Anti-cyclic citrullinated peptide and rheumatoid factor in HIV positive patients

Romić, Željko; Đerek, Lovorka; Burek, Vitomir; Unić, Adriana; Serdar, Tihana; Marijančević, Domagoj; Morović‐Vergles, Jadranka; Mitrović, Joško; Petrovečki, Mladen

doi:10.1007/s00296-010-1539-6

Cited by 12 publications

(7 citation statements)

References 13 publications

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“…antinuclear antibodies, have been detected in higher frequency than in matched controls (10). Likewise, rheumatoid factor is found in every tenth HIV-infected patient (11), anti-neutrophilic antibodies in up to 42% (12,13) and anti-cardiolipin antibodies in 36-67% (14). Of note, these autoantibodies are generally present at low titres and may have little, if any, clinical relevance.…”

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confidence: 97%

Prevalence of Skin-specific Autoantibodies in HIV-infected Patients and Uninfected Controls

Touzeau‐Roemer¹,

Skoll²,

Tajpara³

et al. 2019

Acta Derm Venerol

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This is an open access article under the CC BY-NC license. www.medicaljournals.se/acta Acta Derm Venereol 2019; 99: 978-983 978 SIGNIFICANCEThe simultaneous occurrence of HIV-related immunodeficiency and autoimmune diseases is clearly documented. This cross-sectional study including 594 HIV-infected patients and 248 healthy controls lacking signs of autoimmune blistering skin diseases evaluated the frequency, titres and combinational appearance of autoantibodies directed against BP180, BP230, desmoglein 1 and 3, and showed no differences between the 2 patient groups. Interestingly, reactive syphilis serology in both HIV-infected individuals and uninfected controls was associated with positive anti-BP180 ELISA results, prompting a further evaluation for syphilis antibodies in patients with positive BP180 ELISA results and no clinical signs of bullous pemphigoid.Various autoantibodies are detected more frequently in HIV-infected individuals than in HIV-negative controls; however, limited data exist regarding autoimmune blistering skin diseases. Using enzyme-linked immunoassay (ELISA) and indirect immunofluore scence, no difference in the frequency and magnitude of autoantibodies against BP180, BP230, desmoglein 1 and 3 was found between 594 HIV-infected patients and 248 uninfected controls in this cross-sectional study (16.0% vs. 11.7%, respectively, for at least one positive ELISA, p = 0.11). Interestingly, reactive syphilis serology in both HIV-infected individuals and uninfected controls was associated with positive anti-BP180 ELISA results (adjusted odds ratio (OR) 2.14, 95% confidence interval (CI) 1.07-4.29, p = 0.03 and OR 4.70, CI 1.3-16.86; p = 0.0180). Our study shows a comparably low prevalence of cutaneous autoantibodies in both HIV-infected patients and uninfected controls lacking signs of autoimmune blistering skin disease. Positive BP180 ELISA in the absence of clinical signs of bullous pemphigoid should prompt further evaluation for syphilis antibodies.

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confidence: 97%

Prevalence of Skin-specific Autoantibodies in HIV-infected Patients and Uninfected Controls

Touzeau‐Roemer¹,

Skoll²,

Tajpara³

et al. 2019

Acta Derm Venerol

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“…Which support positivity of anti-CCP in human immunodeficiency virus infection. 9,10 In this study, 30.2% cases of total pulmonary tuberculosis were sputum positive and 69.8% cases were sputum negative. Vikram et al, also had similar observation, their study had 29.0% sputum positive and 70.9% sputum negative cases of pulmonary tuberculosis.…”

Section: Discussionmentioning

confidence: 49%

Anti- cyclic citrullinated peptide antibodies in tuberculosis and human immunodeficiency virus

