Anti-cholesterol activity test of tanjung (Mimusops elengi L.) leaf extract in the water using in vivo method in mice (Mus musculus L.) DDY-strain

Tristantini, Dewi; Pradana, Bhayangkara Tegar

doi:10.1063/1.4976778

Cited by 27 publications

(31 citation statements)

References 11 publications

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“…Table 2 summarizes the findings and can be found by clicking this link. The effective concentration of the extract that causes a loss of DPPH that is equivalent to fifty percent is what the IC50 value describes [28]. The IC50 value of the ethanolic extract of cinnamon bark was found to be 25.3567 ppm, while the IC50 value of vitamin C was found to be 3.1936 ppm in Table 3.…”

Section: Antioxidant Activity Test Resultsmentioning

confidence: 93%

Phytochemical Screening of Cinnamon Bark (Cinnamomum burmanii) (C. Ness & T. Ness) C. Ness ex Blume Ethanol Extract and Antioxidant Activity Test with DPPH (2,2-diphenyl-1-picrylhydrazyl) Method.

Sirait

Arianto

Dalimunthe

2023

International Journal of Science, Technology & Management

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Cinnamon (Cinnamomum burmanii) is one of the spices that can be used as cosmetic preparations in the pharmaceutical industry because it contains potent antioxidants. Examples of cosmetic products containing cinnamon are body scrubs, body showers, and moisturizers. This study aimed to determine the antioxidant activity of cinnamon extract using the DPPH method. Cinnamon was extracted using the maceration technique with 96% ethanol solvent, and phytochemical screening was carried out. The results of phytochemical screening from cinnamon bark extract were alkaloids, saponins, tannins, triterpenoids, and flavonoids. Antioxidant activity obtained an IC50 value of 25.35 ppm. Based on these results, the cinnamon extract has a very strong antioxidant activity value.

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Section: Antioxidant Activity Test Resultsmentioning

confidence: 93%

Phytochemical Screening of Cinnamon Bark (Cinnamomum burmanii) (C. Ness & T. Ness) C. Ness ex Blume Ethanol Extract and Antioxidant Activity Test with DPPH (2,2-diphenyl-1-picrylhydrazyl) Method.

Sirait

Arianto

Dalimunthe

2023

International Journal of Science, Technology & Management

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“…Quercetin, isorhamnetin, kaempferol, and myricetin are the most common flavonols found in foods. These flavonoid compounds exhibit antibacterial, antioxidant and anti-inflammatory properties in the body and have recently made huge significant progress as a factor related to decreasing the risk for Alzheimer's disease, which is gaining more public attention in countries with increasing aged populations (Tristantini and Pradana, 2017) (Huntington Lifestyle Partners, 2021). The obtained DPPH result (Table 3) showed the lowest IC 50 value observed in A. montanus acetone extract (132.7 ± 0.01 µg/mL) corresponding to the most active extract while the ethyl acetate and methanol extract (149.3 ± 0.00 µg/mL and 164.6 ± 0.01 µg/mL) gave a considerable IC 50 value.…”

Section: Effect Of Extraction Solvent On Total Flavonols Content Of Acanthus Montanus Leaf Extractsmentioning

confidence: 99%

Evaluation of different solvents for extraction of phytochemical constituents and antioxidant activities of the leaves of Acanthus montanus (Nees) T. Anderson

Enitan¹,

Oduola²,

Olorunyomi³

2021

Lekovite sirovine

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Bear's breech or mountain thistle (Acanthus montanus (Nees) T. Anderson) is a shrub belonging to Acanthaceae family. It is widespread in Africa, Romania, Greece, and Eastern Mediterranean. African people engage its medicinal use for the management of urethral pain, endometritis, urogenital infections, urinary disease, aches and pains. Fresh leaves of A. montanus were collected from Forestry Research Institute of Nigeria (FRIN) herbal garden and identified at the Forestry Herbarium, Ibadan. About 200 g of the powered sample was macerated in 400 mL each of three organic solvents such as ethyl acetate, acetone and methanol respectively, for 24 h. Each extracts were screened for phytochemicals such as flavonoids, saponins, phenols, terpenoids, phlobotannins, alkaloids, tannins, and cardiac glycosides. Estimation of total flavonol content, and antioxidant assays such as 2,2-diphenyl-1-picrylhydrazyl (DPPH) and nitric oxide radical scavenging activity were also carried out. The quantitative phytochemical test (flavonol content) revealed that Acanthus montanus methanol extract was the richest one among the solvent systems while acetone extract gave the best antioxidant activity. It was observed that the antioxidant activity could be attributed to moderately polar extracts. The study, therefore, provides evidence that various solvents used in extraction can result in differences in quantitative phytochemicals and antioxidant activity.

