Anti-Colon Cancer and Antibiofilm Activities of Green Synthesized ZnO Nanoparticles Using Natural Polysaccharide Almond Gum (Prunus dulcis)

Vijayakumar, Sekar; Chen, Jingdi; González-Sánchez, Zaira Isabel; Durán-Lara, Esteban F.; Divya, Mani; Shreema, Krishnan; Hadem, Hushnaara; Mathammal, R.; Prasannakumar, Murugesan; Vaseeharan, Baskaralingam

doi:10.1007/s10876-021-02205-2

Cited by 8 publications

(5 citation statements)

References 63 publications

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“…These results prove that the biosynthetic ZnONPs are more effective and inhibiting on cancer cell lines and safer, less expensive and easier to prepare than other methods (physical or chemical). These results are consistent with the findings of studies [22][23][24][25][26] . The cytotoxicity of biosynthetic ZnONPs may be due to the release of dissolved zinc ions within cells and the induction of reactive oxygen species (ROS).…”

Section: Discussionsupporting

confidence: 93%

Biosynthetic of Green Zinc Oxide Nanoparticles with Effect on Cancer Cell Line Hela

Alzubaidy

Hussain

2023

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The cytotoxic impact of biosynthetic zinc oxide nanoparticles (ZnONPs) was investigated using Vitex agnus-castus, which has been shown to have Effective compounds that suppress cancer cell proliferation. Zinc oxide nanoparticles were biosynthesized in the laboratories of the Biology department /College of Education for the Pure Sciences /University of Diyala. The phenotypic and structural characteristics of biosynthetic nanoparticles were identified using scanning electron microscopy (SEM). The majority of ZnONPs are dense and spherical in shape, with diameters ranging from (20-61) nm, and were discovered on the cervical cancer cell line Hela and compared to the normal line Human Foreskin Fibroblast cells (HFF) using the MTT stain test (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium ). Cytotoxicity experiments were conducted at the Iraqi Center for Cancer Research / Al-Mustansiriya University. This study showed inhibitory activity on Hela cervical cancer cells, where the highest inhibition rate reached 93.6% at a concentration of 200 µg/ml. This raises the prospect of finding a viable therapy for cervical cancer (Hela) or any other malignancy using nanoparticle manufacturing technologies. Keywords: Biosynthetic, Green nanoparticles, Cancer cell, Hela, GC-MS.

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Section: Discussionsupporting

confidence: 93%

Biosynthetic of Green Zinc Oxide Nanoparticles with Effect on Cancer Cell Line Hela

Alzubaidy

Hussain

2023

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“…The body synthesizes antibodies against many diseases like chronic inflammation, and autoimmune disease in cancer treatment when the immune system is activated. Scientists reported that Au NPs were synthesized by using bacteria, fungi, bioextracts, and plant extracts such as Diospyros kaki, Magnolia kobus, Shewanella oneidensis, and Yarrowia lipolytic, which played an immense role in enhancing the body's immune system during cancer therapy and removes inflammation [150]. A study revealed that Au NPs utilizing Hygrophila spinosa leaf extract showed anticancer, antibacterial, and antifungal activity against several tested pathogens [151].…”

Section: A Nigermentioning

confidence: 99%

Breaking Barriers in Eco-Friendly Synthesis of Plant-Mediated Metal/Metal Oxide/Bimetallic Nanoparticles: Antibacterial, Anticancer, Mechanism Elucidation, and Versatile Utilizations