et al. 2020

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Background: Anti-cyclic citrullinated peptide (anti-CCP) antibodies have been considered very specific for rheumatoid arthritis (RA). Some studies have shown that these antibodies can be positive in infectious diseases like tuberculosis, human immunodeficiency virus infection, etc.Methods: Eighty patients of tuberculosis both pulmonary and extra-pulmonary tuberculosis and thirty patients of human immunodeficiency virus were enrolled in this study from inpatient and outpatient departments from September 2018 to August 2019. Anti-CCP antibody test was done in all the patient by enzyme linked immunosorbent assay.Results: Fifty-three patients were of pulmonary tuberculosis, 27 patients were extra-pulmonary tuberculosis and 30 patients were human immunodeficiency virus infection. Of the 53 cases of pulmonary tuberculosis, 21 (39.6%) cases were positive for anti-CCP antibodies and 32 (60.4%) cases were negative for the same. Of the 27 cases of extra-pulmonary tuberculosis, 3(11.1%) cases were positive for anti-CCP antibodies and 24 (88.9%) cases were negative. Of the 53 patients of pulmonary tuberculosis, 16 were sputum positive and 37 were sputum negative. Of those withsputum positive 9 (56.2%) cases were positive for anti-CCP antibodies and those with sputum negative, 12 (32.4%) cases were positive for anti-CCP antibodies. Of the 30 cases of human immunodeficiency virus, 5 (16.7%) cases were positive for anti-CCP antibodies and 25 (83.3%) cases were negative.Conclusions: Anti-CCP can be positive in cases of infectious diseases like tuberculosis and human immunodeficiency virus. Positivity of anti-CCP antibodies for tuberculosis is more for pulmonary (more for sputum-positive than sputum-negative) than extra-pulmonary tuberculosis. Anti-CCP, thus is not very specific for rheumatoid arthritis.

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“…ACPA have similar sensitivity as RF to RA but with a higher specificity (90-95%), thus, allowing more accurate diagnosis of RA, especially in cases of early undifferentiated arthritis (8,9). However, this test is not 100% specific, and ACPA positivity has been reported in a variety of diseases (21)(22)(23)(24)(25). As this case highlights, the presence of ACPA in the context of a polyarthritis should not exclude automatically other diagnostic entities, particularly in elderly patients with consumptive symptoms.…”

Section: Discussionmentioning

confidence: 99%

Gastric Adenocarcinoma Presenting as a Rheumatoid Factor and Anti-cyclic Citrullinated Protein Antibody-Positive Polyarthritis: A Case Report and Review of Literature

Silvério-António

Parlato²,

Martins

et al. 2021

Front. Med.

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A 64-year-old male presented with a 6-month history of symmetric polyarthritis involving proximal interphalangeal joints and metacarpophalangeal joints of the hands, wrists, and ankles. Associated symptoms included vomiting, progressive fatigue, and weight loss. Laboratory results showed microcytic anemia, leukocytosis, thrombocytosis, elevated C-reactive protein and erythrocyte sedimentation rate, and rheumatoid factor (RF) and anti-cyclic citrullinated protein (ACPA) antibody positivity. Joints radiographs were normal, without erosions. Upper endoscopy and gastric endoscopic ultrasonography showed a gastric adenocarcinoma with lymphatic involvement. Intraoperatively, peritoneal carcinomatosis was documented, and the patient started palliative chemotherapy. A paraneoplastic seropositive arthritis was assumed, and treatment with low-dose prednisolone and hydroxychloroquine was started. Arthritis remission was achieved and sustained up to 18 months of follow-up, although gastric cancer progression was documented. We describe a unique phenotype of paraneoplastic arthritis (PA) presenting as a seropositive (RF and ACPA positivity) rheumatoid arthritis (RA) with a good response to both low dose corticosteroids and hydroxychloroquine therapy. We also review the literature of PA, mostly the RA-like pattern, and the association between PA and ACPA positivity. This case highlights the importance of considering underlying cancer in elderly male patients, presenting with polyarthritis and systemic symptoms, even in those with ACPA-positive RA-like arthritis.

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Anti-cyclic citrullinated peptide and rheumatoid factor in HIV positive patients

Cited by 12 publications

References 13 publications

Prevalence of Skin-specific Autoantibodies in HIV-infected Patients and Uninfected Controls

Prevalence of Skin-specific Autoantibodies in HIV-infected Patients and Uninfected Controls

Anti- cyclic citrullinated peptide antibodies in tuberculosis and human immunodeficiency virus

Gastric Adenocarcinoma Presenting as a Rheumatoid Factor and Anti-cyclic Citrullinated Protein Antibody-Positive Polyarthritis: A Case Report and Review of Literature

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