Anti-conjunctivitis effect of fresh juice of xGraptoveria (Crassulaceae) - a phytochemical and ethnobotanical study

Маркова, Н.; Batovska, Daniela; Kozuharova, Ekaterina; Enchev, Venelin

doi:10.5455/jice.20141104014605

Cited by 3 publications

(2 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was found that GP aqueous extracts show anti-inflammatory [14], antioxidant [15] and antineoplastic activities [16]. Preliminary phytochemical studies on the effect of n-butanol extract from fresh watery juice of GP leaves demonstrate anticonjunctivitis activity due to probable synergistic effect between alkylamines, hydroxycarboxylic, aliphatic and aromatic carboxylic acids [17]. Published data [18] suggest that the GP polyphenolic fraction inhibits hepatitis B virus (HBV) replication, gluconeogenesis and lipogenesis and could be used for treatment of chronic HBV patients.…”

Section: Introductionmentioning

confidence: 99%

Anti-Herpes Simplex virus and antibacterial activities of Graptopetalum paraguayense E. Walther leaf extract: a pilot study

Zaharieva

Genova-Kalоu

Dincheva

et al. 2019

Biotechnology & Biotechnological Equipment

Self Cite

View full text Add to dashboard Cite

Graptopetalum paraguayense E. Walther (GP) belongs to the Crassulaceae family and has several health benefits. In the present study we evaluated the cytotoxic, anti-Herpes Simplex virus (HSV) and antibacterial activities of a total methanol/water GP extract. The results from the cytotoxicity investigation of the tested extract showed a high cell tolerable concentration range. The GP extract demonstrated a significant inhibitory effect on the wild-type HSV-1 strain Victoria in a concentration of 0.0001 mg/mL equal to the maximal nontoxic concentration (with 97.5% protection of the cells). Regarding the acyclovir-resistant mutant HSV-2 strain PU and wild-type HSV-2 strain Bja, the antiviral activity and selectivity of the extract were very low, with EC 50 values from 0.1 to 0.01 mg/mL, and the selectivity index ranging from 25 to 250, respectively. The GP extract exhibited selective inhibitory activity also on the growth of Gram-positive bacterial pathogens, with Staphylococcus aureus being most sensitive. It also prevented the formation of MRSA biofilm up to 50% at a concentration of 1.6 mg/mL and up to 90% at a concentration of 2.5 mg/mL. The anti-herpetic and antibacterial activities demonstrated in our investigation are probably related to the presence of phenols, and in particular gallic acid. The antimicrobial activity of the GP extract holds a promise for the future development of nutrition supplements based on G. paraguayense and therefore warrants further studies aimed at isolating biologically active compounds or mixtures thereof with subsequent in-depth investigation of their anti-HSV and antibacterial mechanisms of action.

show abstract

Section: Introductionmentioning

confidence: 99%

Anti-Herpes Simplex virus and antibacterial activities of Graptopetalum paraguayense E. Walther leaf extract: a pilot study

Zaharieva

Genova-Kalоu

Dincheva

et al. 2019

Biotechnology & Biotechnological Equipment

Self Cite

View full text Add to dashboard Cite

show abstract

“…In these studies, awareness of medicinal plants was monitored, as well as their potential adverse effects [21] and sources of information about them [22,23]. At the same time, the proportion of studies that seek to validate available or newly documented ethnobotanical information remains low [24].…”

Section: Introductionmentioning

confidence: 99%

Ethnobotanical and Ethnopharmacological Study in the Bulgarian Rhodopes Mountains—Part _I

