Anti-Candidal Activity of the Parasitic Plant Orobanche crenata Forssk

D’Angeli, Floriana; Guadagni, Fiorella; Genovese, Carlo; Nicolosi, Daria; Salinaro, Angela Trovato; Spampinato, Mariarita; Mannino, Giuliana; Furno, Debora Lo; Petronio, Giulio Petronio; Ronsisvalle, Simone; Sipala, Federica; Falzone, Luca; Calabrese, Vittorio

doi:10.3390/antibiotics10111373

Cited by 6 publications

(3 citation statements)

References 114 publications

(127 reference statements)

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“…Orobanche crenata (OCLE), a parasitic plant particularly widespread in the Mediterranean area, has shown the ability to inhibit the growth of numerous bacteria and Candida spp. [ 94 ]. D’Angeli et al have shown that OCLE can inhibit the growth of C. albicans and C. glabrata but does not cause death (it has a fungistatic effect).…”

Section: Novel Strategies To Control Biofilm-associated Ocular Infect...mentioning

confidence: 99%

“…Nanosystems and alternative compounds for the treatment of fungal infections.Research and development of new drugs is aimed at the study of phytoextracts, which contain a pool of bioactive compounds with different biological activities, including antimicrobial ones. It has been shown that phenolic compounds, isolated from natural sources, have shown anticandidal activity, even if knowledge on the biological properties of various medicinal plants remains limited.Orobanche crenata (OCLE), a parasitic plant particularly widespread in the Mediterranean area, has shown the ability to inhibit the growth of numerous bacteria and Candida spp [94]…”

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confidence: 99%

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Candida Biofilm Eye Infection: Main Aspects and Advance in Novel Agents as Potential Source of Treatment

et al. 2023

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Fungi represent a very important cause of microbial eye infections, especially in tropical and developing countries, as they could cause sight-threating disease, such as keratitis and ocular candidiasis, resulting in irreversible vision loss. Candida species are among the most frequent microorganisms associated with fungal infection. Although Candida albicans is still the most frequently detected organism among Candida subspecies, an important increase in non-albicans species has been reported. Mycotic infections often represent an important diagnostic-clinical problem due to the difficulties in performing the diagnosis and a therapeutic problem due to the limited availability of commercial drugs and the difficult penetration of antifungals into ocular tissues. The ability to form biofilms is another feature that makes Candida a dangerous pathogen. In this review, a summary of the state-of-the-art panorama about candida ocular pathology, diagnosis, and treatment has been conducted. Moreover, we also focused on new prospective natural compounds, including nanoparticles, micelles, and nanocarriers, as promising drug delivery systems to better cure ocular fungal and biofilm-related infections. The effect of the drug combination has also been examined from the perspective of increasing efficacy and improving the course of infections caused by Candida which are difficult to fight.

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Section: Novel Strategies To Control Biofilm-associated Ocular Infect...mentioning

confidence: 99%

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confidence: 99%

Candida Biofilm Eye Infection: Main Aspects and Advance in Novel Agents as Potential Source of Treatment

et al. 2023

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“…The elution rate was 300 µL/min for 30 min into a C18 column (Phenomenex Kinetex ® 2.6 µm C18 100 Å, 100 × 2.1 mm, with a volume of injection of 10 µL. To comprehensively assess the analyzed spectrum, ESI-Ms/Ms was used with positive and negative polarities for detailed spectrum analysis, with the equipment settings as previously reported [57]. To quantify the crocin content in each variety of saffron, crocin was properly diluted in water and the calibration curve was constructed in the range 8000 ng/mL-150,000 ng/mL using the software's "Quantitation Wizard" function.…”

Section: Determination Of Crocin Contentmentioning

confidence: 99%

Evaluation of Crocin Content and In Vitro Antioxidant and Anti-Glycation Activity of Different Saffron Extracts

Ronsisvalle,

Panico,

Santonocito

et al. 2023

Plants

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Crocin, a glycoside carotenoid that exhibits several health benefits, is mainly obtained from saffron (Crocus sativus L.), whose quality and content of phytochemicals can be strongly affected by environmental conditions. Therefore, in this work, the crocin content and in vitro antioxidant activity of saffron extracts obtained from three different varieties (Greek, Sicilian, and Iranian saffron) were assessed. Crocin content in saffron extracts was quantified via ultra-performance liquid chromatography coupled with mass spectrometry. The antioxidant activity of saffron extracts was evaluated using the oxygen radical absorbance capacity (ORAC) assay and nitric oxide (NO) radical scavenging test. The Maillard reaction was used to assess anti-glycation activity. Although the Sicilian and Iranian saffron extracts contained higher amounts of crocin (128 ± 6 ng/mL and 126 ± 4 ng/mL, respectively) compared to the Greek extracts (111 ± 2 ng/mL), ORAC values (50.9 ± 0.5) and % NO inhibition (35.2 ± 0.2) were higher for the Greek variety, which displayed a total phenolic content about two-fold greater than that of the other two extracts. Sicilian and Greek saffron had similar anti-glycation activities, while Iranian saffron was less effective. These results suggest that the antioxidant activity of saffron extracts could be ascribed to their naturally occurring complex mixture of phytochemicals, deserving further investigation as supplements to prevent pathological conditions induced by radical species.

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Recent developments in parasitic plant biology

Stanga

2022

CABI Reviews

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Parasitic plants are taxonomically diverse, globally distributed, and capable of parasitizing a wide array of host plants, often with preferences for specific hosts. Some parasitic plants are damaging pests of numerous crops; their effects can be especially detrimental in low-input agriculture. Effective breeding and management strategies rely on comprehensive information about the life history, evolution, genetics, biochemistry, physiology, communication, and ecology of parasitic plants and their hosts. High-throughput sequencing approaches are used to advance research in genome evolution, to identify genetic loci for breeding, to characterize microbial communities associated with parasitic plants, and to discover molecular mechanisms of parasitism and host responses. Molecular and biochemical investigations are elucidating the mechanisms by which parasitic seeds germinate in response to host phytohormones in the rhizosphere. Structural information guides synthesis- and screening-based methods to identify chemicals that could be used to promote or inhibit parasitic seed germination. Microbial communities in the rhizosphere influence parasitic plants and hosts as a system; fungal and bacterial species themselves, and products derived from them, have the potential for agronomic application. Proteins and nucleic acids exchanged through the haustorium reveal the complex interplay between parasitic plant pathogenesis and host defense responses. This review focuses on the latest developments published within the last two years.

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Anti-Candidal Activity of the Parasitic Plant Orobanche crenata Forssk

Cited by 6 publications

References 114 publications

Candida Biofilm Eye Infection: Main Aspects and Advance in Novel Agents as Potential Source of Treatment

Candida Biofilm Eye Infection: Main Aspects and Advance in Novel Agents as Potential Source of Treatment

Evaluation of Crocin Content and In Vitro Antioxidant and Anti-Glycation Activity of Different Saffron Extracts

Recent developments in parasitic plant biology

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