Anti-damage effect of theaflavin-3′-gallate from black tea on UVB-irradiated HaCaT cells by photoprotection and maintaining cell homeostasis

Zheng, Xin; Feng, Mengyu; Wan, Juan; Shi, Yulan; Xie, Xinya; Pan, Wenjing; Hu, Baozhu; Wang, Yingzi; Huang, Wen; Wang, Kunbo; Cai, Shumin

doi:10.1016/j.jphotobiol.2021.112304

Cited by 22 publications

(15 citation statements)

References 67 publications

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“…Like EGCG, theaflavins can stimulate Aβ and α nuclide (αS) to assemble non-toxic spherical polymers, and are effective inhibitors of Aβ and αS fiber formation. Mechanism studies have shown that theaflavins have a stronger conjugation effect and phenol-qhinone balance structure than catechins, leading to stronger proton supply and nucleophilicity, which is essential to inhibit the aggregation of Aβ [65][66][67][68][69][70].…”

Section: Discussionmentioning

confidence: 99%

Inhibitory Effects of Six Types of Tea on Aging and High-Fat Diet-Related Amyloid Formation Activities

et al. 2021

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Aging and lipid metabolism disorders promote the formation and accumulation of amyloid with β-sheet structure, closely related to cardiovascular disease, senile dementia, type 2 diabetes, and other senile degenerative diseases. In this study, five representative teas were selected from each of the six types of tea, and a total of 30 teas were selected to evaluate the inhibitory activities on the formation of aging-related amyloid in vitro. The results showed that the 30 teas had a significant inhibitory effect on the formation activity on aging-related amyloid at the protein level in vitro. Although the content of catechins is relatively low, black tea and dark tea still have significant antioxidant activity and inhibit the formation of amyloid. A high-fat diet established the model of lipid metabolism disorder in premature aging SAMP8 mice, and these mice were gavaged different tea water extracts. The results showed that different tea types have a significant inhibitory effect on the formation of β-amyloid and Aβ42 mediated by age-related lipid metabolism disorders, and the in vivo activity of fully fermented teas was better than that of green tea. The action mechanism was related to antioxidation, anti-inflammatory, and improving lipid metabolism.

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Section: Discussionmentioning

confidence: 99%

Inhibitory Effects of Six Types of Tea on Aging and High-Fat Diet-Related Amyloid Formation Activities

et al. 2021

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“…Thus, finding photoprotective materials from natural resources and developing a skincare agent to protect skin against the damage stimulated by UVB irradiation is an effective strategy for skin health. Numerous natural compounds have been reported to have photoprotective effect [3][4][5][6][7]. Zheng et al investigated the photoprotective effects of theaflavins isolated from black tea.…”

Section: Introductionmentioning

confidence: 99%

“…Zheng et al investigated the photoprotective effects of theaflavins isolated from black tea. According to the findings, theaflavin-3′-gallate effectively protected human keratinocytes (HaCaT cells) against UVB-induced photodamage [6]. Li et al evaluated the protective effect of the polysaccharide isolated from Sophora japonica L. flower against UVB-induced skin damage in HaCaT cells.…”

Section: Introductionmentioning

confidence: 99%

In Vitro and In Vivo Photoprotective Effects of (-)-Loliode Isolated from the Brown Seaweed, Sargassum horneri

Wang

Kim

et al. 2021

Molecules

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Skin is the largest organ of humans. Overexposure to ultraviolet (UV) is the primary environmental factor that causes skin damage. The compound, (-)-loliode, isolated from the brown seaweed Sargassum horneri, showed strong antioxidant and anti-inflammatory activities in in vitro and in vivo models. To further explore the potential of (-)-loliode in cosmetics, in the present study, we investigated the photoprotective effect of (-)-loliode in vitro in skin cells and in vivo in zebrafish. The results indicated that (-)-loliode significantly reduced intracellular reactive oxygen species (ROS) level, improved cell viability, and suppressed apoptosis of UVB-irradiated human keratinocytes. In addition, (-)-loliode remarkably attenuated oxidative damage, improved collagen synthesis, and inhibited matrix metalloproteinases expression in UVB-irradiated human dermal fibroblasts. Furthermore, the in vivo test demonstrated that (-)-loliode effectively and dose-dependently suppressed UVB-induced zebrafish damage displayed in decreasing the levels of ROS, nitric oxide, lipid peroxidation, and cell death in UVB-irradiated zebrafish. These results indicate that (-)-loliode possesses strong photoprotective activities and suggest (-)-loliode may an ideal ingredient in the pharmaceutical and cosmeceutical industries.

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Section: Introductionmentioning

confidence: 99%

“…Several reports show that tea extract, coffee extracts, and their components have multiple bioactivities [ 10 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ]. These can be used to treat various skin conditions like wounds, cellulitis, ultraviolet (UV) damage, acne, and aging [ 15 , 16 , 17 , 18 , 19 , 20 , 21 ]. The potential topical applications of these extracts are protection from oxidative stress and UV damage [ 22 , 23 , 24 , 25 , 26 , 27 ], anti-inflammatory [ 11 , 28 , 29 ], wound-healing [ 30 , 31 , 32 , 33 ], and sunscreen properties [ 34 ].…”

Section: Introductionmentioning

confidence: 99%

Polymeric Hydrogels for Controlled Release of Black Tea and Coffee Extracts for Topical Applications

Makhija

Kathuria

Sethi

et al. 2021

Gels

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Tea and coffee are popular beverages. Both are also used in topical applications, such as ultraviolet (UV) protection, anti-aging, and wound healing. However, the impact of tea and coffee extract on skin cells is minimally explored. This study investigated the direct exposure of tea and coffee extract on skin cells using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. It was found that direct exposure of tea and coffee to skin cells can be toxic at a high dose on prolonged exposure (72 h). Therefore, it was hypothesized that a formulation providing a controlled release of tea and coffee could improve their skin compatibility. Thermally cross-linked poly(acrylic acid) hydrogels loaded with tea and coffee extracts (with and without milk) were formulated and optimized. The release profiles of these hydrogels were studied at varying loading efficiency. Milk addition with tea extract retarded the tea extract release from hydrogel while minimally affecting the coffee release. This effect was due to the molecular interaction of tea with milk components, showing changes in size, zeta potential, and polydispersity index. The release study best fitted the Korsmeyer–Peppas release model. Skin cells exposed to tea or coffee-loaded hydrogel showed normal skin cell morphology under fluorescence microscopic analysis. In conclusion, the hydrogels controlled the tea and coffee release and showed biocompatibility with skin cells. It can potentially be used for skin applications.

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Anti-damage effect of theaflavin-3′-gallate from black tea on UVB-irradiated HaCaT cells by photoprotection and maintaining cell homeostasis

Cited by 22 publications

References 67 publications

Inhibitory Effects of Six Types of Tea on Aging and High-Fat Diet-Related Amyloid Formation Activities

Inhibitory Effects of Six Types of Tea on Aging and High-Fat Diet-Related Amyloid Formation Activities

In Vitro and In Vivo Photoprotective Effects of (-)-Loliode Isolated from the Brown Seaweed, Sargassum horneri

Polymeric Hydrogels for Controlled Release of Black Tea and Coffee Extracts for Topical Applications

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