Anti-Cancer Roles of Probiotic-Derived P8 Protein in Colorectal Cancer Cell Line DLD-1

An, Byung Chull; Ahn, Jun Young; Kwon, Daebeom; Kwak, Sang Hee; Heo, Jun-Haeng; Kim, Seungwoo; Ryu, Yongku; Chung, Myung Jun

doi:10.3390/ijms24129857

Cited by 6 publications

(4 citation statements)

References 43 publications

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“…demonstrate an antiproliferative effect linked to a lower expression of cyclin D1 [ 280 ]. The probiotic-derived p8 protein exhibits antiproliferative activity by inhibiting the p53-p21-Cyclin B1/Cdk1 signal pathway, leading to growth arrest at the G2 phase of the cell cycle in human colorectal DLD-1 cells [ 281 ]. Exopolysaccharides derived from L. acidophilus 606 inhibit the proliferation of HT-29 colon cancer cells by directly affecting cell morphology and activating autophagic cell death through the induction of Bcl-2, Bak, Beclin-1, and GRP78 [ 282 ].…”

Section: Antiviral Antibacterial Antioxidants Anticancer and Anti-inf...mentioning

confidence: 99%

Postbiotics: Functional Food Materials and Therapeutic Agents for Cancer, Diabetes, and Inflammatory Diseases

Gurunathan,

Thangaraj,

Kim

2023

Foods

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Postbiotics are (i) “soluble factors secreted by live bacteria, or released after bacterial lysis, such as enzymes, peptides, teichoic acids, peptidoglycan-derived muropeptides, polysaccharides, cell-surface proteins and organic acids”; (ii) “non-viable metabolites produced by microorganisms that exert biological effects on the hosts”; and (iii) “compounds produced by microorganisms, released from food components or microbial constituents, including non-viable cells that, when administered in adequate amounts, promote health and wellbeing”. A probiotic- and prebiotic-rich diet ensures an adequate supply of these vital nutrients. During the anaerobic fermentation of organic nutrients, such as prebiotics, postbiotics act as a benevolent bioactive molecule matrix. Postbiotics can be used as functional components in the food industry by offering a number of advantages, such as being added to foods that are harmful to probiotic survival. Postbiotic supplements have grown in popularity in the food, cosmetic, and healthcare industries because of their numerous health advantages. Their classification depends on various factors, including the type of microorganism, structural composition, and physiological functions. This review offers a succinct introduction to postbiotics while discussing their salient features and classification, production, purification, characterization, biological functions, and applications in the food industry. Furthermore, their therapeutic mechanisms as antibacterial, antiviral, antioxidant, anticancer, anti-diabetic, and anti-inflammatory agents are elucidated.

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Section: Antiviral Antibacterial Antioxidants Anticancer and Anti-inf...mentioning

confidence: 99%

Postbiotics: Functional Food Materials and Therapeutic Agents for Cancer, Diabetes, and Inflammatory Diseases

Gurunathan,

Thangaraj,

Kim

2023

Foods

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“…Probiotic-derived ferrichrome acts as a tumor-suppressive molecule via the c-Jun N-terminal kinase (JNK) signaling pathway against cancerous IECs to a greater extent than conventional chemotherapeutic drugs, including cisplatin and 5-FU [223]. The probiotic-derived P8 protein was found to eliminate metastasis [224] and suppress CRC growth via the inhibition of the Wnt signaling pathway [225], whereas mucin binding protein (MucBP) exhibits dose-dependent antiproliferative effects against HT-29 cells [226]. ↓ cell proliferation, extrinsic and intrinsic apoptosis induction, ↑ FasR and TRAILR1 expression (m2163)/ ↑ FasR, TNFR1, and TRAILR1 (m2386) [221] Mixirins (Bacillus sp.…”

Section: Other Bacterial Peptidesmentioning

confidence: 99%

“…antiproliferative and anti-migration activity, cell cycle arrest (G2), p53-p21-Cyclin B1/CDK1 pathway inhibition [224] Wnt pathway suppression (dysregulation of GSK3β transcription), cell cycle arrest [225] ↑: increase or up-regulation, ↓:…”

