Anti‐Co^a implicated in severe haemolytic disease of the foetus and newborn

Abstract

BACKGROUND Haemolytic disease of foetus and newborn (HDFN) is triggered by enhanced destruction of red blood cell due to immune-mediated destruction, intrinsic abnormalities, acquired aberrations, etc. Lifespan of infant's erythrocytes are shortened by the action of placentally transferred maternal antibodies in immune-mediated HDFN. The aim of this study was to identify the frequency of maternal antibodies in neonates with hyperbilirubinaemia. Settings and Design-This was a cross-sectional study in neonates admitted to neonatal intensive care unit (NICU). Setting for the research was Dept. of Transfusion Medicine and Neonatology division of Sree Avittom Thirunal Hospital for women and children attached to Govt. Medical College, Trivandrum.

Management of anti‐Coltona alloimmunisation in pregnancy: a case report

“…Unfortunately, a clear cutoff for anti-Co a antibody titres, leading to foetal anaemia, is lacking (de Haas et al, 2015). In our and other cases of severe foetal anaemia, the antibody titre was measured at a level of 1 : 128 in IAT and in a case of mild HDFN the titer was only 1 : 32 (Simpson, 1973;McIntyre et al, 1976;Michalewska et al, 2008). Here, however, it is important to consider the different methods of antibody titre determination used in the 1970s and nowadays.…”

“…This method was used in the four cases in the 1970s, but required repeated amniocentesis with the risks of an invasive procedure (Simpson, 1973;McIntyre et al, 1976;Fuhrmann et al, 1979). Measurement of the MCA-PSV is the gold standard nowadays and was performed in our and Michalewska's case (Mari et al, 1995;Michalewska et al, 2008). Compared with that case, where MoM-values for the MCA-PSV cutoff were used, we used the reference values published by Kurmanavicius et al (2001) (Mari et al, 1995).…”

Incompatible red blood cell transfusion for hemolytic disease of the fetus and newborn secondary to anti‐U: A case report

“…Using maternal blood for intrauterine or neonatal transfusion has been reported in some cases where blood lacking a high‐prevalence antigen could not otherwise be procured. These include a patient with anti‐Ku, 17 a patient with anti‐Jsb, 18 with anti‐Coa, 11 and a patient with anti‐Rh17 19 . In the latter case, maternal blood was ABO incompatible with the fetus, and a good outcome was achieved.…”

Anti Colton-A Foeto-Neonatal Haemolytic Disesase: Diagnosis; Clinical Outcome and Family Study

“…In vivo studies have shown that anti-Co a and anti-Co b antibodies are able to reduce the survival of targeted erythrocytes [19][20][21][22][23]. There are also reports of auto-antibodies mimicking Colton specificities [24,25].…”