Dubey,

Virmani,

Yadav

et al. 2024

Journal of Nanomaterials

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Nanotechnology has emerged as a promising field in pharmaceutical research, involving producing unique nanoscale materials with sizes up to 100 nm via physiochemical and biological approaches. Nowadays more emphasis has been given to eco-friendly techniques for developing nanomaterials to enhance their biological applications and minimize health and environmental risks. With the help of green nanotechnology, a wide range of green metal, metal oxide, and bimetallic nanoparticles with distinct chemical compositions, sizes, and morphologies have been manufactured which are safe, economical, and environment friendly. Due to their biocompatibility and vast potential in biomedical (antibacterial, anticancer, antiviral, analgesic, anticoagulant, biofilm inhibitory activity) and in other fields such as (nanofertilizers, fermentative, food, and bioethanol production, construction field), green metal nanoparticles have garnered significant interest worldwide. The metal precursors combined with natural extracts such as plants, algae, fungi, and bacteria to get potent novel metal, metal oxide, and bimetallic nanoparticles such as Ag, Au, Co, Cu, Fe, Zr, Zn, Ni, Pt, Mg, Ti, Pd, Cd, Bi2O3, CeO2, Co3O4, CoFe2O4, CuO, Fe2O3, MgO, NiO, TiO2, ZnO, ZrO2, Ag-Au, Ag-Cr, Ag-Cu, Ag-Zn, Ag-CeO2, Ag-CuO, Ag-SeO2, Ag-TiO2, Ag-ZnO, Cu-Ag, Cu-Mg, Cu-Ni, Pd-Pt, Pt-Ag, ZnO-CuO, ZnO-SeO, ZnO-Se, Se-Zr, and Co-Bi2O3. These plant-mediated green nanoparticles possess excellent antibacterial and anticancer activity when tested against several microorganisms and cancer cell lines. Plants contain essential phytoconstituents (polyphenols, flavonoids, terpenoids, glycosides, alkaloids, etc.) compared to other natural sources (bacteria, fungi, and algae) in higher concentration that play a vital role in the development of green metal, metal oxide, and bimetallic nanoparticles because these plant-phytoconstituents act as a reducing, stabilizing, and capping agent and helps in the development of green nanoparticles. After concluding all these findings, this review has been designed for the first time in such a way that it imparts satisfactory knowledge about the antibacterial and anticancer activity of plant-mediated green metal, metal oxide, and bimetallic nanoparticles together, along with antibacterial and anticancer mechanisms. Additionally, it provides information about characterization techniques (UV–vis, FT-IR, DLS, XRD, SEM, TEM, BET, AFM) employed for plant-mediated nanoparticles, biomedical applications, and their role in other industries. Hence, this review provides information about the antibacterial and anticancer activity of various types of plant-mediated green metal, metal oxide, and bimetallic nanoparticles and their versatile application in diverse fields which is not covered in other pieces of literature.

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“…The almond gum-coated magnesium nanoparticles were synthesized by following the previous method with some modi cations [43]. In a typical one-pot green synthesis, separate solutions were formed by dissolving 1gm of almond gum and 2.56gm of magnesium nitrate in 100 ml of double-distilled water.…”

Section: Synthesis Of Almond Gum Coated Mgo Nanoparticlesmentioning

confidence: 99%

Facile one-pot green synthesis of almond gum coated MgO nanoparticles for Biological applications

Ganapathi

Balasubramanian

Balalakshmi

2023

Preprint

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The increasing resistance of pathogens and cancer cells to antibiotics and anticancer drugs has sparked the discovery of novel therapeutic materials. Recently, the utilization of plant compounds and byproducts in nanomaterials fabrications has great attention in biomedicine and bioremediation. In this work, almond gum coated MgO nanoparticles were synthesized by a simple green synthesis method. The physicochemical properties of prepared nanoparticles were systematically evaluated using various microscopic and spectroscopy techniques. The biological potential of AG@MgO nanoparticles was evaluated against human infectious pathogens, (Streptococcus pneumoniae, Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae). The anticancer potential of nanoparticles was assessed against MCF-7 a breast cancer cell which shows excellent cell damage in the lowest concentration. The larvicidal potential of nanoparticles was evaluated against Aedes aegypti mosquito larvae, the mortality rate of larvae increases as the concentration ratio of AG@MgO nanoparticles increases. The final results concluded that the AG@MgO nanoparticles efficiently control bacterial, breast cancer cell growth, and mosquito larvae.

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Anti-Colon Cancer and Antibiofilm Activities of Green Synthesized ZnO Nanoparticles Using Natural Polysaccharide Almond Gum (Prunus dulcis)

Cited by 8 publications

References 63 publications

Biosynthetic of Green Zinc Oxide Nanoparticles with Effect on Cancer Cell Line Hela

Biosynthetic of Green Zinc Oxide Nanoparticles with Effect on Cancer Cell Line Hela

Breaking Barriers in Eco-Friendly Synthesis of Plant-Mediated Metal/Metal Oxide/Bimetallic Nanoparticles: Antibacterial, Anticancer, Mechanism Elucidation, and Versatile Utilizations

Facile one-pot green synthesis of almond gum coated MgO nanoparticles for Biological applications

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