Anti–cyclic citrullinated peptide antibodies in psoriasis patients without arthritis

Böckelmann, Raik; Gollnick, Harald; Bonnekoh, Bernd

doi:10.1002/art.21804

Cited by 4 publications

(4 citation statements)

References 10 publications

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“…However, the presence of anti-CCP antibodies in PSA was significantly associated with the HLA-DR1 shared epitope (p < 0.005), and even erosive disease (p < 0.05) or a number of swollen joints (p < 0.02) (27). Interestingly, Bockelmann found 11 of 62 (17.7%) psoriasis patients with PSA had a positive anti-CCP antibody, which was significantly increased compared to the control group (4.1%, p < 0.01) (33). Gottenberg studied 134 patients with primary SS, and 10 of the 134 patients (7.5%) exhibited positive anti-CCP (30).…”

Section: Rheumatoid Factor and Anti-ccp Antibody In Rheumatoid Arthritismentioning

confidence: 99%

The Clinical Application of Anti-CCP in Rheumatoid Arthritis and Other Rheumatic Diseases

Liao

Chen

et al. 2007

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Section: Rheumatoid Factor and Anti-ccp Antibody In Rheumatoid Arthritismentioning

confidence: 99%

The Clinical Application of Anti-CCP in Rheumatoid Arthritis and Other Rheumatic Diseases

Liao

Chen

et al. 2007

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“…[ 12 ] In a study by Böckelmann et al ., anti-CCP antibodies occurred in approximately 18% of psoriasis patients not affected by any form of arthritis, relatively higher than the estimated prevalence within the general population of RA, which may suggest a subclinical or early manifestation of psoriatic arthritis or coincident RA. [ 13 ] Among the SLE group, a study reported 6.7% and 15.5% positivity for anti-CCP antibodies and RF and further concluded that anti-CCP antibodies do not associate with SLE arthritis suggesting no pathogenic role in the development of arthritis. [ 14 ]…”

Section: Discussionmentioning

confidence: 99%

Significance of anti-cyclic citrullinated peptide autoantibodies in immune-mediated inflammatory skin disorders with and without arthritis

et al. 2016

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Background:Anti-cyclic citrullinated peptides (CCPs) are autoantibodies directed against citrullinated peptides. Rheumatoid factor (RF), an antibody against the Fc portion of IgG, is known to form immune complexes and contribute to the etiopathogenesis of various skin disorders. C-reactive protein (CRP), an acute-phase protein, increases following secretion of interleukin-6 from macrophages and T cells. Anti-CCP, RF, and CRP are well-established immune-markers, their diagnostic potential in immune-mediated skin disorders remains less widely studied.Aims and Objectives:To determine the correlation between anti-CCP, RF, and CRP in immune-mediated inflammatory skin diseases.Materials and Methods:About 61 clinically diagnosed cases of various immune-mediated skin diseases (psoriasis [n = 38], connective tissue diseases such as systemic lupus erythematosus and systemic sclerosis [n = 14], and immunobullous disorders including pemphigus vulgaris and pemphigus foliaceus [n = 9]) were included in the study. These patients were subclassified on the basis of presence or absence of arthritis. Arthritis was present in nine cases of psoriasis and seven connective tissue disorder patients. Detection of serum anti-CCP was done using enzyme-linked immunosorbent assay, whereas CRP and RF levels were detected using latex agglutination technique.Results:Of the 61 specimens, 14.75% had elevated serum anti-CCP levels. RF and CRP levels were elevated in 18.03% and 39.34% specimens, respectively. RF was elevated in 13.16% of inflammatory and 42.88% of connective tissue disorders, whereas anti-CCP was raised in 10.53% of inflammatory and 35.71% of connective tissue disorders. CRP positivity was highest in connective tissue disorders (50%), followed by 39.47% in inflammatory and 22.22% in immunobullous conditions. In none of the immunobullous patients, anti-CCP or RF levels were found to be elevated. Association of the presence of arthritis with elevated anti-CCP was found to be statistically significant.Conclusions:Although anti-CCP, RF, and CRP levels are valuable markers of chronic immune-mediated skin disorders, elaborate studies enrolling a larger number of patients are required to validate these diagnostic markers.

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“…Even the diagnosis of RA is based on the detection of the anticyclic citrullinated peptide (CCP) antibodies. Anti‐CCP antibodies directed against filaggrin that aggregates cytokeratin filaments of the epidermis are also detected in psoriasis patients .…”

Section: Chemical Modifications Of Proteins and Their Role In Immune mentioning

confidence: 99%

Immune response to chemically modified proteome

Bhat

Mary

Banarjee

et al. 2014

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Both enzymatic and nonenzymatic PTMs of proteins involve chemical modifications. Some of these modifications are prerequisite for the normal functioning of cell, while other chemical modifications render the proteins as "neo-self" antigens, which are recognized as "non-self" leading to aberrant cellular and humoral immune responses. However, these modifications could be a secondary effect of autoimmune diseases, as in the case of type I diabetes, hyperglycemia leads to protein glycation. The enigma of chemical modifications and immune response is akin to the "chick-and-egg" paradox. Nevertheless, chemical modifications regulate immune response. In some of the well-known autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis, chemically modified proteins act as autoantigens forming immune complexes. In some instances, chemical modifications are also involved in regulating immune response during pathogen infection. Further, the usefulness of proteomic analysis of immune complexes is briefly discussed.

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Anti–cyclic citrullinated peptide antibodies in psoriasis patients without arthritis

Cited by 4 publications

References 10 publications

The Clinical Application of Anti-CCP in Rheumatoid Arthritis and Other Rheumatic Diseases

The Clinical Application of Anti-CCP in Rheumatoid Arthritis and Other Rheumatic Diseases

Significance of anti-cyclic citrullinated peptide autoantibodies in immune-mediated inflammatory skin disorders with and without arthritis

Immune response to chemically modified proteome

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