Anti-CCP antibodies measured at disease onset help identify seronegative rheumatoid arthritis and predict radiological and functional outcome

Quinn, Mark; Gough, Andrew; Green, M. J.; Devlin, Joe; Hensor, Elizabeth M A; Greenstein, Adam; Fraser, Alexander; Emery, Paul

doi:10.1093/rheumatology/kei203

Cited by 124 publications

(93 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous studies have reported anti-CCP antibody positivities in about 34-60% of RFnegative RA patients (Lee and Schur 2003;Quinn et al 2005). Anti-CCP antibodies were positive in 26.3% of RF-negative RA patients in our study.…”

Section: Discussionsupporting

confidence: 56%

“…However, although RF has little diagnostic utility, its place has been retained in practice because of its prognostic ability and the lack of alternative tests (Quinn et al 2005). It is known as a nonspecifi c marker, since it may also be detected in patients with other autoimmune and infectious diseases and even in healthy persons.…”

Section: Participants and Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Anti-Cyclic Citrullinated Peptide Antibodies in Rheumatoid Arthritis and Behcet's Disease

Koca

Akbulut

Dag

et al. 2007

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 56%

Section: Participants and Methodsmentioning

confidence: 99%

Anti-Cyclic Citrullinated Peptide Antibodies in Rheumatoid Arthritis and Behcet's Disease

Koca

Akbulut

Dag

et al. 2007

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

“…T he production of autoantibodies against citrullinated protein Ags (ACPA) is a unique marker for rheumatoid arthritis (RA) (1)(2)(3)(4)(5)(6). These Abs are present in the majority of RA patients, are virtually never observed in healthy people, and are only rarely found in persons with other conditions (7).…”

mentioning

confidence: 99%

Production of Autoantibodies against Citrullinated Antigens/Peptides by Human B Cells

Bellatin

Han

Fallena

et al. 2012

The Journal of Immunology

View full text Add to dashboard Cite

Autoantibodies against citrullinated protein Ags (ACPA) are associated with the development of rheumatoid arthritis (RA). This immune response against citrullinated protein Ags, which is thought to be facilitated by certain MHC HLA-DR alleles, is highly specific for this disease and has been speculated to be involved in the pathogenesis. We have previously studied cultures of B cells for the production of Abs against HLA Ags. The aim of the current study was to examine the role of B cells in the production of ACPA in patients with RA. Peripheral blood B cells from RA patients and healthy people were cultured with EL4-B5, a murine cell line expressing human CD40L, and with T cell factors to stimulate the in vitro production of Abs by B cells isolated from peripheral blood. ACPA were produced by cultured B cells from RA patients, as determined by reactivity to cyclic citrullinated peptide (CCP). The results showed that 22% of the healthy persons tested also had B cells that could produce ACPA. Patients with HLA-DR alleles carrying the RA-associated shared epitope appeared to have more B cells with autoimmune potential for CCP than those without such HLA alleles (odds ratio 8.1, p = 0.001). In healthy individuals, anti-CCP–producing B cells were also observed more frequently if the RA-associated MHC genes were present (odds ratio 8.0, p = 0.01). Analysis of B cells in cultures may shed light on the interaction of genetic and environmental factors in the development of RA.

show abstract

“…21,22 According to some authors, CCP2 seems to be as sensitive as RF IgM and more specifi c. Its advantage is to detect antibodies in approximately 15% of RA patients who are negative for RF. [23][24][25][26][27][28][29][30][31] However, Nishimura et al, 8 in their meta-analysis about anti-CCP and RF accuracy for RA, have concluded that isolated positivity for anti-CCP is more specifi c than isolated positivity for RF IgM in the RA diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, in isolation, CCP2, CCP3 and CCP3.1 showed, in our study, anti-CCP prevalence below that of RF IgM and similar to that of RF IgA, which differs from many studies previously reported. [23][24][25][26][27][28][29][30][31] The sensitivity, specifi city and cost-benefi t difference between the three techniques to detect anti-CCP is still a controversial subject in the literature, requiring further studies in different populations. 32 In 2005, a third generation of anti-CCP (CCP3) was made available for RA laboratory diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Autoanticorpos na artrite reumatoide inicial: coorte Brasília - resultados de uma análise seriada de três anos

Mota¹,

Neto

Pereira³

et al. 2011

Rev. Bras. Reumatol.

View full text Add to dashboard Cite

The diagnostic and prognostic value of the serial measurement of antibodies, such as rheumatoid factor (RF), anti-cyclic citrullinated peptide (anti-CCP), and anti-citrullinated vimentin (anti-Sa) antibodies, has not been defi ned in early rheumatoid arthritis (ERA). Objectives: To prospectively assess the presence of RF, anti-CCP, and anti-Sa in ERA patients. Patients and methods: Forty ERA (less than 12 months) patients of the Brasília cohort were evaluated and followed up for three years. Both clinical and demographic data were recorded, in addition to the results (ELISA) of RF (IgM, IgG, and IgA), anti-CCP (CCP2, CCP3, and CCP3.1), and anti-Sa at the baseline assessment and after 3, 6, 12, 18, 24 and 36 months of follow-up. The results were compared by use of Student t test and paired t test. Results: The patients' mean age was 45 years, and 90% of them were female. At the time of diagnosis, RF was identifi ed in 50% of the patients (RF IgA, 42%; RF IgG, 30%; and RF IgM, 50%), anti-CCP in 52.5% (no difference between CCP2, CCP3, and CCP3.1), and anti-Sa in 10%. After three years, no difference was observed in RF and anti-CCP prevalence, but anti-Sa increased to 17.5% (P = 0.001). Conclusion: Repeated RF and anti-CCP measurement, including different isotypes, during three years of follow-up showed no signifi cant changes. The third generation of anti-CCP assays did not increase the diagnostic value of the second-generation assays.

show abstract

Anti-CCP antibodies measured at disease onset help identify seronegative rheumatoid arthritis and predict radiological and functional outcome

Abstract: This study confirms the diagnostic utility of anti-CCP(2) antibodies in early RA, particularly in seronegative patients, in whom anti-CCP(2) positivity also conferred prognostic utility for radiographic and functional outcomes.

Cited by 124 publications

References 18 publications

Anti-Cyclic Citrullinated Peptide Antibodies in Rheumatoid Arthritis and Behcet's Disease

Anti-Cyclic Citrullinated Peptide Antibodies in Rheumatoid Arthritis and Behcet's Disease

Production of Autoantibodies against Citrullinated Antigens/Peptides by Human B Cells

Autoanticorpos na artrite reumatoide inicial: coorte Brasília - resultados de uma análise seriada de três anos

Contact Info

Product

Resources

About