Anti‐desmogleins autoantibodies detected by ELISA and blotting in bullous pemphigoid: what do they mean?

Abstract

In addition to antibiotics, whirlpool therapy can be used to treat erythrodermic flares of MF/SS because it reduces bacterial colonization and debrides excess scale. 5 It also decreases inflammation and promotes wound cleansing. 6 Moreover, a pilot study showed that whirlpool therapy followed by a quick rinse eradicated more than four times as many bacteria compared with whirlpool therapy alone. 7 In our protocol, the 0.25% acetic acid rinse further decreases the skin bacterial load and reduces skin pH, which inhibits S. aureus colonization.

Consensus on the treatment of autoimmune bullous dermatoses: bullous pemphigoid, mucous membrane pemphigoid and epidermolysis bullosa acquisita - Brazilian Society of Dermatology

“…The determination of antibodies against BP180 and BP230 may be necessary to confirm the diagnosis; rarely, BP patients have antibodies against desmogleins-ie, pemphigus antigens. 31,41,42 Serology may also be used for therapeutic follow-up, especially at the time of treatment discontinuation. 43…”

Anti-desmoglein autoantibody in a patient with bullous pemphigoid - A case report

“…Julio et al . [ 8 ] reported four patients with BP, out of which three had anti-Dsg1 antibodies and one had both anti-Dsg 1 and 3 in addition to BP antibodies. In BP inflammatory process leads to skin damage, which may expose other antigens such as Dsg and desmocollin.…”

“…The coexistence of anti-Dsg autoantibodies in BP patients may suggest the immunological ES phenomenon as seen in our patient. [ 8 ] Dsg1 is expressed to a higher degree in the superficial epidermis, Dsg3 is expressed in the lower portion of the epidermis, close to the basement membrane zone, where BP180 and BP230 are located. Moreover, BP mucosal impairment may expose Dsg3 to the immune system which can be explained by the presence of anti-Dsg3 antibody as seen in our patient.…”

“…Moreover, BP mucosal impairment may expose Dsg3 to the immune system which can be explained by the presence of anti-Dsg3 antibody as seen in our patient. [ 8 ]…”