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“…Pharmacopoeia Indonesia [2] stated that vitamins A, C, E contained in watercress tend to be soluble in ethanol solvent, while compounds in the polyphenol group, such as flavonoids, according to Rahman et al [3] can be macerated using 70% ethanol which tends to be semipolar in water-ethanol combination [2,4]. Watercress contains isothiocynate compounds, kaempferol glycosides and l-tryptophan which functions to ward off free radicals, help repair damage and DNA synthesis [5].…”

Section: Introductionmentioning

confidence: 99%

“…The IC 50 value is the smallest concentration capable of inhibiting 50% of free radicals using a 2,2-diphenyl-1-picrylhydrazyl (DPPH) reagent. The lower the IC 50 value, the higher the antioxidant activity of the substance, meaning that it only requires a small concentration to inhibit free radicals by 50% [5], the antioxidant activity test of 70% ethanolic watercress extract is by produces an IC 50 value of 102.26 ppm [3].…”

Section: Introductionmentioning

confidence: 99%

Identification of Antioxidant Active Compounds from Watercress (Nasturtium officinale R.Br)

Bustanussalam¹,

Hapsari²,

Rachman³

et al. 2023

Proceedings of the 1st International Conference for Health Research – BRIN (ICHR 2022)

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Watercress (Nasturtium officinale R.Br) is a highlands plant that has been eaten as a vegetable by many people. Watercress contains protein, calcium, phosphorus, iron, vitamin A, vitamin E, vitamin C, flavonoids and phenols. Antioxidants are components that can delay or prevent the oxidation of lipids, nucleic acids, or other molecules by inhibiting the initiation or propagation of oxidation chain reactions. The function of antioxidants is to neutralize free radicals, so that the body is protected from various degenerative diseases and helps suppress the aging process. The purpose of this study was to isolate and identify antioxidant compounds in watercress. The studies included maceration and reflux extraction with 96% ethanol, partitioning (with n-hexane and ethyl acetate), antioxidant activity determination, and compound determination. Antioxidant activity test by 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenger method showed that the watercress ethyl acetate extract had the highest antioxidant activity with IC 50 of 67.77 ppm. Fractionation by first column chromatography [SiO 2 ; n-hexane: ethyl acetate (10:1-1:1), CHCl 3 : MeOH (15:1-1:1)] obtained 5 combined fractions (F1-F5) where the results of the antioxidant activity test of fraction 5 (F5) had a great inhibition value compared to other fractions of 61.04%. Furthermore, F5 fractionated second column chromatography [SiO 2 ; n-hexane: ethyl acetate (1:1), CHCl 3 : MeOH (5:1)] obtained 2 combined fractions (F5.1 and F5.2). After two purifications using column chromatography and testing for antioxidant activity, fraction 5.2 had the highest activity with an IC 50 value of 75.65 ppm. Fraction 5.2 contained phenols and/or flavonoids according to phytochemical screening, while UV-Vis, Fourier transform infrared (FTIR) spectrophotometry and gas chromatography-mass spectrometry (GC-MS) spectroscopic results indicated that, the active ingredient in fraction 5.2 is expected to be 2-methoxy-4-vinylphenol.

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Anti-cholesterol activity test of tanjung (Mimusops elengi L.) leaf extract in the water using in vivo method in mice (Mus musculus L.) DDY-strain

Cited by 27 publications

References 11 publications

Phytochemical Screening of Cinnamon Bark (Cinnamomum burmanii) (C. Ness & T. Ness) C. Ness ex Blume Ethanol Extract and Antioxidant Activity Test with DPPH (2,2-diphenyl-1-picrylhydrazyl) Method.

Phytochemical Screening of Cinnamon Bark (Cinnamomum burmanii) (C. Ness & T. Ness) C. Ness ex Blume Ethanol Extract and Antioxidant Activity Test with DPPH (2,2-diphenyl-1-picrylhydrazyl) Method.

Evaluation of different solvents for extraction of phytochemical constituents and antioxidant activities of the leaves of Acanthus montanus (Nees) T. Anderson

Identification of Antioxidant Active Compounds from Watercress (Nasturtium officinale R.Br)

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