Section: Other Bacterial Peptidesmentioning

confidence: 99%

Probiotic-Derived Bioactive Compounds in Colorectal Cancer Treatment

Thoda

Touraki

2023

Microorganisms

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Colorectal cancer (CRC) is a multifactorial disease with increased morbidity and mortality rates globally. Despite advanced chemotherapeutic approaches for the treatment of CRC, low survival rates due to the regular occurrence of drug resistance and deleterious side effects render the need for alternative anticancer agents imperative. Accumulating evidence supports that gut microbiota imbalance precedes the establishment of carcinogenesis, subsequently contributing to cancer progression and response to anticancer therapy. Manipulation of the gut microbiota composition via the administration of probiotic-derived bioactive compounds has gradually attained the interest of scientific communities as a novel therapeutic strategy for CRC. These compounds encompass miscellaneous metabolic secreted products of probiotics, including bacteriocins, short-chain fatty acids (SCFAs), lactate, exopolysaccharides (EPSs), biosurfactants, and bacterial peptides, with profound anti-inflammatory and antiproliferative properties. This review provides a classification of postbiotic types and a comprehensive summary of the current state of research on their biological role against CRC. It also describes how their intricate interaction with the gut microbiota regulates the proper function of the intestinal barrier, thus eliminating gut dysbiosis and CRC development. Finally, it discusses the future perspectives in precision-medicine approaches as well as the challenges of their synthesis and optimization of administration in clinical studies.

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“…P8 could also bind directly to and inhibit glycogen synthase kinase-3 beta (GSK3β), which is a key protein kinase trigger degradation of β-catenin in Wnt signaling. [ 50 ] The direct probiotic effects in anti-proliferation and apoptotic induction might be a key to decelerate adenoma progression to CRC.…”

Section: Mechanisms Of Probiotics In Crc Prevention and Treatmentmentioning

confidence: 99%

Probiotics intervention in colorectal cancer: From traditional approaches to novel strategies

Ha,

Zhang,

2023

Chin Med J

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The intestine harbors a large population of microorganisms that interact with epithelial cells to maintain host healthy physiological status. These intestinal microbiota engage in the fermentation of non-digestible nutrients and produce beneficial metabolites to regulate host homeostasis, metabolism, and immune response. The disruption of microbiota, known as dysbiosis, has been implicated in many intestinal diseases, including colorectal cancer (CRC). As the third most common cancer and the second leading cause of cancer-related death worldwide, CRC poses a significant health burden. There is an urgent need for novel interventions to reduce CRC incidence and improve clinical outcomes. Modulating the intestinal microbiota has emerged as a promising approach for CRC prevention and treatment. Current research efforts in CRC probiotics primarily focus on reducing the incidence of CRC, alleviating treatment-related side effects, and potentiating the efficacy of anticancer therapy, which is the key to successful translation to clinical practice. This paper aims to review the traditional probiotics and new interventions, such as next-generation probiotics and postbiotics, in the context of CRC. The underlying mechanisms of probiotic anti-cancer effects are also discussed, including the restoration of microbial composition, reinforcement of gut barrier integrity, induction of cancer cell apoptosis, inactivation of carcinogens, and modulation of host immune response. This paper further evaluates the novel strategy of probiotics as an adjuvant therapy in boosting the efficacy of chemotherapy and immunotherapy. Despite all the promising findings presented in studies, the evaluation of potential risks, optimization of delivery methods, and consideration of intra-patient variability of gut microbial baseline must be thoroughly interpreted before bench-to-bedside translation.

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Anti-Cancer Roles of Probiotic-Derived P8 Protein in Colorectal Cancer Cell Line DLD-1

Cited by 6 publications

References 43 publications

Postbiotics: Functional Food Materials and Therapeutic Agents for Cancer, Diabetes, and Inflammatory Diseases

Postbiotics: Functional Food Materials and Therapeutic Agents for Cancer, Diabetes, and Inflammatory Diseases

Probiotic-Derived Bioactive Compounds in Colorectal Cancer Treatment

Probiotics intervention in colorectal cancer: From traditional approaches to novel strategies

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