Anti-Coagulation Activities of Malaysian Mikania cordata Leaves

Shafee, Wan Norshazwani Wan; Yusof, Nur Yuzaiza; Fauzi, Hafizuddin Mohamed; Lim, Vuanghao; Kamalaldin, Nurulain Atikah; Yahaya, Badrul Hisham

doi:10.1007/s10989-018-9742-5

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…In accordance with those findings reported in literature caffeic acid or its derivatives can be strong candidates for their observed effects on blood coagulation. Our findings were also in accordance with those reported in the literature [25][26][27][28][29][30]. The extracts with relatively high caffeic acid and other phenolic acids contents acted as an anti-coagulant substance.…”

Section: Hplc and Lc-qtof-ms Analysessupporting

confidence: 93%

Evaluation of the hemostatic activity of Equisetum arvense extract: the role of varying phenolic composition and antioxidant activity due to different extraction conditions

2019

Biointerface Res Appl Chem

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Hemostasis is a procedure that causes bleeding to stop and is very important in injuries. Recent researches were focused on the discovery of plant hemostatic agents. Therefore, plant extracts were investigated as a major source as a hemostatic agent. In this research, Equisetum arvense extract was investigated as a candidate coagulatory agent. Effect of extraction parameters on coagulation was investigated. Although it has been stated in the literature that the extract of Equisetum arvense has anticoagulatory activity, it has been shown in this study that alteration of the extraction parameters changes the extract bioactivity from the anticoagulant to the coagulant.

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Section: Hplc and Lc-qtof-ms Analysessupporting

confidence: 93%

Evaluation of the hemostatic activity of Equisetum arvense extract: the role of varying phenolic composition and antioxidant activity due to different extraction conditions

2019

Biointerface Res Appl Chem

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Synergistic inhibition effect of Mikania micrantha extract with KI on steel corrosion in H2SO4 solution

Tang

Deng

et al. 2021

Journal of Molecular Liquids

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In Vitro Anticoagulant Activity of Mikania laevigata: Deepening the Study of the Possible Interaction Between Guaco and Anticoagulants

Leite

Miranda

Amorim

et al. 2019

Journal of Cardiovascular Pharmacology

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Mikania laevigata, popularly known in Brazil as guaco, is widely used for respiratory disorders. As this plant is rich in coumarins, there is evidence of indications that it may cause bleeding and therefore should not be used concomitantly with anticoagulants. The basis of this information is very theoretical, with no clinical evidence of such contraindication. Thus, the aim of this study was to evaluate the in vitro effect of M. laevigata extract on blood coagulation through prothrombin time (PT) and activated partial thromboplastin time (aPTT) tests, fibrinogen plasma concentration, and the new thrombin generation test, which investigate, with high sensibility, hemostatic changes (CAAE 60904316.6.0000.5149), besides evaluating its qualitative micromolecular composition, providing scientific evidence to support the management of patients taking warfarin. Ethanolic extracts of guaco leaves were incubated with a plasma pool of healthy individuals at concentrations of 1.67, 2.26, and 2.86 mg/mL. The presence of flavonoids, tannins, coumarins, and triterpenes was demonstrated by selective reagents in thin layer chromatography. Benzoylgrandifloric acid, cinnamoylgrandifloric acid, o-coumaric acid, coumarin, and quercetin-3-β-glucoside were identified by coinjection in ultraperformance liquid chromatography. The extract at all concentrations prolonged TP and aPPT and reduced the potential for endogenous thrombin potential by the thrombin generation test. The control plasma had endogenous thrombin potential = 1465 nM/min, and after the addition of M. laevigata extract (2.26 mg/mL), this value was reduced to 1087 nM/min, indicating a lower generation of thrombin. Related to fibrinogen plasma concentration, concentrations of 2.26 and 2.86 mg/mL were effective in reducing plasma fibrinogen levels. These results allow us to conclude that the guaco extract demonstrated an anticoagulant effect in vitro, possibly interfering with intrinsic, extrinsic, and common coagulation pathways. A discussion on the contribution of the identified substances to the activity is also present.

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Anti-Coagulation Activities of Malaysian Mikania cordata Leaves

Cited by 3 publications

References 11 publications

Evaluation of the hemostatic activity of Equisetum arvense extract: the role of varying phenolic composition and antioxidant activity due to different extraction conditions

Evaluation of the hemostatic activity of Equisetum arvense extract: the role of varying phenolic composition and antioxidant activity due to different extraction conditions

Synergistic inhibition effect of Mikania micrantha extract with KI on steel corrosion in H2SO4 solution

In Vitro Anticoagulant Activity of Mikania laevigata: Deepening the Study of the Possible Interaction Between Guaco and Anticoagulants

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