Anti-cancer Properties of Potential Probiotics and Their Cell-free Supernatants for the Prevention of Colorectal Cancer: an In Vitro Study

Pahumunto, Nuntiya; Teanpaisan, Rawee

doi:10.1007/s12602-022-09972-y

Cited by 12 publications

(12 citation statements)

References 43 publications

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“…In addition, to achieve the health benefits of probiotic strains in vivo, the other factors should be considered, especially probiotic survival in the gastrointestinal tract (GIT). The abilities to tolerate acid and bile salts of the probiotic strains used in the present study have been proven in previous reports [ 59 ]. However, some other factors, such as carrier matrices, sensory properties, shelf life, etc., should be considered [ 60 ] for the achievement of desirable health benefits.…”

Section: Discussionsupporting

confidence: 63%

Characterization of Short Chain Fatty Acids Produced by Selected Potential Probiotic Lactobacillus Strains

2022

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Short-chain fatty acids (SCFAs), particularly butyrate, have received considerable attention with regard to their anti-cancer efficacy in delaying or preventing colorectal cancer. Several studies have reported that certain probiotic strains could produce SCFAs; however, different strains yielded different amounts of SCFAs. This study explored the ability to produce SCFAs of the following probiotic strains: Lacticaseibacillus paracasei SD1, Lacticaseibacillus rhamnosus SD4, Lacticaseibacillus rhamnosus SD11, and Lacticaseibacillus rhamnosus GG. L. paracasei SD1 and L. rhamnosus SD11 exhibited high butyrate production, particularly when the strains were combined. The functions of the SCFAs were further characterized; the SCFAs exerted a positive anti-cancer effect in the colon via various actions, including inhibiting the growth of the pathogens related to colon cancer, such as Fusobacterium nucleatum and Porphyromonas gingivalis; suppressing the growth of cancer cells; and stimulating the production of the anti-inflammatory cytokine IL-10 and antimicrobial peptides, especially human β-defensin-2. In addition, the SCFAs suppressed pathogen-stimulated pro-inflammatory cytokines, especially IL-8. The results of this study indicated that selected probiotic strains, particularly L. paracasei SD1 in combination with L. rhamnosus SD11, may serve as good natural sources of bio-butyrate, which may be used as biotherapy for preventing or delaying the progression of colon cancer.

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Section: Discussionsupporting

confidence: 63%

Characterization of Short Chain Fatty Acids Produced by Selected Potential Probiotic Lactobacillus Strains

2022

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“…Besides, the mRNA levels of apoptosis markers were dramatically induced after treating with LCFS in 3D system (63). Pahumunto et al showed that CFS of Lacticaseibacillus paracasei SD1, Lacticaseibacillus rhamnosus SD4, Lacticaseibacillus rhamnosus SD11, and Lacticaseibacillus rhamnosus GG could inhibit pro-inflammatory cytokine expression in Caco-2 cells and inhibit the growth of Caco-2 cells, supporting its role in preventing CRC (16).…”

Section: Cell-free Supernatant (Cfs)mentioning

confidence: 99%

“…Oral administration of heat-killed L. plantarum L-137 could enhance protection against IFV infection together with increased IFN-β production in the serum of infected mice at an early stage of infection (47). Lactobacillus rhamnosus GG (LGG) could ameliorate intestinal inflammation, and promote cytoprotective responses in the developing murine gut, thus playing a role in inflammatory bowel disease treatment (16,48,49). Li et al found the heat-killed LGG could also decrease lipopolysaccharide (LPS)-induced proinflammatory mediators and increase anti-inflammatory mediators (50).…”

Section: Figurementioning

confidence: 99%

“…Here we mainly focus on the cell-free supernatant of bacteria, which are prepared after the bacterial cells were incubated, centrifuged, and removed (34). CFS has been reported to show antimicrobial, antioxidant, and antitumor activity (16,(58)(59)(60)(61)(62)(63).…”

Section: Cell-free Supernatant (Cfs)mentioning

confidence: 99%

“…Dietary patterns are considered as another critical factor in regulating gut microbiota homeostasis, which is detrimental for both initiation and progression of CRC (12)(13)(14)(15). Inflammation, especially chronic inflammation, plays an important role in CRC development, as revealed by the fact that patients with inflammatory bowel disease (IBD) have higher risks of CRC ranging from 8.3 to 18.4% (16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

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Beneficial insights into postbiotics against colorectal cancer

Song

Wang

et al. 2023

Front. Nutr.

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Colorectal cancer (CRC) is one of the most prevalent and life-threatening cancer types with limited therapeutic options worldwide. Gut microbiota has been recognized as the pivotal determinant in maintaining gastrointestinal (GI) tract homeostasis, while dysbiosis of gut microbiota contributes to CRC development. Recently, the beneficial role of postbiotics, a new concept in describing microorganism derived substances, in CRC has been uncovered by various studies. However, a comprehensive characterization of the molecular identity, mechanism of action, or routes of administration of postbiotics, particularly their role in CRC, is still lacking. In this review, we outline the current state of research toward the beneficial effects of gut microbiota derived postbiotics against CRC, which will represent the key elements of future precision-medicine approaches in the development of novel therapeutic strategies targeting gut microbiota to improve treatment outcomes in CRC.

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A Self‐Adaptive Pyroptosis Inducer: Optimizing the Catalytic Microenvironment of Nanozymes by Membrane‐Adhered Microbe Enables Potent Cancer Immunotherapy

Wang,

Zhang,

Zhang

et al. 2024

Advanced Materials

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Pyroptosis has garnered increasing attention in cancer immunotherapy. Moreover, increasing plasma membrane damage by reactive oxygen species (ROS) is considered an effective strategy for promoting pyroptosis. However, the current tactics for enhancing membrane rupture in pyroptosis are limited by the inherent drawbacks of ROS and the immunosuppressive tumor microenvironment. Herein, a self‐adaptive pyroptosis inducer (LPZ) is designed by integrating Lactobacillus rhamnosus GG (LGG) and an enzyme‐like metal‐organic framework to achieve potent pyroptosis immunotherapy. LPZ can adhere to cancer cell membranes through the interaction between the pili of LGG and the mucin of cancer cells. In particular, the adaptive formula can gradually enhance the ability of nanozymes to produce ROS by creating an acidic microenvironment through anaerobic respiration. These results verify that LPZ could generate high levels of ROS both on the membrane and within cancer cells, leading to pyroptotic cell death and strong antitumor immunity. Meanwhile, LGG are eventually killed by ROS in this process to halt their respiration and prevent potential biosafety concerns. Overall, this work provides new inspiration for the design of self‐adaptive nanocatalytic drugs for cancer immunotherapy.

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Anti-cancer Properties of Potential Probiotics and Their Cell-free Supernatants for the Prevention of Colorectal Cancer: an In Vitro Study

Cited by 12 publications

References 43 publications

Characterization of Short Chain Fatty Acids Produced by Selected Potential Probiotic Lactobacillus Strains

Characterization of Short Chain Fatty Acids Produced by Selected Potential Probiotic Lactobacillus Strains

Beneficial insights into postbiotics against colorectal cancer

A Self‐Adaptive Pyroptosis Inducer: Optimizing the Catalytic Microenvironment of Nanozymes by Membrane‐Adhered Microbe Enables Potent Cancer Immunotherapy

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