“…Flavonoids can downregulate HIFα and VEGF in different cancer cell lines such as OVCAR-3, A2780, MCF-7 and PC-3 [ 42 , 70 , 95 , 131 , 144 , 145 ]. Many studies have also reported the ability of the flavonoids 3-hydroxy flavone, hesperidin, apigenin, fisetin and many others to reduce tumor size, capillary density and metastasis of different cancers, such as osteosarcoma, melanoma, lung and breast cancers, in xenograft mice [ 26 , 183 , 184 , 185 , 186 , 187 ].…”