Anti-cancer studies of noble metal nanoparticles synthesized using different plant extracts

Abstract

Biofunctionalized gold and silver nanoparticles synthesized using different plant extracts of guava and clove in vitro anti-cancer efficacy against four different cancer cell lines human colorectal adenocarcinoma, human kidney, human chronic myelogenous, leukemia, bone marrow, and human cervix have been studied and reported. The present experimental study suggests that flavonoids functionalized gold nanoparticles synthesized using aqueous clove buds extract are more potential than guava leaf extract towards anti-cancer activities. The microscopic and 2,3-bis (2-methoxy-4-nitro-5-sulfophenyl)-5-[(phenylamino)carbonyl]-2H-tetrazolium hydroxide (XTT) assay infer that the functionalized irregular shaped gold nanoparticles synthesized with aqueous clove bud extract showed a satisfactory anti-cancer effect on all the cell lines. The silver nanoparticles synthesized using same extracts are devoid of anti-cancer activity. The XTT assay revealed dose-dependent cytotoxicity to cancer cell lines. The study revealed that the free radicals generated by gold nanoparticles are responsible for anti-cancer effect. To confirm the free-radical scavenging efficacy of gold nanoparticle, nitric oxide assay is followed. We observed that the gold nanoparticles swabbed the free radicals in dose-dependent manner. With continued improvements, these nanoparticles may prove to be potential anti-cancer agents.

Eco-Friendly Synthesis and Antimicrobial Activity of Silver Nanoparticles Using Dracocephalum moldavica Seed Extract

“…A similar trend is observed in the synthesis of AgNPs using Artocarpus heterophyllus Lam. [39] and Abelmoschus esculentus [33] seed extracts. The size and morphology of synthesized AgNPs were determined by TEM images, as shown in Figure 5.…”

Cytotoxicity in MCF-7 and MDA-MB-231 Breast Cancer Cells, without Harming MCF-10A Healthy Cells

“…Several researchers agree that this exploration creates an avenue to a new standard where the different functionalized gold nanoparticles can be a powerful weapon against cancer [18]. The use of various nanoparticles to deliver genetic, medicinal, or other materials into cells is a leading trend in current nanobiotechnology coupled with its biomedical applications.…”

Antimicrobial and Anticancer Activity of Silver Nanoparticles From Edible Mushroom: A Review

“…Nanoparticles will have a lethal effect on the cell wall of the cancer cells [33]. Water soluble organic moieties in the nanoparticles induce a synergistic antiproliferative effect in various cancer cell lines, thus prove to be useful in various types of cancer control system (Fig.…”