Mincheva

Naychov

Radev³

et al. 2022

Diversity

Self Cite

View full text Add to dashboard Cite

Traditional knowledge of medicinal plants and their uses has been well documented in Bulgaria in the past. However, we know little about the contemporary traditional application of medicinal plants. Rhodopes Mountain is an ethnobotanically poorly studied region. This region is suitable for conducting field research in ethnobotany for several reasons: (i) our preliminary observation in a number of settlements revealed that the local population, in particular, relies solely on previously collected medicinal plants in winter months even in modern times; (ii) due to the relative isolation of the area, considerable authenticity of traditional methods of medicinal plant use is retained there. The aim of this study is ethnopharmacological and ethnobotanical research among the population of the Rhodopes to evaluate the contemporary use of medicinal plants. The field ethnobotanical data were collected through the in-depth method in combination with a semi-structured face-to-face interviews, adapted with modifications to the objectives of this study. The quantitative ethnobotanical index Use Value (UV) was calculated. Here we suggested a new approach in ethnobotanical research. We used nomograms to present a large volume of medicinal plants’ application data, classified by the degree of their UV. This allows for a much broader view of collected and processed data. Data analyses from our filed research showed that the 92 informants mentioned utilization of a total of 114 plant species belonging to 52 families and 110 genera. The most common plants were from the families Asteraceae (16.7%), Lamiaceae (12.3%), Rosaceae (9.6%) and Amrillydaceae (3.5%), followed by Crassulaceae, Plantaginacea, Oleaceae and Solanaceae. The data presented in six nomograms revealed the most popular plants, the way of application and the corresponding medical indications in the Central and East Rhodopes, and the differences between the two sub-regions. Sempervivum tectorum, Tussilago farfara and Plantago major are the most often reported plants in the Central Rhodopes while these are Cotinus coggygria, Prunus spinosa and Teucrium polium in the East Rhodopes. The results of the study show that in the Rhodopes, the contemporary application of traditional medicinal plants is pretty much vivid. The locals in the Rhodopes still use the traditional knowledge and rely on plants to treat various health problems. They use common plants in a sustainable manner and are open to the cultivation of Sideritis scardica—a species which became rare after overexploitation.

show abstract

Ethnobotanical and Ethnopharmacological Study in the Bulgarian Mountain Rhodopes: Part II—Contemporary Use of Medicinal Plants

Mincheva

Naychov

Radev³

et al. 2023

Diversity

View full text Add to dashboard Cite

Rhodopes Mountain is ethnobotanically poorly studied, but our preliminary observation in a number of settlements revealed that even nowadays, the local population relies solely on previously collected medicinal plants. We aimed to assess the contemporary use of medicinal plants in the Central and East Rhodopes and the health conditions that local communities address with them. The ethnobotanical field data were collected through an in-depth method in combination with semi-structured face-to-face interviews, adapted with modifications to the objectives of this study. The following quantitative ethnobotanical indices were used in this study: informant consensus factor (ICF), fidelity level (FL), and Jaccard similarity coefficient or Jaccard index (JI). Data analyses from our field research showed that 92 informants mentioned the utilization of a total of 114 plant species. The results of this study reveal that in both regions of the Rhodopes, medicinal plants are mentioned most often in relation to diseases affecting nervous, respiratory, digestive, and cardiovascular systems, followed by reproductive, urinary, immune, and musculoskeletal. The risk of disruption or loss of traditional knowledge of medicinal plants is expected in the condition of cultural globalization. However, there is no metrified data about the use of medicinal plants in the Rhodopes from the past. The application of statistical indices in this research will make such assessment and monitoring possible in the future.

show abstract

Anti-conjunctivitis effect of fresh juice of xGraptoveria (Crassulaceae) - a phytochemical and ethnobotanical study

Cited by 3 publications

References 17 publications

Anti-Herpes Simplex virus and antibacterial activities of Graptopetalum paraguayense E. Walther leaf extract: a pilot study

Anti-Herpes Simplex virus and antibacterial activities of Graptopetalum paraguayense E. Walther leaf extract: a pilot study

Ethnobotanical and Ethnopharmacological Study in the Bulgarian Rhodopes Mountains—Part _I

Ethnobotanical and Ethnopharmacological Study in the Bulgarian Mountain Rhodopes: Part II—Contemporary Use of Medicinal Plants

Contact Info

Product

Resources

About