Anti Diabetes Mellitus Activity in vivo of Ethanolic Extract and Ethyl Acetate Fraction of Euphorbia hirta L. Herb

Widharna, Ratna Megawati; Soemardji, Andreanus A.; Wirasutisna, Komar Ruslan; Kardono, Leonardus B.S.

doi:10.3923/ijp.2010.231.240

Cited by 28 publications

(15 citation statements)

References 12 publications

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“…The study of ethanolic extracts of leaf, flower, and stem of E. hirta on streptozotocin-induced diabetic mice showed significant reduction in blood glucose levels. Biochemical effects showed significant decreases in serum cholesterol with the elevation of HDL (Widharna et al, 2010). The ethanolic and petroleum ether extracts of the flower of E. hirta also demonstrated potential antidiabetic mellitus activities in alloxan diabetic mice.…”

Section: Anti-diabetic Activitymentioning

confidence: 92%

Euphorbia hirta (Feiyangcao): A review on its ethnopharmacology, phytochemistry and pharmacology

Huang¹,

Chen²,

Yang³

2012

J. Med. Plants Res.

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A bibliographic investigation was carried out by gathering and analyzing the recognized books, including Chinese herbal classic, the Internet (Google Scholar, Baidu Scholar), and scientific databases (Pubmed, Scifinder, Scopus, CNKI, ACS, and Web of Science) for available information on Euphorbia hirta. Whole plants of E. hirta have been used in traditional Chinese medicine (TCM) due to its properties that can cure and detoxify fever, promote diuresis, stop itching, and induce prolactin. Traditional uses of E. hirta are also recorded in some other pan-tropical areas, where it has been used for over 10 types of diseases. A number of chemical constituents, including flavonoids, terpenoids and phenols, have been isolated and identified from E. hirta. Various biological evaluations have been reported for its importance. Modern pharmacological investigation demonstrated that its crude extracts and active compounds possesses wide pharmacological effects, such as antibacterial, anti-inflammatory, antioxidant, sedative and anti-allergy. The current study summarizes the updated information concerning the ethnopharmacology, phytochemistry, and pharmacology of E. hirta as well as its toxicology, and discusses the existing problem and future research direction of E. hirta.

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Section: Anti-diabetic Activitymentioning

confidence: 92%

Euphorbia hirta (Feiyangcao): A review on its ethnopharmacology, phytochemistry and pharmacology

Huang¹,

Chen²,

Yang³

2012

J. Med. Plants Res.

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“…Diabetes mellitus is one of the metabolic disorders which draw greater health concern worldwide due to its prevalent and fastest increase. [1,2] Typically, type 2 diabetes accounts 90-95% cases are anticipated to reach 221 million [3] or 366 million by 2030 [2] . Several reasons contribute to the persist and quick raising of this chronic disease owing to the genetic or acquired insulin secretion deficiency marked by diminishing of the pancreatic islet responsiveness in insulin production.…”

Section: Introductionmentioning

confidence: 99%

“…[4,5] Moreover, lifestyle change associated with bad eating habits, less exercise, and aging is another hallmark for the ever-increasing of diabetic especially type 2. [3] Therefore, paying more attention in diagnosis and assure suitable treatments is required to prevent or reduce diabetes-related short-term consequences and complications such as eye sight problem, tiredness, and hyperglycemia and long-term ones like chronic renal failure, cardiovascular disease, and neuropathy. [6] Different ways have been recommended to treat diabetes ranging from natural and synthetic way by taking chemical drug such as acarbose and metformin, change of life style by proper intake of diet and emphasize retinue exercise to control blood pressure and body over weight.…”

Section: Introductionmentioning

confidence: 99%

Purification and identification of a novel antidiabetic peptide from Chinese giant salamander (Andrias davidianus) protein hydrolysate against α-amylase and α-glucosidase

Ramadhan

Nawas

Zhang

et al. 2017

International Journal of Food Properties

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This study aimed to purify and identify a novel antidiabetic peptides from Chinese giant salamander (Andrias davidianus) protein hydrolysate and to evaluate its anti-diabetic properties against α-amylase and α-glucosidase. The isolation was done by gel filtration, reverse phase chromatography (RF-HLPC), and finally peptide and amino acid sequences were identified by LC/MS/MS system. Our results revealed five novel peptides that strongly inhibited α-amylase and αglucosidase. The peptides' amino acid sequences were Cys-Ser-Ser-Val (MW = 393.99 Da), Tyr-Ser-Phe-Arg (MW = 570.99 Da), Ser-Ala-Ala-Pro (MW = 343.89 Da), Pro-Gly-Gly-Pro (MW = 325.99 Da) and Leu-Gly-Gly-Gly-Asn (MW = 415.99 Da) possessing α-amylase inhibitory activity IC 50 of 13.76 × 10 3 , 10.82 × 10 3 , 4.46 × 10 3 , 4.23 × 10 3 , and 2.86 × 10 3 µg/mL, respectively; and for αglucosidase with IC 50 of 206. 00, 162.00, 66.90, 63.50, and 42.93 µg/mL, respectively. Intriguingly, the peptide LGGGN showed higher inhibition on both αamylase and α-glucosidase and could be considered as a potential anti-diabetic inhibitor. ARTICLE HISTORY

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“…A significant reduction in the blood glucose level was observed in streptozotocin induced diabetic mice on treatment with ethanolic extract of leaf, flower and stem of the plant. 29 Subramanian et al 24 treated the experimental diabetic rats with the leaf extract of E. hirta and found the anti-diabetic property of the extract. 24 …”

Section: Anti-diabetic Activitymentioning

confidence: 99%

Review of the phytochemical and pharmacological activities of Euphorbia hirta Linn.

Kausar¹,

Muthumani²,

Hedina³

et al. 2016

Phcogj

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The use of plant extract to cure diseases has been the traditional way used in many parts of the world. The synthetic drugs used now are more prone to cause side effects than curing the disease. Hence, the use of plant extract has now emerged due to their effective action against the disease without causing any side effects. The plants belonging to the family called Euphorbia are widely used in medicine for its wide medicinal properties. The plant Euphorbia hirta has properties like anti-bacterial, anti-diarrheal, anti-allergic, diuretic, anti-oxidant, anti-tumor, anti-diabetic, anxiolytic and sedative activity. This review contains the detailed information about all the properties of E. hirta.

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Anti Diabetes Mellitus Activity in vivo of Ethanolic Extract and Ethyl Acetate Fraction of Euphorbia hirta L. Herb

Cited by 28 publications

References 12 publications

Euphorbia hirta (Feiyangcao): A review on its ethnopharmacology, phytochemistry and pharmacology

Euphorbia hirta (Feiyangcao): A review on its ethnopharmacology, phytochemistry and pharmacology

Purification and identification of a novel antidiabetic peptide from Chinese giant salamander (Andrias davidianus) protein hydrolysate against α-amylase and α-glucosidase

Review of the phytochemical and pharmacological activities of Euphorbia hirta Linn.

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