Anti-Candida Activity of Bursera morelensis Ramirez Essential Oil and Two Compounds, α-Pinene and γ-Terpinene—An In Vitro Study

Rivera-Yañez, Claudia Rebeca; Terrazas, Luis I.; Jiménez-Estrada, Manuel; Campos, Jorge E.; Flores-Ortíz, César Mateo; Hernandez, Luis Barbo; Cruz-Sanchez, Tonatiuh; Fariña, Germán Isauro Garrido; Rodríguez-Monroy, Marco Aurelio; Canales-Martínez, María Margarita

doi:10.3390/molecules22122095

Cited by 42 publications

(33 citation statements)

References 41 publications

(54 reference statements)

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“…Our results showed that both EO treatments had the better structure of scar tissue and a greater deposit of collagen. The antibacterial and antifungal activity of the EO of B. morelensis might be partly responsible for the results shown here because due to its lipophilic characteristics, the EO permeates the plasma membranes of both bacteria and fungi, generating ionic imbalances in membrane potential and even mitochondrial respiration, causing cellular collapse [9]. In our working group, it has been shown that the B. morelensis' EO alters the expression of the gene that codifies the integrin INT1p.…”

Section: Discussionmentioning

confidence: 72%

“…In our working group, it has been shown that the B. morelensis' EO alters the expression of the gene that codifies the integrin INT1p. This is very important since the integrins are known to be key in the adhesion of Candida albican; furthermore, EO inhibits the growth of the germ tube and causes the loss of the integrity of the cell membrane of this yeast [10].…”

Section: Discussionmentioning

confidence: 99%

“…The people of San Rafael, Coxcatlan (Puebla, Mexico) make a tea with the bark of this species to wash the wound. It has been verified that the essential oil (EO) of this species has antibacterial and antifungal activity [9,10] and also acts as an anti-inflammatory [8].…”

Section: Introductionmentioning

confidence: 99%

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Wound Healing Activity of the Essential Oil of Bursera morelensis, in Mice

et al. 2020

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Bursera morelensis is used in Mexican folk medicine to treat wounds on the skin. It is an endemic tree known as “aceitillo”, and the antibacterial and antifungal activity of its essential oil has been verified; it also acts as an anti-inflammatory. All of these reported biological activities make the essential oil of B. morelensis a candidate to accelerate the wound-healing process. The objective was to determine the wound-healing properties of B. morelensis’ essential oil on a murine model. The essential oil was obtained by hydro-distillation, and the chemical analysis was performed by gas chromatography-mass spectrometry (GC-MS). In the murine model, wound-healing efficacy (WHE) and wound contraction (WC) were evaluated. Cytotoxic activity was evaluated in vitro using peritoneal macrophages from BALB/c mice. The results showed that 18 terpenoid-type compounds were identified in the essential oil. The essential oil had remarkable WHE regardless of the dose and accelerated WC and was not cytotoxic. In vitro tests with fibroblasts showed that cell viability was dose-dependent; by adding 1 mg/mL of essential oil (EO) to the culture medium, cell viability decreased below 80%, while, at doses of 0.1 and 0.01 mg/mL, it remained around 90%; thus, EO did not intervene in fibroblast proliferation, but it did influence fibroblast migration when wound-like was done in monolayer cultures. The results of this study demonstrated that the essential oil was a pro-wound-healing agent because it had good healing effectiveness with scars with good tensile strength and accelerated repair. The probable mechanism of action of the EO of B. morelensis, during the healing process, is the promotion of the migration of fibroblasts to the site of the wound, making them active in the production of collagen and promoting the remodeling of this collagen.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

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Wound Healing Activity of the Essential Oil of Bursera morelensis, in Mice

et al. 2020

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“…Rich in these substances are, among others Origanum and Thymus plants. Important antifungal chemicals often presented in Lamiaceae are also other monoterpenes as alcohol linalool and cyclic 1,8-cineole, limonene, pinenes, and terpinenes [138][139][140][141][142][143][144][145][146]. Table 1 shows that all of these antifungal substances are common in presented plants.…”

Section: Essential Oil Main Chemical Componentsmentioning

confidence: 99%

Essential Oils of Lamiaceae Family Plants as Antifungals

Karpiński

2020

Biomolecules

125

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The incidence of fungal infections has been steadily increasing in recent years. Systemic mycoses are characterized by the highest mortality. At the same time, the frequency of infections caused by drug-resistant strains and new pathogens e.g., Candida auris increases. An alternative to medicines may be essential oils, which can have a broad antimicrobial spectrum. Rich in the essential oils are plants from the Lamiaceae family. In this review are presented antifungal activities of essential oils from 72 Lamiaceae plants. More than half of these have good activity (minimum inhibitory concentrations (MICs) < 1000 µg/mL) against fungi. The best activity (MICs < 100) have essential oils from some species of the genera Clinopodium, Lavandula, Mentha, Thymbra, and Thymus. In some cases were observed significant discrepancies between different studies. In the review are also shown the most important compounds of described essential oils. To the chemical components most commonly found as the main ingredients include β-caryophyllene (41 plants), linalool (27 plants), limonene (26), β-pinene (25), 1,8-cineole (22), carvacrol (21), α-pinene (21), p-cymene (20), γ-terpinene (20), and thymol (20).

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“…The alteration of cell permeability caused by the insertion of small molecules of monoterpenes between the fatty acid chains of membrane phospholipids seems to be a common effect [ 123 , 124 ]. A high inhibitory activity was related to the presence of an aromatic ring in the monoterpene molecule [ 125 ], and thymol and carvacrol have been the subject of several investigations aimed at unravelling their mechanism of action. This involves the inhibition of ergosterol biosynthesis, with disruption of membrane integrity [ 126 ].…”

Section: Anti- Candida Activitymentioning

confidence: 99%

Anti-Candida Activity of Essential Oils from Lamiaceae Plants from the Mediterranean Area and the Middle East

et al. 2020

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Extensive documentation is available on plant essential oils as a potential source of antimicrobials, including natural drugs against Candida spp. Yeasts of the genus Candida are responsible for various clinical manifestations, from mucocutaneous overgrowth to bloodstream infections, whose incidence and mortality rates are increasing because of the expanding population of immunocompromised patients. In the last decade, although C. albicans is still regarded as the most common species, epidemiological data reveal that the global distribution of Candida spp. has changed, and non-albicans species of Candida are being increasingly isolated worldwide. The present study aimed to review the anti-Candida activity of essential oils collected from 100 species of the Lamiaceae family growing in the Mediterranean area and the Middle East. An overview is given on the most promising essential oils and constituents inhibiting Candida spp. growth, with a particular focus for those natural products able to reduce the expression of virulence factors, such as yeast-hyphal transition and biofilm formation. Based on current knowledge on members of the Lamiaceae family, future recommendations to strengthen the value of these essential oils as antimicrobial agents include pathogen selection, with an extension towards the new emerging Candida spp. and toxicological screening, as it cannot be taken for granted that plant-derived products are void of potential toxic and/or carcinogenic properties.

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Anti-Candida Activity of Bursera morelensis Ramirez Essential Oil and Two Compounds, α-Pinene and γ-Terpinene—An In Vitro Study

Cited by 42 publications

References 41 publications

Wound Healing Activity of the Essential Oil of Bursera morelensis, in Mice

Wound Healing Activity of the Essential Oil of Bursera morelensis, in Mice

Essential Oils of Lamiaceae Family Plants as Antifungals

Anti-Candida Activity of Essential Oils from Lamiaceae Plants from the Mediterranean Area and the Middle East

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