traditional medicine and the pharmaceutical industry. However, overharvesting, along with population growth, land use changes, deforestation, and climate change, endanger these plants. This review investigates the potential of endophytic endosymbiont as an alternative. These endosymbionts can synthesise bioactive compounds similar to those found in medicinal plants. This study compiled data from various sources on endophytic fungi and their bioactivity. The review aims to categorise Indonesian medicinal plants, to identify their associated endophytic fungi from different plant parts, and to assess their bioactivity. The results revealed numerous medicinal plant families and a variety of endophytic fungi isolated from fruits, leaves, twigs, bark, roots, and rhizomes. These fungi exhibited bioactivities, including antioxidant, anticancer, antidiabetic, and antimicrobial effects, with metabolites such as alkaloids, flavonoids, peptides, phenols, polyketides, quinones, steroids, and terpenoids. Fusarium and Colletotrichum were the most common endophytic fungi found. Notably, the biological activity was consistent among endophytic fungi from various host organs, but variations were observed according to the host's geographical origin. This suggests that Indonesia's diverse geography influences metabolite production and activity. However, the same host plant may harbour different species in distinct organs. These findings indicate that endophytic fungi within medicinal plants represent a promising source of bioactive compounds for future Indonesian medicine production. Future research should explore metabolite compounds and bioactivity across different geographical regions.

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Section: Fungi Endophytes Produced Antidiabeticmentioning

confidence: 99%

Bioactivity and Metabolites Compounds of Medicinal Plants Endophytic Fungi in Indonesia

Sukmawaty,

Karim,

Dwyana

et al. 2024

J.Tropical Biodiversity Biotechnology

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“…Penicillium sp. derived from Tabebuia argentea produced octadecanoics, a potent antidiabetic agent which inhibited all diabetic protein activity (Murugan et al 2017). Another endophytic fungi, Alternaria sp., derived from Salvadora persica produced cetene and 1,2-benzenedicarboxylic acid which showed promising antidiabetic activity (Elgorban et al 2019).…”

Section: Antidiabetic and Immunosuppressant Compounds From Endophytesmentioning

confidence: 99%

Pharmacological Applications of Bioactive Secondary Metabolites from Endophytes

Midhun

Mathew

2021

Endophytes

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Endophytes are reservoirs of new and effective bioactive compounds that generally belong to the classes such as terpenoids and steroids, fatty acid-derived substances and polyketides, alkaloids, nonribosomal polypeptides, and enzyme cofactors. These classes of compounds can be used for antimicrobial, insecticidal, cancer preventive, antioxidant, antiviral, antidiabetic, immunosuppressant, immunostimulant, and several other properties. Endophytes-derived secondary metabolites have tremendous applications in the field of agronomy, medicine, food, and cosmetics. Recent discoveries have shown that microbes associated with plants could be exploited as an important source for the development of new drugs. Finding novel molecules may combat terminal diseases, drug resistance, and other severe challenges related to human health. The newly developed drugs may be an effective contender for the treatment of newly developing diseases in humans as well as animals. This chapter aims to figure out the pharmacological uses of endophytes as a novel source of drugs against several diseases and other promising therapeutic use.

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“…Fungi produce a diversity of bioactive compounds, making them ideal for natural goods. About 130 therapeutic functions are believed to be formed by medicinal mushrooms and fungi, including antitumor ( Deshmukh et al, 2018 ; Uzma et al, 2018 ) immunomodulating ( Lull et al, 2005 ; Kanazawa et al, 2013 )antioxidant ( Sugiharto et al, 2016 ; Hameed et al, 2017 ), cardiovascular, anti parasitic, antiviral, antifungal, antibacterial, radical scavenging, hepato protective, detoxification, anti diabetic ( Murugan et al, 2017 ), anti hypercholesterolemia as well as protection against tumor development and inflammation are exhibited by fungi. Polysaccharides, alkaloids, proteins, fats, minerals, carotenoids, glycosides, terpenoids, folates, tocopherols, flavonoids, phenolics, volatile oils, ascorbic acid, lectins, enzymes, and organic acids, are bioactive molecules synthesized by different fungal organisms.…”

Section: Introductionmentioning

confidence: 99%

Fungal Mushrooms: A Natural Compound With Therapeutic Applications

Chugh

Mittal

et al. 2022

Front. Pharmacol.

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Fungi are extremely diverse in terms of morphology, ecology, metabolism, and phylogeny. Approximately, 130 medicinal activities like antitumor, immunomodulation, antioxidant, radical scavenging, cardioprotective and antiviral actions are assumed to be produced by the various varieties of medicinal mushrooms. The polysaccharides, present in mushrooms like β-glucans, micronutrients, antioxidants like glycoproteins, triterpenoids, flavonoids, and ergosterols can help establish natural resistance against infections and toxins.. Clinical trials have been performed on mushrooms like Agaricus blazei Murrill Kyowa for their anticancer effect, A. blazei Murrill for its antihypertensive and cardioprotective effects, and some other mushrooms had also been evaluated for their neurological effects. The human evaluation dose studies had been also performed and the toxicity dose was evaluated from the literature for number of mushrooms. All the mushrooms were found to be safe at a dose of 2000 mg/kg but some with mild side effects. The safety and therapeutic effectiveness of the fungal mushrooms had shifted the interest of biotechnologists toward fungal nanobiotechnology as the drug delivery system due to the vast advantages of nanotechnology systems. In complement to the vital nutritional significance of medicinal mushrooms, numerous species have been identified as sources of bioactive chemicals. Moreover, there are unanswered queries regarding its safety, efficacy, critical issues that affect the future mushroom medicine development, that could jeopardize its usage in the twenty-first century.

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Anti-diabetic Activity of Endophytic Fungi, Penicillium Species of Tabebuia argentea; in Silico and Experimental Analysis

Cited by 11 publications

References 24 publications

Bioactivity and Metabolites Compounds of Medicinal Plants Endophytic Fungi in Indonesia

Bioactivity and Metabolites Compounds of Medicinal Plants Endophytic Fungi in Indonesia

Pharmacological Applications of Bioactive Secondary Metabolites from Endophytes

Fungal Mushrooms: A Natural Compound With Therapeutic Applications

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