Anti-convulsant Effects of Bongardia chrysogonum L. Tuber in the Pentylenetetrazole-induced Seizure Model

Abuhamdah, Sawsan; Abuirmeile, Amjad Naji; Thaer, Fadwa; Al-Olimat, Suleiman; Abdel, Ennaceur; Chazot, Paul L.

doi:10.3923/ijp.2018.127.135

Cited by 2 publications

(2 citation statements)

References 23 publications

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“…Pentylenetetrazole (PTZ) is a non-conventional drug (a convulsant) that induces seizures by disrupting neural activity when administered at a lethal dose (85 mg/kg b.w in rats). The mechanism underlying PTZ-induced seizures is thought to involve direct non-competitive antagonism of GABAA receptors that acts through t-butyl-bicyclophosphorothionate site of the receptor to decrease its activity [7,8].…”

Section: Introductionmentioning

confidence: 99%

Antiepileptic Effect of Musa paradisiaca Stem Juice on Pentylenetetrazole (PTZ)-induced Seizures in Albino Rats

Chinweike UGWUOKE,

NWANELO,

OGUGOFOR

et al. 2023

jrp

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Musa paradisiaca stem juice (MPSJ) found an extensive use in folklore medicine, but its antiepileptic properties are yet to be scientifically proven, hence, the aim of this study. Pentylenetetrazole (PTZ)-induced seizure model was adopted, involving twenty-four (n=24) adult male albino rats, randomly distributed into six (6) groups of four animals each (n=4). Group 1 received saline (p.o); group 2 was untreated; group 3 received 4 mg/kg b.w diazepam (p.o); while groups 4, 5 and 6 received 50, 75 and 100% (v/v) of MPSJ (p.o), respectively. The treatment lasted for 10 days before rats were challenged with PTZ (85 mg/kg b.w, i.p) after 45 min. Group 6 showed a significant (p < 0.05) increase in brain GABA level compared to that of the untreated group. Groups 5 and 6 showed a significant (p < 0.05) reduction in glutamate level and GABA-T activities compared to that of group 2. There were significant (p < 0.05) increases in the levels of CAT and SOD of group 6 rats compared to those of the untreated groups, except the GSH that was not statistically significant (p > 0.05). Group 6 showed a significantly (p < 0.05) higher SOD concentration when compared to group 2. The MDA level of group 4 was significantly (p < 0.05) reduced compared to that of group 2. The neuronal necrosis produced by PTZ was ameliorated in group 4 rats and the normal histo-architecture of the brain was restored. This study suggests MPSJ has protective effects against PTZ-induced seizures in rats.

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Section: Introductionmentioning

confidence: 99%

Antiepileptic Effect of Musa paradisiaca Stem Juice on Pentylenetetrazole (PTZ)-induced Seizures in Albino Rats

Chinweike UGWUOKE,

NWANELO,

OGUGOFOR

et al. 2023

jrp

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“…Although L. leontopetalum and B. chrysogonum have been used as medicinal plants for treatment of epilepsy in humans, there is no available research regarding the effect of L. leontopetalum aqueous root extract on any chronic models of epilepsy in experimental models. In a very recently study, in vitro antioxidant and free-radical scavenging properties and anticonvulsant activity (in mice) of B. chrysogonum root extract was reported (14). Therefore, the aim of this study was to determine the anticonvulsant, antioxidant, and neuroprotective effects of L. leontopetalum and B. chrysogonum, which belong to the same family, extracts and associated seizure-induced neuronal loss and alterations in the gamma-aminobutyric acid (GABA A ) receptor number in a PTZ kindling model of epilepsy in rats.…”

Section: Introductionmentioning

confidence: 99%

Effects of Leontice leontopetalum and Bongardia chrysogonum on oxidative stress and neuroprotection in PTZ kindling epilepsy in rats

Erkeç

Arıhan

Kara

et al. 2018

Cell Mol Biol (Noisy-le-grand)

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We investigated the effects of Leontice leontopetalum and Bongardia chrysogonum on apoptosis, gamma-aminobutyric acid (GABA A ) receptor positive cell number, cyclin-B1 and bcl-2 levels and oxidative stress in pentylenetetrazol (PTZ) kindling in rats. Kindling was produced by subconvulsant doses of PTZ treatments in rats. Wistar albino rats were divided into 4 groups; Control, PTZ treated (PTZ), PTZ+L. leontopetalum extract treated (PTZ+LLE) and PTZ+B. chrysogonum extract treated (PTZ+BCE) groups. Extracts were given a dose (200 mg/kg) 2h before each PTZ injection. PTZ treatment significantly decreased the glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) activities and bcl-2 levels and increased the total oxidant status (TOS), malondialdehyde (MDA), cyclin B1, oxidative stress index (OSI) and number of neurons that expressed GABA A receptors when compared to the control. LLE and BCE possessed antioxidant activity in the brain and ameliorated PTZ induced oxidative stress, decreased cyclin-B1, increased bcl-2 levels, and kept the GABA A receptor number similar to that of the control despite the PTZ application.

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Anti-convulsant Effects of Bongardia chrysogonum L. Tuber in the Pentylenetetrazole-induced Seizure Model

Cited by 2 publications

References 23 publications

Antiepileptic Effect of Musa paradisiaca Stem Juice on Pentylenetetrazole (PTZ)-induced Seizures in Albino Rats

Antiepileptic Effect of Musa paradisiaca Stem Juice on Pentylenetetrazole (PTZ)-induced Seizures in Albino Rats

Effects of Leontice leontopetalum and Bongardia chrysogonum on oxidative stress and neuroprotection in PTZ kindling epilepsy in rats

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